| Not Yet Recruiting | Expansion Study of ALT001 in Patients With Multiple System Atrophy NCT07476352 | yilong Wang | EARLY_Phase 1 |
| Not Yet Recruiting | Efficacy and Safety of Butylphthalide in the Treatment of Multiple System Atrophy NCT07518810 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 / Phase 3 |
| Recruiting | An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy NCT07197866 | Teva Branded Pharmaceutical Products R&D LLC | Phase 2 |
| Not Yet Recruiting | hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases NCT06607900 | Xuanwu Hospital, Beijing | Phase 1 |
| Not Yet Recruiting | Efficacy and Safety of Bilateral Cervical Lymphatic-Venous Anastomosis in the Treatment of Multiple System Atr NCT07036939 | Ruijin Hospital | N/A |
| Recruiting | A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA) NCT06868628 | Tiziana Life Sciences LTD | Phase 2 |
| Recruiting | Shanghai Clinical Cohort - Parkinson's Disease (Reserve) NCT07353463 | Ruijin Hospital | — |
| Recruiting | A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy NCT06848231 | Dasher Neuroscience Inc. | Phase 2 |
| Recruiting | Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies NCT06683365 | Craig van Horne, MD, PhD | Phase 1 |
| Completed | [18F] - FD17 PET Imaging of α-synuclein: A Clinical Study in α-synucleinopathy Patients NCT06738862 | Ruijin Hospital | — |
| Active Not Recruiting | A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA) NCT06706622 | H. Lundbeck A/S | Phase 3 |
| Active Not Recruiting | Safety, Tolerability, and Pharmacokinetics of Exidavnemab in Patients With Parkinson's Disease and Patients Wi NCT06671938 | BioArctic AB | Phase 2 |
| Recruiting | The CurePSP Genetics Program NCT06647641 | Massachusetts General Hospital | — |
| Recruiting | A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy NCT06568237 | Teva Branded Pharmaceutical Products R&D LLC | Phase 2 |
| Enrolling By Invitation | Parkinson Atypical Rating of Oculometric Patterns Evaluated Routinely NCT06597071 | NeuraLight | N/A |
| Recruiting | Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746 | Casa di Cura San Raffaele Cassino | — |
| Enrolling By Invitation | Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System NCT06745011 | University of Aarhus | — |
| Recruiting | PET Imaging Evaluation of [11C]SY08 NCT06098612 | Massachusetts General Hospital | EARLY_Phase 1 |
| Recruiting | The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders NCT06174948 | Queen Mary University of London | N/A |
| Recruiting | The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism NCT06162013 | Haukeland University Hospital | Phase 2 |
| Active Not Recruiting | GDNF Gene Therapy for Multiple System Atrophy NCT04680065 | Brain Neurotherapy Bio, Inc. | Phase 1 |
| Recruiting | Medical Decision Making in Multiple System Atrophy NCT06072105 | Medical University Innsbruck | N/A |
| Recruiting | Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Dig NCT07392411 | Beijing Tiantan Hospital | — |
| Recruiting | Therapeutic Education for Multiple System Atrophy (MSA) Patients and Their Caregivers NCT05819957 | University Hospital, Toulouse | N/A |
| Completed | UB-312 in Patients With Synucleinopathies NCT05634876 | NYU Langone Health | Phase 1 |
| Completed | A Biomarker Study of ATH434 in Participants With MSA NCT05864365 | Alterity Therapeutics | Phase 2 |
| Unknown | Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - NCT05807373 | University Hospital, Bordeaux | N/A |
| Completed | Speech Accessibility Project NCT05889260 | University of Illinois at Urbana-Champaign | — |
| Terminated | Trial to Evaluate the Efficacy and Safety of KM-819 Treatment to Slow the Progression of Multiple System Atrop NCT05695378 | Kainos Medicine Inc. | Phase 2 |
| Recruiting | NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian NCT06490926 | Fujian Medical University Union Hospital | — |
| Unknown | Unstructured Eye Tracking as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders NCT05638477 | Conor Fearon | N/A |
| Recruiting | NYSCF Scientific Discovery Biobank NCT06203106 | New York Stem Cell Foundation Research Institute | — |
| Completed | A Study of TAK-341 in Treatment of Multiple System Atrophy NCT05526391 | Takeda | Phase 2 |
| Active Not Recruiting | Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early to Moderate NCT05698017 | Cytora Ltd. | Phase 1 |
| Recruiting | Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes NCT06645626 | University Hospital Southampton NHS Foundation Trust | — |
| Active Not Recruiting | Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy NCT05699460 | AskBio Inc | — |
| Recruiting | North American Prodromal Synucleinopathy Consortium Stage 2 NCT05826457 | Washington University School of Medicine | — |
| Recruiting | Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multipl NCT04165486 | Ionis Pharmaceuticals, Inc. | Phase 1 |
| Completed | Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit NCT04468919 | Oregon Health and Science University | N/A |
| Completed | Study of ATH434 in Participants with Multiple System Atrophy NCT05109091 | Alterity Therapeutics | Phase 2 |
| Active Not Recruiting | Observational Study in Multiple System Atrophy NCT05453058 | H. Lundbeck A/S | — |
| Recruiting | CPAP for the Treatment of Supine Hypertension NCT05489575 | Vanderbilt University Medical Center | N/A |
| Active Not Recruiting | Community Outreach for Palliative Engagement -- Parkinson Disease NCT05222386 | University of Rochester | N/A |
| Completed | Synapse Alterations in MSA Patients NCT06221644 | Xiangya Hospital of Central South University | — |
| Recruiting | Biomarkers in Parkinsonian Syndromes NCT06501469 | Non-profit organization for scientific research in Parkinson's disease and related disorders | — |
| Active Not Recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register S NCT06209515 | Kuopio University Hospital | — |
| Active Not Recruiting | Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mese NCT05167721 | Mayo Clinic | Phase 2 |
| Withdrawn | Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism NCT03446807 | Loma Linda University | Phase 2 |
| Completed | An Observational Study of Parkinson's Disease and Other Synucleinopathies (EASE-PD) NCT05638815 | SciNeuro | — |
| Active Not Recruiting | A Study of Lu AF82422 in Participants With Multiple System Atrophy NCT05104476 | H. Lundbeck A/S | Phase 2 |
| Unknown | Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients NCT05139342 | Kliniken Beelitz GmbH | N/A |
| Unknown | The Effect of Gluten-free Diet on Parkinsonism NCT05238545 | General University Hospital, Prague | N/A |
| Recruiting | Synaptic Loss in Multiple System Atrophy NCT05121012 | University of Exeter | — |
| Completed | Optimization of Morphomer-based Alpha-synuclein PET Tracers NCT05067192 | Skane University Hospital | — |
| Completed | Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy NCT04965922 | University Hospital, Bordeaux | N/A |
| Recruiting | Comprehensive Swallowing Rehabilitation in Patients With MSA NCT04782284 | Seoul National University Hospital | N/A |
| Recruiting | Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms NCT04782830 | Vanderbilt University Medical Center | N/A |
| Completed | Transcranial Alternating Current Stimulation (tACS) in Patients With Ataxia NCT05621200 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Completed | Synuclein-One Study NCT04700722 | CND Life Sciences | — |
| Completed | Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients NCT04616456 | Brigham and Women's Hospital | EARLY_Phase 1 |
| Recruiting | Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients NCT04620382 | Vanderbilt University Medical Center | EARLY_Phase 1 |
| Recruiting | Insulin Resistance in Multiple System Atrophy NCT04250493 | University Hospital, Bordeaux | N/A |
| Unknown | Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy NCT04876326 | Indonesia University | N/A |
| Completed | Exenatide Once-weekly as a Treatment for Multiple System Atrophy NCT04431713 | University College, London | Phase 2 |
| Completed | TRACK-MSA: A Longitudinal Study to Define Outcome Measures in Multiple System Atrophy NCT04450992 | NYU Langone Health | — |
| Completed | Natural History and Disease Progression Biomarkers of Multiple System Atrophy NCT04229173 | University Hospital, Toulouse | N/A |
| Recruiting | [18F]F-DOPA Imaging in Patients With Autonomic Failure NCT04246437 | Daniel Claassen | Phase 1 |
| Terminated | A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synuc NCT04020198 | Stony Brook University | — |
| Active Not Recruiting | Trial of Parkinson's And Zoledronic Acid NCT03924414 | California Pacific Medical Center Research Institute | Phase 4 |
| Completed | Safinamide for Multiple System Atrophy (MSA) NCT03753763 | Zambon SpA | Phase 2 |
| Unknown | Neurodegenerative Diseases Registry NCT04472130 | Vincent Mok | — |
| Unknown | TMS Treatment in Multiple System Atrophy With Fatigue NCT04313530 | Xuanwu Hospital, Beijing | N/A |
| Completed | Study of NBMI Treatment in Patients With Atypical Parkinsons (PSP or MSA) NCT04184063 | EmeraMed | Phase 2 |
| Completed | Study of BHV-3241 in Participants With Multiple System Atrophy NCT03952806 | Biohaven Pharmaceuticals, Inc. | Phase 3 |
| Recruiting | Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms NCT05748028 | Istituti Clinici Scientifici Maugeri SpA | — |
| Terminated | Tllsh2910 for Ataxia and Gut Microbiota Alteration in Patients of Multiple System Atrophy NCT03901638 | National Taiwan University Hospital | Phase 3 |
| Recruiting | Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging NCT03872102 | University of Texas Southwestern Medical Center | — |
| Completed | Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism NCT04518059 | University Hospitals Cleveland Medical Center | — |
| Unknown | Brain Network Activation in Patients With Movement Disorders NCT03269201 | Sheba Medical Center | — |
| Completed | Respiratoy Muscle Strength in Patients With Multiple System Atrophy NCT04287270 | Marmara University | N/A |
| Completed | Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia NCT04153110 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Completed | Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy NCT03593512 | University of Oxford | N/A |
| Active Not Recruiting | Clinical Laboratory Evaluation of Chronic Autonomic Failure NCT03648905 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Terminated | A Futility Trial of Sirolimus in Multiple System Atrophy NCT03589976 | NYU Langone Health | Phase 2 |
| Enrolling By Invitation | North American Prodromal Synucleinopathy Consortium NCT03623672 | Washington University School of Medicine | — |
| Completed | Long-term Follow-up of Phase 1 Clinical Trial of CS10BR05(CS10BR05-MSA101) NCT04495582 | Corestemchemon, Inc. | — |
| Unknown | Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait NCT03721887 | China Medical University Hospital | N/A |
| Completed | In-Home Care for Patients With PSP and Related Disorders NCT03552484 | Rush University Medical Center | N/A |
| Completed | Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-c NCT03403309 | Yonsei University | Phase 2 |
| Completed | Safety and Tolerability of CS10BR05 Inj. in Subjects with Multiple System Atrophy NCT03265444 | Corestemchemon, Inc. | Phase 1 |
| Recruiting | Automated Abdominal Binder for Orthostatic Hypotension NCT03482297 | Vanderbilt University Medical Center | Phase 1 / Phase 2 |
| Recruiting | Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases NCT04706234 | Kliniken Beelitz GmbH | — |
| Recruiting | The Swedish BioFINDER 2 Study NCT03174938 | Skane University Hospital | N/A |
| Completed | More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease NCT03076671 | University of Colorado, Denver | N/A |
| Completed | Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia NCT03120013 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Recruiting | Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension NCT03042988 | Vanderbilt University Medical Center | N/A |
| Completed | Application of Machine Learning Method in Validation of Screening Cognitive Test for Parkinsonisms NCT04858893 | Ospedale Generale Di Zona Moriggia-Pelascini | — |
| Recruiting | Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure NCT02897063 | Vanderbilt University Medical Center | Phase 1 |
| Completed | Biomarkers in Neural Disorders NCT02761707 | University of Pennsylvania | — |
| Active Not Recruiting | Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic NCT02726711 | Vanderbilt University | Phase 1 |
| Recruiting | Gait Analysis in Neurological Disease NCT02994719 | Beth Israel Deaconess Medical Center | — |
| Completed | Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease NCT02640339 | NYU Langone Health | — |
| Completed | Local Heat Stress in Autonomic Failure Patients With Supine Hypertension NCT02417415 | Vanderbilt University | N/A |
| Recruiting | Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failu NCT02429557 | Vanderbilt University Medical Center | Phase 1 |
| Completed | Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA NCT02270489 | Affiris AG | Phase 1 |
| Terminated | Water and Sudafed in Autonomic Failure NCT02149901 | Vanderbilt University | EARLY_Phase 1 |
| Completed | Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy NCT02185677 | University Hospital, Bordeaux | — |
| Completed | Treatment of Parkinson Disease and Multiple System Atrophy Using Intranasal Insulin. NCT02064166 | Peter Novak | Phase 2 |
| Completed | Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA NCT02071459 | University Hospital, Toulouse | Phase 2 / Phase 3 |
| Completed | Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach NCT02008721 | Dr. Johannes Levin | Phase 3 |
| Unknown | Biomarkers in Parkinsonian Syndromes NCT02114242 | University Hospital, Bordeaux | — |
| Completed | Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Ba NCT02132052 | University of Colorado, Denver | — |
| Completed | Evaluation of a Multimodal Neuroimaging Method for Diagnosis in Parkinsonian Syndromes NCT02428816 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Terminated | Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes NCT02445469 | University Hospital, Montpellier | N/A |
| Terminated | Magnetic Resonance Spectroscopy in Autonomic Failure NCT01607268 | Vanderbilt University | — |
| Completed | Evaluation of the Subjective and Objective Painful Threshold in Multiple System Atrophy Pain and Multiple Syst NCT01577992 | University Hospital, Toulouse | N/A |
| Recruiting | Natural History Study of Synucleinopathies NCT01799915 | NYU Langone Health | — |
| Terminated | Study of Rifampicin in Multiple System Atrophy NCT01287221 | Phillip Low | Phase 3 |
| Completed | Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension NCT01316666 | Vanderbilt University Medical Center | — |
| Terminated | Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure NCT01292694 | Vanderbilt University | Phase 1 |
| Completed | Analysis of the Enteric Nervous System Using Colonic Biopsies NCT01353183 | Nantes University Hospital | N/A |
| Recruiting | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford NCT01793168 | Sanford Health | — |
| Withdrawn | The Role of Endothelin in the Supine Hypertension of Autonomic Failure NCT01119417 | Vanderbilt University | Phase 1 |
| Completed | Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) St NCT01136213 | University Hospital, Bordeaux | — |
| Recruiting | Cerebro Spinal Fluid Collection (CSF) NCT04844060 | University Hospital, Strasbourg, France | — |
| Completed | Nebivolol in the Supine Hypertension of Autonomic Failure NCT01044693 | Vanderbilt University | N/A |
| Completed | Clinical Trial to Assess Efficacy, Safety, and Tolerability of Rasagiline Mesylate 1 mg in Patients With Multi NCT00977665 | Teva Branded Pharmaceutical Products R&D, Inc. | Phase 2 |
| Terminated | Lithium in Multiple System Atrophy NCT00997672 | Federico II University | Phase 2 |
| Unknown | Fipamezole in Neurogenic Orthostatic Hypotension NCT00758849 | Juvantia Pharma Ltd | Phase 2 |
| Completed | Autonomic Failure Patients for RNA Blood Sampling NCT00742586 | Vanderbilt University | — |
| Unknown | Botulinum A Toxin in Patients With Parkinson's Disease NCT00822913 | University Of Perugia | Phase 4 |
| Completed | Treatment of Multiple System Atrophy Using Intravenous Immunoglobulins NCT00750867 | University of Massachusetts, Worcester | Phase 2 |
| Completed | Assessment of Ambulatory Polygraphy in the Detection of Sleep Apnea in Multiple System Atrophy (SAMSA) NCT00743561 | University Hospital, Bordeaux | N/A |
| Completed | Trial of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy NCT00911365 | Yonsei University | Phase 2 |
| Completed | Fluoxetine in Multiple System Atrophy Patients NCT01146548 | University Hospital, Toulouse | Phase 2 |
| Completed | Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) NCT00738062 | Chelsea Therapeutics | Phase 3 |
| Terminated | Augmenting Effects of L-DOPS With Carbidopa and Entacapone NCT00547911 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 / Phase 2 |
| Completed | Research of Biomarkers in Parkinson Disease NCT00465790 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Completed | Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease NCT01155492 | Rush University Medical Center | — |
| Unknown | Diagnostic and Prognostic Biomarkers in Parkinson Disease NCT00653783 | The Parkinson Study Group | — |
| Completed | Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes NCT00368199 | Maastricht University Medical Center | — |
| Completed | Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System A NCT00103597 | Royal Brisbane and Women's Hospital | Phase 1 |
| Completed | Cognitive Impairement In Frontotemporal Dementia NCT03452956 | University of Pennsylvania | — |
| Terminated | Neuroprotection and Natural History in Parkinson's Plus Syndromes (NNIPPS) NCT00211224 | King's College London | Phase 3 |
| Completed | Diagnosis and Natural History Study of Patients With Neurological Conditions NCT00001549 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Available | "An Intermediate Size Patient Population Expanded Access Protocol to Evaluate the Safety and Efficacy of Allog NCT07238062 | Hope Biosciences Research Foundation | — |
| Available | Post-Trial Access to ATH434 for Patients With Multiple System Atrophy NCT07531433 | Alterity Therapeutics | — |