Trials / Terminated
TerminatedNCT04020198
A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 8 (actual)
- Sponsor
- Stony Brook University · Academic / Other
- Sex
- All
- Age
- 50 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
This will be an observational study looking at clinical and biomarker characteristics in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Rapid Eye Movement Sleep Behavior Disorder (RBD), Normal Pressure Hydrocephalus and matched controls. Saliva, plasma, serum, urine, and cerebrospinal fluid (CSF) samples will be collected from participants.
Detailed description
This is an observational study looking at clinical and biomarker characteristics in patients with Parkinson's disease (PD), Multiple System Atrophy (MSA), Rapid Eye Movement Sleep Behavior Disorder (RBD), Normal Pressure Hydrocephalus (NPH) and matched controls. Saliva, plasma, serum, urine, and cerebrospinal fluid samples will be collected from participants. Samples will be assessed for levels of misfolded alpha-synuclein aggregates. Clinical characteristics will also be assessed. Misfolded alpha-synuclein aggregates have the potential to serve as an early biomarker for PD and MSA, increasing the ability to diagnose and treat individuals with these diseases earlier. This study examines the effectiveness of using a novel technique for distinguishing between different parkinsonian disorders by measuring small misfolded α-synuclein aggregates in different biofluids.
Conditions
- Parkinson Disease
- Multiple System Atrophy
- Rapid Eye Movement Sleep Behavior Disorder
- Normal Pressure Hydrocephalus
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Biomarker assay | Biomarker assay will be used to quantify levels of misfolded alpha-synuclein aggregates in biofluid samples from patients with Parkinson's disease, multiple system atrophy, rapid eye movement sleep behavior disorder, normal pressure hydrocephalus and controls. |
Timeline
- Start date
- 2020-01-15
- Primary completion
- 2022-10-19
- Completion
- 2022-10-19
- First posted
- 2019-07-15
- Last updated
- 2025-04-06
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04020198. Inclusion in this directory is not an endorsement.