NCT01044693

Nebivolol in the Supine Hypertension of Autonomic Failure

Effect of Nebivolol on Blood Pressure in a Model of Hypertension Sensitive to Potentiation of Nitric Oxide Bioactivity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effect of the antihypertensive drug, nebivolol (Bystolic), compared to metoprolol (Lopressor) and sildenafil (Viagra) on blood pressure in patients with autonomic failure and supine hypertension.

Detailed description

Nebivolol is distinct among beta-blockers by its ability to increase nitric oxide (NO) bioactivity. The contribution of this effect to the pharmacological actions of the drug, however, is difficult to ascertain in normal subjects because of the confounding contribution of the autonomic nervous system. Autonomic failure patients provide a unique model of hypertension devoid of autonomic modulation but sensitive to NO mechanisms. We propose to determine the effect of nebivolol on blood pressure in this patient population. A decrease in blood pressure will imply increased bioactivity of NO. Comparisons will be made with placebo, metoprolol (as a negative control) and sildenafil (as a positive control).

Conditions

• Hypertension
• Pure Autonomic Failure
• Multiple System Atrophy

Interventions

Type	Name	Description
DRUG	Placebo	Placebo capsule
DRUG	Nebivolol 5 mg	Nebivolol 5mg single oral dose
DRUG	metoprolol tartrate 50 mg	metoprolol tartrate 50 mg single oral dose
DRUG	Sildenafil25 mg	Sildenafil 25 mg single oral dose

Timeline

• Start date: 2010-01-01
• Primary completion: 2014-07-01
• Completion: 2014-08-01
• First posted: 2010-01-08
• Last updated: 2015-05-01
• Results posted: 2015-05-01

Locations

1 site across 1 country: United States