NCT03452956

Cognitive Impairement In Frontotemporal Dementia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 997 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.

Detailed description

Comparative and longitudinal studies reveal clinical differences between subgroups of patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA), Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC), and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy and fMRI studies show correlated neural defects in FTD subgroups. The investigators will obtain converging evidence from multiple sources to test hypotheses about the neural basis for cognitive functions such as semantic memory, grammatical processing, and social functioning in these FTD subgroups, while improving clinical care for these patients. Recent studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. The investigators will obtain comparable neuropsychological and biomarker data in order to compare these patient groups.

Conditions

• Frontotemporal Degeneration
• Progressive Supranuclear Palsy
• Multiple System Atrophy

Interventions

Type	Name	Description
OTHER	None-Observation Only	No intervention-this is an observational study

Timeline

• Start date: 2003-07-01
• Primary completion: 2020-07-15
• Completion: 2020-07-15
• First posted: 2018-03-02
• Last updated: 2020-11-12

Locations

1 site across 1 country: United States