| Recruiting | tDCS as Treatment for Motor Function NCT07291687 | Baycrest | N/A |
| Active Not Recruiting | Art Therapy in Progressive Supranuclear Palsy NCT06588673 | Vanderbilt University Medical Center | N/A |
| Recruiting | The CurePSP Genetics Program NCT06647641 | Massachusetts General Hospital | — |
| Active Not Recruiting | A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Sup NCT06355531 | Ferrer Internacional S.A. | Phase 2 |
| Recruiting | The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders NCT06174948 | Queen Mary University of London | N/A |
| Recruiting | The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism NCT06162013 | Haukeland University Hospital | Phase 2 |
| Not Yet Recruiting | Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes NCT06155942 | Assistance Publique Hopitaux De Marseille | N/A |
| Active Not Recruiting | AMX0035 and Progressive Supranuclear Palsy NCT06122662 | Amylyx Pharmaceuticals Inc. | Phase 2 / Phase 3 |
| Completed | Administration of GV1001 for the Treatment of Progressive Supranuclear Palsy Who Completed Study GV1001-PSP-CL NCT06235775 | GemVax & Kael | Phase 2 |
| Recruiting | Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and NCT06529744 | University Health Network, Toronto | — |
| Active Not Recruiting | A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes NCT05956834 | Massachusetts General Hospital | — |
| Completed | GV1001 Subcutaneous(SC) for the Treatment of Progressive Supranuclear Palsy (PSP) NCT05819658 | GemVax & Kael | Phase 2 |
| Completed | Speech Accessibility Project NCT05889260 | University of Illinois at Urbana-Champaign | — |
| Recruiting | NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian NCT06490926 | Fujian Medical University Union Hospital | — |
| Unknown | Unstructured Eye Tracking as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders NCT05638477 | Conor Fearon | N/A |
| Recruiting | NYSCF Scientific Discovery Biobank NCT06203106 | New York Stem Cell Foundation Research Institute | — |
| Recruiting | Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes NCT06645626 | University Hospital Southampton NHS Foundation Trust | — |
| Withdrawn | tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study NCT04883229 | University of California, San Francisco | N/A |
| Active Not Recruiting | Community Outreach for Palliative Engagement -- Parkinson Disease NCT05222386 | University of Rochester | N/A |
| Recruiting | Biomarkers in Parkinsonian Syndromes NCT06501469 | Non-profit organization for scientific research in Parkinson's disease and related disorders | — |
| Completed | Test-retest Study With [18F]PI-2620 in PSP-RS and NDC NCT05187546 | Life Molecular Imaging GmbH | Phase 1 |
| Active Not Recruiting | Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL) NCT05459753 | University of Michigan | N/A |
| Active Not Recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register S NCT06209515 | Kuopio University Hospital | — |
| Unknown | The MOTIVE-PSP Initiative (Progressive Supranuclear Palsy) NCT04691635 | University of Salerno | — |
| Unknown | Study of Comprehensive ANd Multimodal Marker-based Cohort of Progressive Supranuclear Palsy(PSP) NCT05579301 | Seoul National University Hospital | — |
| Completed | A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP) NCT04993768 | Transposon Therapeutics, Inc. | Phase 2 |
| Withdrawn | Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism NCT03446807 | Loma Linda University | Phase 2 |
| Unknown | Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients NCT05139342 | Kliniken Beelitz GmbH | N/A |
| Active Not Recruiting | Automated Imaging Differentiation of Parkinsonism NCT05913687 | University of Florida | — |
| Completed | Optimization of Morphomer-based Alpha-synuclein PET Tracers NCT05067192 | Skane University Hospital | — |
| Terminated | The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy NCT04367116 | Huashan Hospital | N/A |
| Unknown | RT001 in Patients With Progressive Supranuclear Palsy (PSP) PROGRESSIVE SUPRANUCLEAR PALSY NCT04937530 | Biojiva LLC | Phase 2 |
| Completed | Evaluation of [18F]APN-1607 as a PET Biomarker NCT05005819 | Invicro | Phase 1 |
| Active Not Recruiting | Remote Monitoring in Progressive Supranuclear Palsy (PSP) NCT04753320 | Massachusetts General Hospital | — |
| Completed | Personalized Parkinson Project PSP Cohort NCT05501431 | Radboud University Medical Center | — |
| Completed | Mobility in Atypical Parkinsonism: a Trial of Physiotherapy NCT04608604 | Victoria Sidoroff | N/A |
| Completed | Efficacy and Safety of Transcranial dIrect Current stiMulation (tDCS) in Progressive Supranuclear Palsy (PSP) NCT04655079 | University of Salerno | N/A |
| Unknown | Rho Kinase (ROCK) Inhibitor in Tauopathies - 1 NCT04734379 | Woolsey Pharmaceuticals | Phase 2 |
| Completed | Complex Eye Movements in Parkinson's Disease and Related Movement Disorders NCT04925622 | Saccadous, Inc. | — |
| Unknown | Evaluation of Tolfenamic Acid in Individuals With PSP at 12-Weeks NCT04253132 | NeuroTau, Inc. | Phase 1 / Phase 2 |
| Unknown | Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases NCT05260151 | Xuanwu Hospital, Beijing | — |
| Active Not Recruiting | A Study to Test the Safety and Tolerability of Long-term UCB0107 Administration in Study Participants With Pro NCT04658199 | UCB Biopharma SRL | Phase 1 |
| Completed | Evaluation of Imaging Characteristics of [18F]PI-2620 PET in AD and PSP Patients Using High and Low Specific A NCT04715750 | Life Molecular Imaging GmbH | Phase 1 |
| Completed | A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP NCT04008355 | AlzProtect SAS | Phase 2 |
| Unknown | Image Characteristic and Longitudinal Follow up of 18F-PMPBB3 (APN-1607) PET for Progressive Supranuclear Pals NCT04541836 | Chang Gung Memorial Hospital | — |
| Completed | A Study to Test the Safety and Tolerability of UCB0107 in Study Participants With Progressive Supranuclear Pal NCT04185415 | UCB Biopharma SRL | Phase 1 |
| Active Not Recruiting | Trial of Parkinson's And Zoledronic Acid NCT03924414 | California Pacific Medical Center Research Institute | Phase 4 |
| Unknown | Neurodegenerative Diseases Registry NCT04472130 | Vincent Mok | — |
| Completed | Study of NBMI Treatment in Patients With Atypical Parkinsons (PSP or MSA) NCT04184063 | EmeraMed | Phase 2 |
| Recruiting | Quality of Life of the Patient and the Burden of the Caregiver in Progressive Supranuclear Palsy NCT03638505 | Assistance Publique Hopitaux De Marseille | — |
| Completed | Tau Imaging With JNJ067 NCT03926702 | University of California, Berkeley | EARLY_Phase 1 |
| Recruiting | Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging NCT03872102 | University of Texas Southwestern Medical Center | — |
| Completed | Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism NCT04518059 | University Hospitals Cleveland Medical Center | — |
| Unknown | Brain Network Activation in Patients With Movement Disorders NCT03269201 | Sheba Medical Center | — |
| Completed | Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (AP NCT04786158 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | In-Home Care for Patients With PSP and Related Disorders NCT03552484 | Rush University Medical Center | N/A |
| Completed | Phase 1 Test-retest Evaluation of [18F]MNI-958 PET NCT03545789 | Invicro | Phase 1 |
| Completed | 18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls NCT03625128 | Chang Gung Memorial Hospital | EARLY_Phase 1 |
| Completed | tDCS Plus Physical Therapy for Progressive Supranuclear Palsy NCT04237948 | Fondazione Europea di Ricerca Biomedica Ferb Onlus | N/A |
| Recruiting | Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal NCT03225144 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Recruiting | Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases NCT04706234 | Kliniken Beelitz GmbH | — |
| Completed | Cerebellar rTMS Theta Burst for Postural Instability in Progressive Supranuclear Palsy NCT04222218 | Fondazione Europea di Ricerca Biomedica Ferb Onlus | N/A |
| Recruiting | The Swedish BioFINDER 2 Study NCT03174938 | Skane University Hospital | N/A |
| Terminated | A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Subjects With Progressi NCT02985879 | AbbVie | Phase 2 |
| Completed | Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain NCT03058965 | Molecular NeuroImaging | EARLY_Phase 1 |
| Unknown | Oxford Study of Quantification in Parkinsonism NCT04139551 | University of Oxford | — |
| Completed | Evaluation of [18F]MNI-952 as a Potential PET Radioligand for Imaging Tau Protein in the Brain NCT03080051 | Molecular NeuroImaging | EARLY_Phase 1 |
| Completed | Biomarkers in Neural Disorders NCT02761707 | University of Pennsylvania | — |
| Recruiting | Neurologic Stem Cell Treatment Study NCT02795052 | MD Stem Cells | N/A |
| Recruiting | Gait Analysis in Neurological Disease NCT02994719 | Beth Israel Deaconess Medical Center | — |
| Completed | Neuropsychological Evaluation for Early Diagnosis of PSP NCT03478124 | Ospedale Generale Di Zona Moriggia-Pelascini | — |
| Recruiting | A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy NCT02605785 | Mayo Clinic | N/A |
| Completed | Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive NCT02460094 | Biogen | Phase 1 |
| Completed | Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy NCT04096651 | Centre Hospitalier Universitaire de la Guadeloupe | N/A |
| Recruiting | Diagnosing Frontotemporal Lobar Degeneration NCT02964637 | University Health Network, Toronto | — |
| Completed | Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy NCT02494024 | C2N Diagnostics | Phase 1 |
| Completed | Young Plasma Transfusions for Progressive Supranuclear Palsy NCT02460731 | University of California, San Francisco | Phase 1 |
| Completed | A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy NCT02422485 | Adam Boxer | Phase 1 |
| Completed | Study of the Neural Basis of Analogical Reasoning NCT02236832 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers NCT02167594 | Avid Radiopharmaceuticals | Phase 1 |
| Completed | Rehabilitation in Patients With Progressive Supranuclear Palsy NCT02109393 | Ospedale Generale Di Zona Moriggia-Pelascini | N/A |
| Unknown | Biomarkers in Parkinsonian Syndromes NCT02114242 | University Hospital, Bordeaux | — |
| Completed | Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy NCT02734485 | IRCCS San Raffaele Roma | N/A |
| Terminated | Foot Mechanical Stimulation for Treatment of Gait and Gait Related Disorders in Parkinson's Disease and Progre NCT01815281 | IRCCS San Raffaele Roma | N/A |
| Completed | 2-(1-{6-[(2-[F-18]Fluoroethyl) (Methyl)Amino]-2-naphthyl} Ethylidene) Malononitrile-PET for in Vivo Diagnose o NCT02214862 | Fundacion Clinic per a la Recerca Biomédica | EARLY_Phase 1 |
| Unknown | Clinical Trial to Evaluate Bone Marrow Stem Cell Therapy for PSP, a Rare Form of Parkinsonism NCT01824121 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | Phase 1 / Phase 2 |
| Terminated | Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes NCT02445469 | University Hospital, Montpellier | N/A |
| Recruiting | Modifiable Variables in Parkinsonism (MVP) NCT02194816 | Bastyr University | — |
| Completed | Robot Walking Rehabilitation in Parkinson's Disease NCT01668407 | IRCCS San Raffaele Roma | N/A |
| Completed | Postural Instability in Progressive Supranuclear Palsy NCT01563276 | Oregon Health and Science University | — |
| Completed | Evaluating Cerebrospinal Fluid Biomarkers in Alzheimer's, Progressive Supranuclear Palsy Subjects, and Control NCT01348061 | KineMed | — |
| Completed | 4 Repeat Tauopathy Neuroimaging Initiative NCT01804452 | University of California, San Francisco | — |
| Completed | Analysis of the Enteric Nervous System Using Colonic Biopsies NCT01353183 | Nantes University Hospital | N/A |
| Completed | Study to Evaluate the Safety and Efficacy of Davunetide for the Treatment of Progressive Supranuclear Palsy NCT01110720 | Allon Therapeutics | Phase 2 / Phase 3 |
| Completed | Alpha-lipoic Acid/L-acetyl Carnitine for Progressive Supranuclear Palsy NCT01537549 | Weill Medical College of Cornell University | Phase 1 / Phase 2 |
| Terminated | Efficacy, Tolerability and Safety of Azilect in Subjects With Progressive Supranuclear Palsy NCT01187888 | Prof. Dr. Stefan Lorenzl | Phase 3 |
| Completed | Davunetide (AL-108) in Predicted Tauopathies - Pilot Study NCT01056965 | University of California, San Francisco | Phase 1 |
| Completed | Safety, Tolerability, and Efficacy of Two Different Oral Doses of NP031112 Versus Placebo in the Treatment of NCT01049399 | Noscira SA | N/A |
| Completed | Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal Degener NCT01174771 | University of California, Los Angeles | — |
| Completed | A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration NCT00703677 | Westat | Phase 1 / Phase 2 |
| Unknown | Efficacy Study for Treatment of Dementia in Progressive Supranuclear Palsy NCT00522015 | University Hospital Tuebingen | Phase 2 |
| Completed | Research of Biomarkers in Parkinson Disease NCT00465790 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Unknown | Diagnostic and Prognostic Biomarkers in Parkinson Disease NCT00653783 | The Parkinson Study Group | — |
| Completed | Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy (Depakine) NCT00385710 | Nantes University Hospital | Phase 2 |
| Completed | Effects of Coenzyme Q10 in Progressive Supranuclear Palsy (PSP) NCT00382824 | Lahey Clinic | N/A |
| Completed | Risk Factors for Progressive Supranuclear Palsy (PSP) NCT00431301 | University of Louisville | — |
| Completed | Study About Safety and Efficacy of Coenzyme Q10 in Progressive Supranuclear Palsy NCT00328874 | German Parkinson Study Group (GPS) | Phase 2 |
| Completed | A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy. NCT00605930 | University of Louisville | N/A |
| Completed | Effects of Coenzyme Q10 in PSP and CBD NCT00532571 | Lahey Clinic | Phase 2 / Phase 3 |
| Completed | Cognitive Impairement In Frontotemporal Dementia NCT03452956 | University of Pennsylvania | — |
| Completed | Continuously Infused Recombinant-Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (GDNF) to Treat P NCT00005903 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 |
| Terminated | Neuroprotection and Natural History in Parkinson's Plus Syndromes (NNIPPS) NCT00211224 | King's College London | Phase 3 |