NCT00431301

Risk Factors for Progressive Supranuclear Palsy (PSP)

Genetic and Environmental Risk Factors for PSP

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 942 (actual)
• Sponsor: University of Louisville · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement disorder. This study will determine the role of specific genetic, occupational and environmental components in the development of PSP by evaluating patients with this disorder and age and gender matched controls.

Detailed description

This proposal will determine: (1) if there is an association between PSP and specific genes of interest; (2) if there is an association between PSP and occupational and/or environmental chemical exposures functionally or structurally similar to known parkinsonian toxicants; and (3) if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP. To disentangle the complex etiology of PSP, this case-control multicenter study involves 500 PSP cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic confirmation. Understanding the etiology of PSP may also help explain the causes of other related diseases such as Alzheimer's disease. This multidisciplinary team of movement disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist and toxicologist is well suited to unravel the etiology of PSP.

Conditions

• Progressive Supranuclear Palsy

Timeline

• Start date: 2006-08-01
• Primary completion: 2013-02-01
• Completion: 2013-06-01
• First posted: 2007-02-05
• Last updated: 2017-04-10

Locations

10 sites across 2 countries: United States, Canada