NCT03721887

Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: China Medical University Hospital · Academic / Other
• Sex: All
• Age: 30 Years – 85 Years
• Healthy volunteers: Accepted

Summary

In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a double blind randomized design. Six assessments with different combinations of clinical scaling, gait analysis, electrophysiological investigation and fMRI examinations before and after tDCS will be conducted. The treatment and placebo groups will be crossed over after one-month washout. The investigators will investigate whether the possible tDCS beneficial effect will be different or similar in patients with different electric sources. In addition, how long the possible beneficial effect of tDCS can be consolidated after the 5-day course of stimulation is also crucial. The investigators aim to peep the myth of FOG in PD and MSA by the multi-modality approach and hope the study will benefit the long suffering patients.

Conditions

• Parkinson's Disease
• Multiple System Atrophy

Interventions

Type	Name	Description
DEVICE	Transcranial direct current stimulation	A consecutive 5-days course of tDCS will be delivered. In treatment group, true stimulation will be administrated and sham stimulation will be delivered in control group.

Timeline

• Start date: 2018-08-01
• Primary completion: 2020-07-31
• Completion: 2021-07-31
• First posted: 2018-10-26
• Last updated: 2018-10-26

Locations

1 site across 1 country: Taiwan