| Not Yet Recruiting | ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral NCT06167213 | Edwards Lifesciences | N/A |
| Not Yet Recruiting | EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States) NCT07517588 | Polares Medical SA | N/A |
| Not Yet Recruiting | The EMBRACE Registry: European Post-Market Registry for Catheter Based Mitral Valve Replacement NCT07409285 | HighLife SAS | — |
| Not Yet Recruiting | Study for the Identification of Subclinical Atrial Fibrillation In Patients With Significant Primary Mitral Re NCT07377799 | Rigshospitalet, Denmark | — |
| Not Yet Recruiting | Combined Mitral and Tricuspid Versus Isolated Mitral Transcatheter Edge-to-Edge Repair for Mitral Regurgitatio NCT07349888 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Recruiting | A Clinical Study Evaluating the Replacement of the Native Mitral Valve Using the ReValve System NCT07450911 | ReValve Solutions Inc. | Phase 1 |
| Not Yet Recruiting | A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR. NCT07086534 | Sierra Valve LLC | N/A |
| Active Not Recruiting | The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgu NCT07366723 | Centro Cardiologico Monzino | N/A |
| Not Yet Recruiting | Reduction of Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) NCT07130994 | InnovHeart | N/A |
| Not Yet Recruiting | Additive Prognostic Value of PALS Compared to Bernard's Staging in Patients Undergoing MV Surgery NCT07151495 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Abbott Cephea Mitral Valve Disease Registry NCT07069673 | Abbott Medical Devices | — |
| Recruiting | STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Ind NCT07007143 | Chinese Academy of Medical Sciences, Fuwai Hospital | Phase 4 |
| Recruiting | Outcome Registry and Assessment of New Edge-to-Edge Repair NCT07108907 | Abby Geerlings | — |
| Recruiting | Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve NCT07097740 | Mitrassist Lifesciences Limited Co., Ltd. | N/A |
| Recruiting | Cephea South America Feasibility Study NCT07244939 | Abbott Medical Devices | N/A |
| Recruiting | STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indica NCT06901466 | Chinese Academy of Medical Sciences, Fuwai Hospital | Phase 4 |
| Recruiting | Sutra Hemi-valve First-in-Human Study NCT06552689 | Sutra Medical, Inc. | N/A |
| Recruiting | Structural Heart Surgery Assist System for Transcatheter Mitral Valve Edge-to-Edge Repair (TEER). NCT07055919 | Xiamen Cardiovascular Hospital, Xiamen University | N/A |
| Recruiting | Mitral Valve Annulus Assessment, Multimodality Imaging NCT06797687 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | CAP-TEER: CerebrAl Protection During Transcatheter Edge-to-edge Repair NCT06814210 | Xiao-dong Zhuang | N/A |
| Recruiting | Capstan Medical TMVR Study: FIH NCT06600191 | Capstan Medical | N/A |
| Not Yet Recruiting | Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients Wi NCT06667128 | IRCCS Ospedale San Raffaele | N/A |
| Recruiting | A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Pre NCT06836011 | Medical University of Vienna | — |
| Recruiting | The Multi-center Study of Comprehensive Atrial Fibrillation Regurgitation and Recurrent Events Evaluation NCT07085650 | First Hospital of China Medical University | — |
| Recruiting | The CardioClip Study NCT06241430 | Columbia University | N/A |
| Recruiting | Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease NCT06780241 | The Cleveland Clinic | — |
| Not Yet Recruiting | Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery NCT06664320 | Konkuk University Medical Center | N/A |
| Not Yet Recruiting | LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY NCT06547788 | Ottawa Heart Institute Research Corporation | N/A |
| Recruiting | AltaValve Pivotal Trial NCT06465745 | 4C Medical Technologies, Inc. | N/A |
| Completed | Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform NCT06099665 | Tempus AI | N/A |
| Recruiting | Mixed Reality in MitraClip Implantation: Preliminary Case Series NCT06539416 | Nemocnice AGEL Trinec-Podlesi a.s. | — |
| Not Yet Recruiting | Concomitant Tricuspid Repair in Patients With Left Heart Surgery NCT05595187 | Nanjing Medical University | N/A |
| Recruiting | MitraClip in Patients With Heart Failure NCT06633159 | The League of Clinical Research, Russia | — |
| Recruiting | Feasibility Study of the Tioga TMVR System NCT06038838 | Tioga Cardiovascular, Inc. | N/A |
| Recruiting | Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer Population NCT06634121 | LMU Klinikum | N/A |
| Recruiting | Comparison of Transcatheter Edge-to-edge Repair Using Echo Only with Echo Combined with X Ray for Mitral Regur NCT06684171 | Pan Xiangbin | N/A |
| Completed | Cryoablation of Intercostal Nerves for Pain Management in Early Postoperative Period in Patients With Minimall NCT06443931 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Not Yet Recruiting | Enhanced External Counter Pulsation on Afterload Mismatch Rate in Post-TEER (PAMPER) NCT06227286 | Sun Yat-sen University | N/A |
| Recruiting | Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery NCT06255457 | Karolinska Institutet | — |
| Recruiting | TEER for Severe DMR of Low to Intermediate Surgery Risk NCT06162780 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Not Yet Recruiting | Edge-to-edge Mitral Valve Repair in ATTR-CM NCT06075823 | Medical University of Vienna | N/A |
| Unknown | Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Fai NCT06278727 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Not Yet Recruiting | Munich Transcatheter Mitral Valve Safety and Effectiveness NCT05871983 | P+F Products + Features GmbH | N/A |
| Unknown | The China Mviv Registry NCT05925335 | Xiamen Cardiovascular Hospital, Xiamen University | N/A |
| Completed | Early Discharge After Mitral and Tricuspid Edge-to-edge Repair: an Assessment of Feasibility and Safety NCT06343363 | Oxford University Hospitals NHS Trust | — |
| Unknown | Clinical Investigation for the Foldax Tria Mitral Valve- India NCT06191718 | Foldax, Inc | N/A |
| Unknown | Evaluation of Mitral Valve Insufficiency Under General Anesthesia NCT05736289 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Tr NCT05496998 | Medtronic Cardiovascular | N/A |
| Unknown | Mitral Splay Sign, Its Mechanism and Association With Severity of Regurgitation NCT06152315 | ITMO University | — |
| Unknown | Multimodality Imaging Assessment of the Severity of Mitral Regurgitation NCT06266858 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | N/A |
| Recruiting | Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate- NCT05655897 | Peijia Medical Technology (Suzhou) Co., Ltd. | N/A |
| Unknown | European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation NCT05425628 | NeoChord | N/A |
| Recruiting | Safety and Efficacy of the HighLife Transcatherter Mitral Valve Replacement System in Patients With Moderate-s NCT05610566 | Peijia Medical Technology (Suzhou) Co., Ltd. | N/A |
| Unknown | The Multicenter Clinical Trial of a Novel TEER Decive (V-CLASP Trial) NCT05391802 | Shanghai Zhongshan Hospital | N/A |
| Unknown | Haemodynamics of Mitral Regurgitation Reduction NCT05403840 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock NCT05298124 | Ottawa Heart Institute Research Corporation | N/A |
| Completed | Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac S NCT05475561 | Alexandria University | Phase 2 |
| Recruiting | Cephea Early Feasibility Study NCT05061004 | Abbott Medical Devices | N/A |
| Enrolling By Invitation | Optimal PeriproCeduraL AnticOagulation in Structural Transseptal Interventions NCT05305612 | National Institute of Cardiology, Warsaw, Poland | Phase 4 |
| Unknown | Outcomes of Patients tReated wIth Mitral Transcatheter Edge-to-edge Repair for Primary Mitral Regurgitation Re NCT05332782 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | The Role of Left Atrial Fibrosis in Mitral Valve Repair Surgery (ALIVE Trial) NCT05345730 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Unknown | Structural Mitral Valve Project NCT05678868 | Queen's University | — |
| Completed | MitraClip China PMS NCT04259411 | Abbott Medical Devices | N/A |
| Completed | Virtual Reality Reduces Pre-Procedural Anxiety in TEER Patients, But Timing Seems Crucial NCT07263659 | Abby Geerlings | N/A |
| Recruiting | Valveclip® Transcatheter Mitral Valve Repair Study NCT05021614 | Shanghai NewMed Medical Co., Ltd. | N/A |
| Unknown | Left Chamber Function in Mitral Regurgitation and Predicting Outcome After Replacement and Targeting for Early NCT03870516 | Assiut University | N/A |
| Enrolling By Invitation | A Study to Evaluate a Computerized Stethoscope Called ©Voqx to Diagnose Heart Disease NCT04960280 | Mayo Clinic | N/A |
| Withdrawn | Carillon Mitral Contour System for Treatment of Exercise Induced Functional Mitral Regurgitation NCT05040451 | Cardiac Dimensions Pty Ltd | — |
| Unknown | Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair NCT05034471 | Medical University of Vienna | N/A |
| Unknown | Change in LVEF Following Transcatheter Mitral Edge-To-Edge Repair NCT05311163 | Rabin Medical Center | — |
| Recruiting | EFS of the CardioMech MVRS NCT04820764 | CardioMech AS | N/A |
| Completed | Edge-To-Edge Technique Used as a Bailout in Case of Sub-Optimal Mitral Repair: Very Long-Term Results NCT05733988 | Michele De Bonis | — |
| Recruiting | HighFLO Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLAR NCT04888247 | HighLife SAS | N/A |
| Withdrawn | Acquisition of Objective Data During Transapical Neochordae Implantation NCT04709042 | Hospices Civils de Lyon | N/A |
| Recruiting | Mitral Regurgitation Treatment in Advanced Heart Failure NCT05292716 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Recruiting | Tendyne European Experience Registry NCT04898335 | LMU Klinikum | — |
| Unknown | Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery NCT04770961 | University of California, San Francisco | N/A |
| Recruiting | SQ-Kyrin TMVr FIM Study NCT05040074 | Shanghai Shenqi Medical Technology Co., Ltd | N/A |
| Completed | LOng-Term Fate of Moderate Aortic Regurgitation Left Untreated at the Time of Mitral Valve Surgery NCT05774795 | Michele De Bonis | — |
| Unknown | Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions NCT05374733 | Erasmus Medical Center | N/A |
| Active Not Recruiting | Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip NCT04729933 | samir kapadia | N/A |
| Recruiting | The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves). NCT04408430 | Mayra Guerrero | N/A |
| Recruiting | Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study NCT04761120 | Abbott Medical Devices | — |
| Recruiting | In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation NCT06675448 | Inova Health Care Services | — |
| Recruiting | Evaluating Infrasonic Hemodynography NCT04636892 | Scripps Health | N/A |
| Active Not Recruiting | Beating Heart Mitral Valve Repair With the HARPOON™ System NCT04375332 | Edwards Lifesciences | N/A |
| Recruiting | Use of Phenylephrine for Assessment of Mitral Regurgitation Severity NCT04500899 | Montefiore Medical Center | Phase 1 / Phase 2 |
| Completed | Is Mitral Annuloplasty an Effective Treatment for Severe Atrial Functional MR? NCT05836376 | Michele De Bonis | — |
| Recruiting | The ENCIRCLE Trial NCT04153292 | Edwards Lifesciences | N/A |
| Recruiting | CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry NCT04688190 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | Transcatheter Mitral Valvuloplasty Pilot Study NCT04351984 | Duk-Woo Park, MD | — |
| Terminated | Treatment of Mitral Regurgitation Using a Minimally Invasive Approach With the HARPOON Device. NCT04382612 | Edwards Lifesciences | N/A |
| Completed | Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair NCT04200378 | Mayo Clinic | — |
| Unknown | SATURN Transcatheter Mitral Valve Replacement for Functional Mitral Regurgitation NCT04464876 | InnovHeart | N/A |
| Unknown | Dragonfly-M Early Feasibility Study NCT04528576 | Hangzhou Valgen Medtech Co., Ltd | N/A |
| Completed | Prospective Analysis of the Feasibility of the PASCAL Spacer Technology for Transcatheter Mitral Valve Repair NCT04473092 | University Hospital, Essen | — |
| Recruiting | An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System NCT04029337 | HighLife SAS | N/A |
| Completed | Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes NCT04400513 | Eko Devices, Inc. | — |
| Unknown | 3D Echocardiography and Cardiovascular Prognosis in Mitral Regurgitation NCT04442828 | Haukeland University Hospital | — |
| Unknown | Evaluation of Robotic-assisted Mitral Surgery With the daVinci X Surgical System NCT04415138 | Cliniche Humanitas Gavazzeni | — |
| Unknown | Neochordae Technique in Mitral Valve Repair NCT04299334 | National Heart Institute, Egypt | Phase 1 |
| Recruiting | Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System NCT04190602 | NeoChord | — |
| Active Not Recruiting | MitraClip EXPAND G4 Study NCT04177394 | Abbott Medical Devices | — |
| Terminated | Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valv NCT04245956 | University Hospital, Geneva | N/A |
| Terminated | Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation NCT04098328 | Polares Medical SA | — |
| Unknown | AltaValve Early Feasibility Study Protocol NCT03997305 | 4C Medical Technologies, Inc. | N/A |
| Unknown | Treatment of Concomitant Mitral Regurgitation by Mitral Valve Clipping in Patients With Successful Transcathet NCT04009434 | Technische Universität Dresden | N/A |
| Completed | 5-Year Follow-Up Safety and Performance Evaluation of the Medtentia Annuloplasty Ring in Adults NCT04161079 | Medtentia International Ltd Oy | — |
| Completed | Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causi NCT05836532 | Michele De Bonis | — |
| Completed | Immediate Suboptimal Result of Mitral Valve Repair: Late Implications in a Matched Cohort Study NCT05836480 | Michele De Bonis | — |
| Completed | Mitral Regurgitation in Hypertrophic Obstructive Cardiomyopathy: Fix it in a Simple, Effective and Durable Way NCT05850026 | Michele De Bonis | — |
| Completed | Pleth Variability Index (PVI) as a Measure of Volume Status During Transcatheter Mitral Valve Repair NCT03993938 | Henry Ford Health System | N/A |
| Unknown | Transcatheter Treatment for Combined Aortic and Mitral Valve Disease. The Aortic+Mitral TRAnsCatheter (AMTRAC) NCT04031274 | Rabin Medical Center | — |
| Withdrawn | Feasibility Study of Patients With Severe MR Treated With the Cardiovalve TMVR System NCT03714412 | Cardiovalve Ltd. | N/A |
| Recruiting | MiCLASP Post Market Clinical Follow-Up (PMCF) Study NCT04430075 | Edwards Lifesciences | — |
| Unknown | MitralStitch Mitral Valve Repair System for Mitral Regurgitation NCT04061837 | Xijing Hospital | N/A |
| Unknown | The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Cap NCT04051411 | Atlantic Health System | — |
| Unknown | Safety and Performance Study of the MitralStitch Repair System. NCT04080362 | Hangzhou Valgen Medtech Co., Ltd | N/A |
| Completed | PASCAL vs. MitralClip for Mitral Valve Transchatheter Edge-to-Edge Repair NCT05865938 | Heinrich-Heine University, Duesseldorf | — |
| Recruiting | Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe NCT04029363 | HighLife SAS | N/A |
| Terminated | Cardiovalve Transfemoral Mitral Valve System NCT03813524 | Boston Biomedical Associates | N/A |
| Completed | Percutaneous Mitral Valve Intervention: Predicting Improvements in Left Ventricular Performance NCT04156295 | Guy's and St Thomas' NHS Foundation Trust | — |
| Unknown | MitraClip for the Treatment of Moderate Functional Mitral Regurgitation: EVOLVE-MR NCT03705312 | Montreal Heart Institute | N/A |
| Completed | A Pan-Canadian, Retrospective Evaluation of MitraClip Safety and Efficacy NCT03592043 | Population Health Research Institute | — |
| Active Not Recruiting | Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial NCT03706833 | Edwards Lifesciences | N/A |
| Completed | Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification NCT03539458 | Abbott Medical Devices | N/A |
| Completed | Cephea Transseptal Mitral Valve System FIH NCT03988946 | Cephea Valve Technologies | N/A |
| Unknown | Patient Specific Mitral Valve Modeling for Surgical Planning and Training NCT03609931 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Active Not Recruiting | Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System NCT03433274 | Abbott Medical Devices | N/A |
| Unknown | Edwards Cardioband European Post-Market Study, MiBAND NCT03600688 | Edwards Lifesciences | — |
| Unknown | Transcatheter Mitral Valve Repair as Bridge Therapy to Heart Transplantation NCT04293575 | Scientific Institute San Raffaele | — |
| Unknown | Primary Mitral Regurgitation Repair NCT04067635 | Eric Y. Yang, MD PhD | — |
| Completed | Strain Imaging in Patients With Functional Mitral Regurgitation, Treated With MitraClip NCT04218578 | University of Athens | — |
| Completed | The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices NCT03502811 | Abbott Medical Devices | — |
| Active Not Recruiting | AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System NCT03339115 | Cardiovalve Ltd. | N/A |
| Completed | MitraClip NT System Post-marketing Surveillance Study - Japan NCT03500692 | Abbott Medical Devices | — |
| Unknown | ChordArt System for Mitral Regurgitation NCT03581656 | CoreMedic GmbH | N/A |
| Active Not Recruiting | Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regur NCT03271762 | Nantes University Hospital | N/A |
| Completed | Phono- and Electrocardiogram Assisted Detection of Valvular Disease NCT03458806 | University of California, San Francisco | — |
| Active Not Recruiting | Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation NCT03292497 | Ottawa Heart Institute Research Corporation | N/A |
| Unknown | Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery NCT02633423 | Ospedale San Raffaele | N/A |
| Unknown | Epicardial Mitral Repair Trial - ENRAPT-MR NCT03864848 | Mitre Medical Corp. | N/A |
| Completed | Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Funct NCT07227675 | Abbott Medical Devices | N/A |
| Enrolling By Invitation | Cardiovalve Transfemoral System - FIM Study NCT03958773 | Cardiovalve Ltd. | N/A |
| Active Not Recruiting | SAPIEN M3 EFS: Early Feasibility Study of the Edwards SAPIEN M3 System for the Treatment of Mitral Regurgitati NCT03230747 | Edwards Lifesciences | N/A |
| Unknown | Caisson Transcatheter Mitral Valve Replacement (TMVR) NCT03661398 | Caisson Interventional LLC | N/A |
| Enrolling By Invitation | The CINCH-FMR Post-Market Registry: Percutaneous Repair in Functional Mitral Regurgitation NCT05677568 | Cardiac Dimensions, Inc. | — |
| Terminated | Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE) NCT03016975 | Edwards Lifesciences | N/A |
| Completed | Silent sTROke duriNG MitraClip Implantation NCT03104556 | Charite University, Berlin, Germany | — |
| Completed | The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study NCT03155373 | Imperial College London | — |
| Unknown | The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Sig NCT04217135 | Kaohsiung Veterans General Hospital. | Phase 4 |
| Unknown | Effect of MitraClip on Acute and Chronic Reverse Cardiac Remodeling Assessed by CMR: The MITRA-REVERSE Study NCT02924363 | Dipan Shah | — |
| Completed | MitraClip in Acute Mitral Regurgitation NCT03107455 | Fundación Investigación Sanitaria en León | — |
| Terminated | A Feasibility Registry of Actigraphy Monitoring in Degenerative Mitral Regurgitation Subjects Receiving the Mi NCT02858245 | Abbott Medical Devices | — |
| Recruiting | Dutch-AMR: Early Mitral Valve Repair Versus Watchful Waiting in Asymptomatic Patients With Severe Mitral Regur NCT03975998 | UMC Utrecht | — |
| Terminated | REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System NCT02703311 | Edwards Lifesciences | N/A |
| Completed | Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients NCT02728739 | Metanoic Health Ltd. | N/A |
| Unknown | MitraClip® After Surgical Mitral Valve Repair NCT02853955 | LMU Klinikum | — |
| Completed | Degenerative Mitral Regurgitation in Intermediate Risk Patients NCT02604745 | Northwestern University | — |
| Unknown | Remote Monitoring of Patients With Functional Mitral Regurgitation Undergoing Mitraclip Transcatheter Repair NCT02698150 | Azienda Ospedaliero, Ferrarotto Alessi | — |
| Unknown | The Papillary Muscle Approximation Provide Stability of Mitral Valve Repair for Ischemic Mitral Regurgitation NCT03038204 | The Federal Centre of Cardiovascular Surgery, Russia | — |
| Unknown | GIse Registry Of Transcatheter Treatment of Mitral Valve regurgitaTiOn (GIOTTO) NCT03521921 | IRCCS Policlinico S. Donato | — |
| Completed | Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery NCT02502448 | Konkuk University Medical Center | N/A |
| Completed | AMENDTM Mitral Valve Repair System, Annuloplasty Ring Applied in a Transcatheter Method NCT02602613 | Valcare Medical Ltd. | N/A |
| Unknown | (MitraClip in Non-Responders to Cardiac Resynchronization Therapy) NCT02592889 | Hospital Clinic of Barcelona | Phase 4 |
| Completed | The Role of Myocardial Fibrosis in Degenerative Mitral Regurgitation NCT02355418 | University Hospital Birmingham NHS Foundation Trust | — |
| Terminated | Observational Study of the Heart Repair Technologies Mitral Bridge in Treating Mitral Valve Regurgitation NCT03511716 | Heart Repair Technologies, Inc. | — |
| Recruiting | MitraClip® Registry NCT02033811 | Klinik für Kardiologie, Pneumologie und Angiologie | — |
| Completed | Atrial Fibrillation Risk After Miniinvasive Mitral Valve Repair NCT06707506 | Nemocnice AGEL Trinec-Podlesi a.s. | — |
| Unknown | Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Funct NCT01626079 | Abbott Medical Devices | N/A |
| Completed | MITRAFIT- Cardinal Adjustable Mitral Repair Follow-up International Postmarketing Surveillance (PMS) NCT01617720 | Edwards Lifesciences | — |
| Completed | Deep Sedation Instead of General Anaesthesia in Percutaneous Mitral Valve Repair Using the MitraClip® System NCT02023762 | Heinrich-Heine University, Duesseldorf | — |
| Completed | Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery NCT02831270 | Konkuk University Medical Center | — |
| Terminated | MitraClip System in Australia and New Zealand NCT01301625 | Abbott Medical Devices | — |
| Completed | Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease NCT03278574 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Completed | Cardioband With Transfemoral Delivery System NCT01841554 | Edwards Lifesciences | N/A |
| Unknown | Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery NCT01431222 | Deutsches Herzzentrum Muenchen | Phase 4 |
| Terminated | Study on Safety and Performance of Medtentia Mitral Valve Repair System in Surgical Repair of Mitral Regurgita NCT01678144 | Medtentia International Ltd Oy | N/A |
| Recruiting | Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) NCT02996552 | Ospedale San Raffaele | N/A |
| Unknown | Mitral Insufficiency Reduction With Biventricular Pacing NCT01242397 | Trinity Medical Center, Illinois | Phase 1 |
| Completed | Identifying an Ideal Cardiopulmonary Exercise Test Parameter NCT01162083 | Imperial College London | — |
| Unknown | Comparison Study of Echocardiography and Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral NCT04038879 | Atlantic Health System | — |
| Withdrawn | Medical Versus Surgical Management of Moderate Mitral Regurgitation Following Percutaneous Coronary Interventi NCT01156441 | Southern Illinois University | Phase 1 / Phase 2 |
| Completed | The Effect of Percutaneous Superior Venae Cava Cannulation Clamping on Cerebral Near Infrared Spectroscopy in NCT01166841 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Suspended | Safety and Efficacy Study of the PTMA Device to Reduce Mitral Valve Regurgitation in Patients With Heart Failu NCT00815386 | Viacor | Phase 2 / Phase 3 |
| Completed | Real World Expanded Multicenter Study of the MitraClip® System (REALISM) NCT01931956 | Abbott Medical Devices | N/A |
| Unknown | Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR) NCT00970034 | Ankara University | — |
| Completed | A Study of Percutaneous Repair of Functional Mitral Regurgitation Using the Ancora Heart, Inc. AccuCinch® Vent NCT00800046 | Ancora Heart, Inc. | N/A |
| Suspended | Study of Safety and Efficacy of the Percutaneous Reduction of Mitral Valve Regurgitation in Heart Failure Pati NCT00787293 | Viacor | Phase 2 |
| Completed | Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000 NCT00665301 | Woolsthorpe Technologies, LLC | — |
| Terminated | Using Beta Blockers to Treat Mitral Regurgitation NCT00700947 | Wake Forest University Health Sciences | Phase 1 |
| Unknown | Speckle Tracking Imaging and Realtime 3 Dimensional Echocardiograhy to Study LV Function and Remodeling After NCT00745680 | National Taiwan University Hospital | — |
| Active Not Recruiting | Genomic Investigation of Cardiovascular Diseases NCT00722748 | Scripps Translational Science Institute | — |
| Completed | Repair of Ischemic Mitral Regurgitation: Comparison Between Flexible and Rigid Annuloplasty Rings NCT00491452 | Shaare Zedek Medical Center | — |
| Completed | EVEREST II Pivotal Study High Risk Registry (HRR) NCT01940120 | Abbott Medical Devices | N/A |
| Completed | Aachen Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral Regurgi NCT00572091 | Viacor | Phase 1 / Phase 2 |
| Completed | Randomised Ischaemic Mitral Evaluation (RIME) Trial NCT00413998 | Imperial College London | EARLY_Phase 1 |
| Completed | Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral Regurgitation NCT00568230 | Viacor | Phase 1 |
| Completed | Prognosis in Asymptomatic Mitral Regurgitation (PAMIR) Study NCT00509080 | University Hospital, Basel, Switzerland | — |
| Completed | Montreal Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device NCT00571610 | Viacor | Phase 1 |
| Completed | Pivotal Study of a Percutaneous Mitral Valve Repair System NCT00209274 | Abbott Medical Devices | N/A |
| Completed | Molecular Mechanisms of Mitral Regurgitation-Aim 2 NCT01052532 | University of Alabama at Birmingham | — |
| Completed | Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) NCT01052428 | University of Alabama at Birmingham | Phase 2 / Phase 3 |
| Completed | Feasibility Study of a Percutaneous Mitral Valve Repair System. NCT00209339 | Abbott Medical Devices | Phase 1 / Phase 2 |
| Completed | Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitr NCT01621971 | Konkuk University Medical Center | Phase 3 |
| Completed | Angiotensin-II Blockade in Mitral Regurgitation NCT00587470 | Mayo Clinic | Phase 4 |
| Completed | Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation NCT01703806 | Asan Medical Center | — |