NCT05836376

Is Mitral Annuloplasty an Effective Treatment for Severe Atrial Functional MR?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 55 (actual)
• Sponsor: Michele De Bonis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Atrial functional mitral regurgitation (MR) is caused by annular dilatation and flattering associated with altered atria/annulus dynamics in patients with severely dilated left atrium and normal leaflets anatomy. Inadequate leaflets adaption is considered a mechanistic culprit as well. Prevalence of at least moderate atrial functional MR varies between 4.7% and 7% in patients with permanent and long standing persistent atrial fibrillation (AF) and is even higher in patients with Heart Failure with preserved Ejection Fraction (HFpEF). Unlike secondary MR in the setting of left ventricular disease, results of surgical treatment of severe atrial functional MR has remained largely unspoken. The aim of this study is to analyze short and mid-term results of isolated annuloplasty in patients with severe, symptomatic atrial functional MR, in comparission to a matched cohort of patients with secondary MR.

Conditions

• Mitral Regurgitation

Interventions

Type	Name	Description
PROCEDURE	Mitral valve annuloplasty	implantation of a prosthetic ring to treat mitral valve regurgitation

Timeline

• Start date: 2020-11-30
• Primary completion: 2020-12-02
• Completion: 2020-12-02
• First posted: 2023-05-01
• Last updated: 2023-05-01

Locations

1 site across 1 country: Italy