NCT06266858

Multimodality Imaging Assessment of the Severity of Mitral Regurgitation

A Single-Center, Open-Label Study to Assess the Severity of Mitral Regurgitation With Multimodality Imaging

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To investigate to assess the severity of mitral regurgitation by multimodality imaging.

Detailed description

In the single-center and open-label study, the researcher will compare the changes of ultrasonic cardiography (UCG) parameters when patients in fasting, anaesthesia and rehydration firstly. The aims are to clarify the effect of fasting and anaesthesia on the assessment of mitral regurgitation (MR) severity and the corrective effect of intravenous rehydration. The researcher then will investigate the correlation and consistency of multimodality imaging in assessing the severity of mitral regurgitation. The aim is to acquire more accurate, objective and reproducible parameters, to provide new solution for the precise assessment of MR severity and to guide the selection of clinical treatment and timing.

Conditions

• Mitral Regurgitation

Interventions

Type	Name	Description
OTHER	rehydration	The fasting patients in anaesthetised receive saline rehydration to maintain central venous pressure of 6-8 cmH2O when undergoing UCG.
DIAGNOSTIC_TEST	UCG	UCG is the most common imaging modality to assess the mitral regurgitation in clinical and also is the primary modality recommended by guidelines. At the beginning of the study, the fasting patients receive UCG in the different situation such as pre-anaesthetic, post-anaesthetic and post-rehydration.
DIAGNOSTIC_TEST	CMR	CMR may be more accurate than UCG in assessing MR severity. In another time, the patients receive CMR.
OTHER	fasting	At the beginning of the study, the patients need to fast when receive UCG.

Timeline

• Start date: 2022-12-01
• Primary completion: 2024-06-30
• Completion: 2024-06-30
• First posted: 2024-02-20
• Last updated: 2024-02-20

Locations

1 site across 1 country: China