Trials / Recruiting
RecruitingNCT06836011
A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.
Definition and Prognosis of Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy - a Prospective International Multicenter Study
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 600 (estimated)
- Sponsor
- Medical University of Vienna · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The objective of this prospective registry study is to comprehensively characterize the prevalence, (semi-) quantitative parameters, and associated clinical outcomes of mitral (MR) and tricuspid regurgitation (TR) in patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM). The study further aims to develop and implement new grading standards for the quantitative assessment of regurgitation severity, tailored to the distinct hemodynamic profile of ATTR-CM. This approach seeks to address the limitations of current regurgitation severity classifications, which do not adequately reflect the unique pathophysiology of a restrictive phenotype as seen in ATTR-CM.
Conditions
- ATTR Amyloidosis With Cardiomyopathy
- ATTR-CM
- ATTR Amyloidosis Wild Type
- Mitral Regurgitation
- Tricuspid Regurgitation
Timeline
- Start date
- 2025-01-01
- Primary completion
- 2025-12-31
- Completion
- 2026-12-31
- First posted
- 2025-02-19
- Last updated
- 2025-02-19
Locations
8 sites across 4 countries: Austria, Germany, Italy, Netherlands
Source: ClinicalTrials.gov record NCT06836011. Inclusion in this directory is not an endorsement.