| Enrolling By Invitation | Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study NCT06954792 | Columbia University | — |
| Not Yet Recruiting | TRicuspid Uk STudy NCT07133386 | Barts & The London NHS Trust | N/A |
| Not Yet Recruiting | Comparing the Effects of Newer Pacemakers and Their Effects on the Heart and Valve Function in the Short-term. NCT07534917 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | TriClip Japan Post-Approval Study NCT07509658 | Abbott Medical Devices | — |
| Not Yet Recruiting | Combined Mitral and Tricuspid Versus Isolated Mitral Transcatheter Edge-to-Edge Repair for Mitral Regurgitatio NCT07349888 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Recruiting | "TARGET 2.0 Study": Safety and Performance of the Cardiovalve TR Replacement System NCT07334691 | Cardiovalve Ltd. | N/A |
| Not Yet Recruiting | The STTAR-US Study: A Pivotal Study of Transcatheter Tricuspid Annular Repair in the US NCT06700239 | Micro Interventional Devices | N/A |
| Not Yet Recruiting | A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coup NCT07292896 | First Hospital of China Medical University | — |
| Recruiting | Early Phase Study Using the 'Pivot Extend' System as a Treatment for Patients With Tricuspid Regurgitation NCT07172477 | Tau Medical Australia Pty Ltd | N/A |
| Recruiting | Safety and Feasibility Study: Transcatheter Valve Repair in Severe Symptomatic Functional Tricuspid Regurgitat NCT07140562 | Tangent Cardiovascular Inc. | N/A |
| Recruiting | TriClip CED RWE Study NCT06920745 | Abbott Medical Devices | — |
| Recruiting | Application of Comprehensive Non-invasive Assessment To Phenotype Tricuspid Regurgitation NCT07042360 | Prince of Wales Hospital, Shatin, Hong Kong | — |
| Recruiting | Pacemaker-related Tricuspid Regurgitation Progression and Long-term Outcomes NCT06922526 | Haiyan Wang | — |
| Recruiting | TTVR STRONG Under Coverage With Evidence Development (CED) Study NCT06833476 | Edwards Lifesciences | — |
| Recruiting | Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on NCT07464106 | Robert Bosch Medical Center | — |
| Not Yet Recruiting | Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients Wi NCT06667128 | IRCCS Ospedale San Raffaele | N/A |
| Enrolling By Invitation | Band Versus Ring for Tricuspid Regurgitation NCT04093297 | Nanjing Medical University | N/A |
| Recruiting | A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Pre NCT06836011 | Medical University of Vienna | — |
| Recruiting | The Multi-center Study of Comprehensive Atrial Fibrillation Regurgitation and Recurrent Events Evaluation NCT07085650 | First Hospital of China Medical University | — |
| Not Yet Recruiting | TRICAV-II Pivotal: TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation. NCT06458907 | P+F Products + Features USA Inc. | N/A |
| Not Yet Recruiting | Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery NCT06664320 | Konkuk University Medical Center | N/A |
| Recruiting | Safety and Effectiveness Study of DragonFly-T System for Severe Tricuspid Regurgitation NCT05556460 | Hangzhou Valgen Medtech Co., Ltd | N/A |
| Enrolling By Invitation | Application of FAPI Visualization in the Assessment of Right Ventricular Dysfunction Due to Volume Overload NCT06663566 | Beijing Anzhen Hospital | — |
| Recruiting | EFS of the DUO System for Tricuspid Regurgitation NCT05913908 | CroiValve Limited | N/A |
| Active Not Recruiting | A First in Human Study for the Versa Device for Tricuspid Regurgitation NCT06368401 | Versa Vascular, Inc | N/A |
| Recruiting | Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS) NCT06212193 | Innoventric LTD | N/A |
| Recruiting | TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I) NCT06137807 | P+F Products + Features USA Inc. | N/A |
| Recruiting | Laplace Early Feasibility Study - Canada NCT07171060 | Laplace Interventional, Inc | N/A |
| Not Yet Recruiting | Concomitant Tricuspid Repair in Patients With Left Heart Surgery NCT05595187 | Nanjing Medical University | N/A |
| Recruiting | Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment o NCT05848284 | VDyne, Inc. | N/A |
| Recruiting | Early Feasibility Study (EFS) Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System NCT06183684 | Laplace Interventional, Inc | N/A |
| Withdrawn | Early Feasibility Study of the Cardiovalve System for Tricuspid Regurgitation NCT04100720 | Boston Biomedical Associates | N/A |
| Completed | Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients NCT06229886 | Northwell Health | N/A |
| Recruiting | ChAracterization of Patients and Treatment OUtcomes in Severe Tricuspid Regurgitation NCT06838611 | Medical University of Warsaw | — |
| Active Not Recruiting | Enavogliflozin Outcome Trial in Functional Tricuspid Regurgitation NCT06027307 | Asan Medical Center | Phase 3 |
| Recruiting | European Registry of Transcatheter Repair for Tricuspid Regurgitation NCT06307262 | LMU Klinikum | — |
| Recruiting | Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment NCT06033274 | Montefiore Medical Center | — |
| Enrolling By Invitation | Transcatheter Tricuspid Valve Replacement Using the Lux-Valve Plus System NCT06714500 | Prince of Wales Hospital, Shatin, Hong Kong | N/A |
| Recruiting | CT Prediction for Transcatheter Tricuspid Interventions NCT06951126 | Heart and Diabetes Center North-Rhine Westfalia | — |
| Completed | A Study to Evaluate the Safety and Performance of LuX-Valve Plus System for Tricuspid Replacement NCT05436028 | Jenscare Scientific | N/A |
| Completed | Early Discharge After Mitral and Tricuspid Edge-to-edge Repair: an Assessment of Feasibility and Safety NCT06343363 | Oxford University Hospitals NHS Trust | — |
| Recruiting | Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment o NCT05797519 | VDyne, Inc. | N/A |
| Unknown | A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Efficacy and Safety of the Transcathet NCT05770648 | Shanghai Huihe Medical Technology Co., Ltd | N/A |
| Unknown | Assessing the Right Heart Remodeling After Transcatheter Tricuspid Edge-to-edge Repair NCT06309524 | Istituto Auxologico Italiano | — |
| Recruiting | "TARGET Study": Safety and Performance of the Cardiovalve TR Replacement System NCT05486832 | Cardiovalve Ltd. | N/A |
| Unknown | Feasibility Study of the DragonFly-T System for Severe Tricuspid Regurgitation NCT05671640 | Hangzhou Valgen Medtech Co., Ltd | N/A |
| Recruiting | Prevention of Pacemaker Lead Induced Tricuspid regurgitAtion by Transesophageal eCho guidEd Implantation (PLAC NCT05667519 | LMU Klinikum | N/A |
| Enrolling By Invitation | Outcome of Patients with Severe Functional TR According to Medical, Transcatheter or Surgical Treatment NCT05825898 | Ottawa Heart Institute Research Corporation | — |
| Withdrawn | Measurement of Tricuspid Regurgitation Volume for Assessment of Tricuspid Regurgitation Using 3D Transesophage NCT05130775 | Tufts Medical Center | — |
| Active Not Recruiting | Tricuspid Regurgitation in the ElderlY NCT05784883 | Al-Azhar University | — |
| Unknown | Dawneo Neoblazar® Transcatheter Tricuspid Valve Edge-to Edge Repair System Pivotal Clinical Trial in Patients NCT05497141 | Xiamen Cardiovascular Hospital, Xiamen University | N/A |
| Active Not Recruiting | The TRICURE First in Human Trial NCT05126030 | TRiCares | N/A |
| Active Not Recruiting | A Feasibility Study of the CroíValve DUO System for Tricuspid Regurgitation NCT05296148 | CroiValve Limited | N/A |
| Active Not Recruiting | SQ-Kyrin-T First-in-man Feasibility Study NCT06605313 | Shanghai Shenqi Medical Technology Co., Ltd | N/A |
| Unknown | Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy NCT05892588 | Azienda Ospedaliero-Universitaria Careggi | — |
| Not Yet Recruiting | Confirmatory Clinical Study of Treating Tricuspid Regurgitation With K-Clip TM Transcatheter Annuloplasty Syst NCT05173233 | Shanghai Huihe Medical Technology Co., Ltd | N/A |
| Recruiting | Retrospective Prospective Multicentric Clinical Follow up of Patients After Being Treated With TricValve® NCT05114850 | P+F Products + Features GmbH | — |
| Unknown | SGLT2 Inhibitor for Severe Tricuspid Regurgitation NCT05686616 | Samsung Medical Center | N/A |
| Active Not Recruiting | Investigation of a Transcatheter Tricuspid Valved Stent Graft in Patients With Carcinoid Heart Disease NCT05064514 | Queen Mary University of London | N/A |
| Recruiting | Trisol System EFS Study NCT04905017 | Trisol Medical | N/A |
| Completed | Surgical Treatment of Tricuspid Valve Regurgitation in Patients With Cardiac Implantable Electronic Devices: L NCT05774821 | Michele De Bonis | — |
| Completed | Long-term Outcomes of Isolated Tricuspid Valve Surgery According to Preoperative Clinical and Functional Stagi NCT05721417 | Michele De Bonis | — |
| Completed | Staging Classification of Severe Tricuspid Regurgitation Using Novel Cardiac Imaging Techniques NCT05006443 | Mayo Clinic | N/A |
| Recruiting | Feasibility Study of Treating Tricuspid Regurgitation With K-ClipTM Transcatheter Annuloplasty System NCT05434507 | Shanghai Huihe Medical Technology Co., Ltd | N/A |
| Unknown | Safety and Feasibility of the Transcatheter Tricuspid Valve Repair System (Trialign) NCT04936802 | Xijing Hospital | N/A |
| Unknown | PASCAL for Tricuspid Regurgitation - a European Registry NCT05328284 | LMU Klinikum | — |
| Completed | The Long-term Course of Moderate Tricuspid Regurgitation NCT06169345 | IRCCS San Raffaele | — |
| Unknown | Hemodynamic Implications of Transcatheter Tricuspid Valve Repair in HFpEF Patients NCT04782908 | Heart Center Leipzig - University Hospital | N/A |
| Completed | Pharmacological Reduction of Right Ventricular Enlargement NCT04345796 | Asan Medical Center | Phase 3 |
| Completed | Evaluation of Tricuspid Valve Percutaneous Repair System in the Treatment of Severe Secondary Tricuspid Disord NCT04646811 | Rennes University Hospital | N/A |
| Recruiting | Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study NCT04761120 | Abbott Medical Devices | — |
| Unknown | Feasibility Study of Dragonfly System for Severe Tricuspid Regurgitation NCT04921605 | Hangzhou Valgen Medtech Co., Ltd | N/A |
| Recruiting | Pforzheim Tricuspid Valve Registry - Outcomes of Percutaneous Tricuspid Valve Repair NCT05179616 | Helios Klinikum Pforzheim | — |
| Terminated | Prehab Prior to Undergoing Tricuspid Intervention NCT04665583 | Baylor Research Institute | — |
| Recruiting | TTVR Early Feasibility Study NCT04433065 | Medtronic Cardiovascular | N/A |
| Completed | Very Long-term (>15 Years) Results of Tricuspid Valve Repair. NCT05836493 | Michele De Bonis | — |
| Recruiting | German Registry for Transcatheter Tricuspid Valve Interventions NCT04653428 | LMU Klinikum | — |
| Completed | Prevalence and Prognostic Relevance of Tricuspid Regurgitation in Different Heart Failure Entities NCT04570098 | Charite University, Berlin, Germany | — |
| Unknown | Percutaneous Edge To Edge Repair for the Treatment of Severe Tricuspid Valve Regurgitation in High-surgical Ri NCT05052177 | University of Bordeaux | — |
| Completed | Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes NCT04400513 | Eko Devices, Inc. | — |
| Active Not Recruiting | Innoventric Trillium™ Stent Graft First-in-Human (FIH) Study NCT04289870 | Innoventric LTD | N/A |
| Recruiting | Berlin Registry of Right Heart Interventions NCT04570163 | Charite University, Berlin, Germany | — |
| Recruiting | Tricuspid RegUrgitaTion Hamburg Cohort NCT04755842 | Universitätsklinikum Hamburg-Eppendorf | — |
| Unknown | Minimally Invasive Tricuspid Surgery vs Medical Treatment for Severe TR NCT04339192 | Shanghai Zhongshan Hospital | N/A |
| Completed | Tricuspid Cardiopulmonary Exercise Study NCT04559256 | Heart and Diabetes Center North-Rhine Westfalia | N/A |
| Recruiting | Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial NCT04097145 | Edwards Lifesciences | N/A |
| Active Not Recruiting | TRILUMINATE Pivotal Trial NCT03904147 | Abbott Medical Devices | N/A |
| Active Not Recruiting | Transcatheter Repair of Tricuspid Regurgitation With Edwards Cardioband TR System Post Market Study (TriBAND) NCT03779490 | Edwards Lifesciences | — |
| Completed | Edwards CLASP TR EFS NCT03745313 | Edwards Lifesciences | N/A |
| Suspended | Surgery in Secondary Tricuspid Regurgitation NCT03953755 | Saint Petersburg State University, Russia | N/A |
| Active Not Recruiting | Clinical Study of Edwards Cardioband FIT Valve Repair System NCT03382457 | Edwards Lifesciences | N/A |
| Terminated | Clinical Trial Evaluation of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System NCT03294200 | 4Tech Cardio Ltd. | N/A |
| Completed | Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation NCT03159923 | Rennes University Hospital | — |
| Recruiting | Study of Transcatheter Tricuspid Annular Repair NCT03692598 | Micro Interventional Devices | N/A |
| Completed | TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System NCT02981953 | Edwards Lifesciences | N/A |
| Completed | Comparison of Rigid Annuloplasty Ring With a Band in the Correction of Secondary Tricuspid Insufficiency NCT03144024 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Unknown | MitraClip for Severe TR NCT02863549 | LMU Klinikum | N/A |
| Recruiting | Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study) NCT06926959 | Sun Yat-sen University | — |
| Completed | Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery NCT02675244 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery NCT02502448 | Konkuk University Medical Center | N/A |
| Completed | Automated Phonocardiography Analysis in Adults NCT03600051 | CSD Labs GmbH | — |
| Recruiting | Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients NCT02537769 | University of Washington | N/A |
| Completed | Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Tr NCT02339974 | Henry Ford Health System | Phase 3 |
| Completed | The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After L NCT02644616 | Shanghai Chest Hospital | Phase 4 |
| Completed | Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™ NCT02098200 | 4Tech Cardio Ltd. | Phase 1 |
| Completed | Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation NCT01502462 | Asan Medical Center | — |
| Completed | Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery NCT02831270 | Konkuk University Medical Center | — |
| Completed | Tricuspid Regurgitation Study NCT01093001 | Mayo Clinic | Phase 4 |
| Completed | Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe T NCT01203137 | Seoul National University Hospital | — |
| Completed | Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000 NCT00665301 | Woolsthorpe Technologies, LLC | — |
| Unknown | The Impact of Right Ventricular Pacing on Tricuspid Regurgitation NCT00419354 | Rabin Medical Center | — |