| Not Yet Recruiting | Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From NCT07198880 | Assiut University | N/A |
| Recruiting | How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Pati NCT07414108 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Not Yet Recruiting | HVNI vs NIPPV in Type 2 Respiratory Failure NCT07065656 | National University Hospital, Singapore | N/A |
| Recruiting | Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Com NCT07099963 | Laval University | — |
| Recruiting | Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE NCT07432191 | Iconic Solutions By Murcia SL | N/A |
| Recruiting | Effects of Walking Apnea At Low Lung Volume on Hypoalgesia NCT06638515 | Universidad Rey Juan Carlos | N/A |
| Recruiting | Effects of Walking Apnea At High Lung Volume on Hypoalgesia NCT06638528 | Universidad Rey Juan Carlos | N/A |
| Recruiting | Respiratory Strategies in COPD Patients With Persistent Hypercapnia Following Exacerbation NCT07065799 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Recruiting | End Tidal Carbon Dioxide Concentration and Depth of Anesthesia in Children NCT06303518 | University of British Columbia | N/A |
| Unknown | Optimising Ventilatory Strategies by Using Positive Respiratory Integer Measurements NCT06298435 | University Medical Center Groningen | — |
| Unknown | Comfort of Patients Under Non Invasive Ventilation According to the Mask NCT06212180 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Effects of Walking Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function NCT06158282 | Centro Universitario La Salle | Phase 3 |
| Unknown | Effects of Walking Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function NCT06158295 | Centro Universitario La Salle | Phase 3 |
| Unknown | Effects of Static Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function NCT06150677 | Centro Universitario La Salle | Phase 3 |
| Unknown | Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function NCT06158256 | Centro Universitario La Salle | Phase 3 |
| Recruiting | Oxygen Toxicity: Mechanisms in Humans NCT05761756 | Duke University | N/A |
| Completed | Influence of Caffeine on Psychomotor Vigilance and Carbon Dioxide Tolerance During Graded Hypercapnia NCT06636825 | United States Army Research Institute of Environmental Medicine | N/A |
| Recruiting | DUET Versus Standard Interface for Hypercapnic COPD Patients NCT05829083 | Larissa University Hospital | N/A |
| Completed | Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light NCT05793437 | Affiliated Hospital of Jiaxing University | N/A |
| Recruiting | Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury NCT05536076 | VA Office of Research and Development | N/A |
| Completed | Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia NCT05948527 | Mansoura University | N/A |
| Completed | Ventilatory Effects of THRIVE During EBUS NCT05505279 | Rijnstate Hospital | Phase 3 |
| Completed | Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation NCT05470465 | Food and Drug Administration (FDA) | Phase 1 |
| Completed | Intra-abdominal Pressure and Insufflator Effects in Robotic Surgery NCT06132490 | Koç University | N/A |
| Completed | The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing NCT05441007 | Czech Technical University in Prague | N/A |
| Completed | Efficiency and Safety of Nasal Positive Airway Pressure Systems During Endoscopy NCT05972304 | University of Ulm | N/A |
| Completed | Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiaf NCT04871893 | Fresenius Medical Care Deutschland GmbH | N/A |
| Completed | Effect of FFP2 Masks on Peripheral Oxygen Saturation and Pulse Rate During the COVID-19 Pandemic NCT05188651 | Catholic University of the Sacred Heart | — |
| Terminated | Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Device Equivalence NCT04590014 | Vapotherm, Inc. | N/A |
| Completed | Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study NCT04304339 | French Society for Intensive Care | — |
| Completed | Ventilatory Responses to Hypercapnic and Hypoxic Conditions in Hyperventilants NCT05189158 | Centre Hospitalier Universitaire Saint Pierre | N/A |
| Completed | Venous Versus Arterial Blood Gas Sampling in Undifferentiated Emergency Patients NCT04409470 | University Hospital, Linkoeping | — |
| Completed | Influence of Graded Hypercapnia on Endurance Exercise Performance NCT05116397 | United States Army Research Institute of Environmental Medicine | N/A |
| Completed | Changes in Capillary Carbon Dioxide Partial Pressure (pCO2) While Wearing FFP2 / FFP3 Masks NCT04980820 | Medical University of Vienna | N/A |
| Terminated | Physiological Study to Compare Noninvasive Ventilation (NIV) Masks NCT04926805 | Fisher and Paykel Healthcare | N/A |
| Completed | End Tidal CO2 and Masks: Is There a Correlation? NCT06437301 | CHRISTUS Health | N/A |
| Completed | Evaluation of SpO2 Measurement Using a Smartwatch NCT04780724 | Czech Technical University in Prague | N/A |
| Withdrawn | Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation NCT03066115 | University of Wisconsin, Madison | Phase 1 |
| Completed | Variability of SpO2 Measurements Depending on the Choice of Finger for Sensor Placement NCT04771663 | Czech Technical University in Prague | N/A |
| Completed | Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs NCT04512781 | Vapotherm, Inc. | N/A |
| Completed | Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation NCT04310579 | Food and Drug Administration (FDA) | Phase 1 |
| Enrolling By Invitation | The Effect of Respiratory Challenge on the BOLD Signal NCT04258774 | Washington University School of Medicine | N/A |
| Completed | Triple H ODC Trial NCT04041531 | Medical University Innsbruck | N/A |
| Terminated | Non-invasive Home Ventilation in Patients With Severe Hypercapnic Chronic Obstructive Pulmonary Disease NCT03934749 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Pulse Oximeter and Respiratory Rate Test NCT03797300 | Spry Health | N/A |
| Unknown | Nasopharyngeal Airway Facilitate Transnasal Humidified Rapid Insufflation Ventilatory Exchange NCT03741998 | RenJi Hospital | N/A |
| Terminated | Impact of Non-invasive Ventilation in Hypercapnic COPD NCT03522805 | University of California, San Diego | N/A |
| Completed | Correction by ECCO2-R of Hypercapnia in Patients With DVP in Moderate to Severe ARDS Under Protective Ventilat NCT03303807 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients NCT03221387 | Temple University | N/A |
| Unknown | Postoperative Complications in Patients With Obesity Hypoventilation Syndrome NCT02980770 | Marmara University | — |
| Completed | Evaluation of the Risk of Hyperoxia-induced Hypercapnia in Obese Cardiac Surgery Patients NCT02917668 | Laval University | N/A |
| Terminated | Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the NCT02801162 | Universitair Ziekenhuis Brussel | N/A |
| Completed | The Effect of Non-invasive Ventilation on the Oxygenation of Peripheral Muscle in Hypercapnic COPD Patients NCT02877290 | Schön Klinik Berchtesgadener Land | N/A |
| Completed | The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery NCT02757573 | Tampere University Hospital | N/A |
| Completed | The Effectivity of End-tidal CO2 and Oxygen Reserve Index (ORI) Monitoring in Sedation NCT04793178 | Yuksek Ihtisas Hospital | N/A |
| Completed | Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants (VARO) NCT02429154 | Walid HABRE | N/A |
| Completed | Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation NCT04497090 | Politecnico di Milano | N/A |
| Unknown | Intrinsic Periodic Pattern of Breathing NCT02201875 | Association pour la Recherche en Physiologie de l'Environnement | — |
| Unknown | Gas Transfer on ILA-Activve NCT01997528 | Medical University of Vienna | N/A |
| Completed | CO2 Monitoring Study NCT02068274 | Cantonal Hosptal, Baselland | — |
| Completed | Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic NCT01898858 | University Hospital, Strasbourg, France | — |
| Completed | Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Mal NCT01873612 | Karolinska University Hospital | Phase 4 |
| Unknown | Suspension of Mechanical Ventilation in Ureteroscopic Lithotripsy Under General Anesthesia NCT01835600 | Chinese Medical Association | N/A |
| Completed | Trancutaneous Monitoring to Avoid Hypercapnea During Complex Catheter Ablations NCT01815034 | The Cleveland Clinic | — |
| Unknown | Use of the Medical Device DECAP CO2 for the Treatment of Hypercapnic Respiratory Distress in Patients Under No NCT01774422 | University Hospital, Clermont-Ferrand | Phase 2 |
| Completed | Alveolar Recruitment Maneuver During Cesarean Section Improves Lung Compliance NCT01826968 | General Hospital Of Pyrgos | Phase 2 |
| Completed | Hypercapnia: Cognitive Effects and Monitoring NCT01782625 | Duke University | N/A |
| Completed | Extracorporeal Lung Assist to Avoid Intubation in Patients Failing Noninvasive Ventilation for Hypercapnic ARF NCT01784367 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Closed-loop System for Oxygen Delivery and Exercise in Chronic Obstructive Pulmonary Disease NCT01575327 | AGIR à Dom | N/A |
| Unknown | STIT-2: Evaluation of Safety and Efficacy of Short-time TNI® Treatment in Patients With COPD and Hypercapnia NCT01693146 | Medical University Innsbruck | Phase 1 |
| Completed | Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury NCT01882257 | University of Michigan | N/A |
| Completed | Nocturnal Transnasal Insufflation (nTNI) NCT01499550 | Institut für Pneumologie Hagen Ambrock eV | N/A |
| Completed | Physiological and Clinical Changes in NHF Therapy NCT02504814 | University of Leipzig | N/A |
| Completed | "Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved" NCT01317329 | University of Wisconsin, Madison | N/A |
| Completed | Application of Nasal Cannula With Oxygen Versus Air During Eye Surgery Under Local Anaesthetic NCT01157624 | University of Malaya | Phase 1 |
| Completed | Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients NCT00888342 | LHL Helse | N/A |
| Completed | Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx) NCT00962078 | Schön Klinik Berchtesgadener Land | N/A |
| Completed | Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea NCT00708526 | University of Utah | N/A |
| Completed | To Determine the Efficacy of the TwinGuard in Oxygen Delivery During and Post Endoscopic Procedure NCT00619606 | Trawax Pty Limited | Phase 2 |
| Terminated | Non-invasive Ventilation in Severe Chronic Obstructive Pulmonary Disease(COPD) NCT00710541 | Deutsche Lungenstiftung e.V. | N/A |
| Completed | The Physiological Impact of N95 Masks on Medical Staff NCT00173017 | National Taiwan University Hospital | N/A |
| Completed | Role of Prostaglandins in the Regulation of Brain Blood Flow NCT00006318 | National Institutes of Health Clinical Center (CC) | — |
| Completed | Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) NCT00001845 | National Institutes of Health Clinical Center (CC) | — |