Trials / Completed
CompletedNCT05793437
Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light
Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light in Elderly Patients Undergoing Laparoscopic Surgery:A Prospective, Randomized Controlled Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 84 (actual)
- Sponsor
- Affiliated Hospital of Jiaxing University · Academic / Other
- Sex
- All
- Age
- 60 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this study is to conduct a prospective, single-center randomized controlled study to investigate the changes of plasma NFL concentration in patients undergoing laparoscopic surgery with mild hypercapnia, and further explore its impact on the central nervous system.
Detailed description
Plasma NFL concentrations were measured preoperatively and 1 day postoperatively. Secondary endpoints:CAM (Confusion Assessment Method) is conducted to check the subjects' baseline cognitive function preoperative day and 1 day postoperatively to assess whether delirium occurs.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | permissive hypercapnia | Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:45～55mmHg |
| BEHAVIORAL | normocapnia | Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35～45mmHg |
Timeline
- Start date
- 2023-04-01
- Primary completion
- 2024-01-28
- Completion
- 2024-01-28
- First posted
- 2023-03-31
- Last updated
- 2024-02-01
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT05793437. Inclusion in this directory is not an endorsement.