NCT01317329

"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"

"Reversibility of Cardiovascular Injury With Continuous Positive Airway Pressure (CPAP) Use: Mechanisms Involved"

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the factors that are associated with improved cardiovascular function with the use of CPAP therapy on subjects diagnosed with moderate to severe obstructive sleep apnea.

Detailed description

We will monitor non-invasively changes in arterial stiffness, cardiac mass, pulmonary pressures, endothelial function, etc. We will also assess the reversibility of these changes after only 5-7 days of not using the CPAP mask. In a subgroup of subjects we will explore changes in coronary flow response after 12 weeks of CPAP use compared with baseline.

Conditions

• Sleep Apnea, Obstructive
• Hypoxia
• Hypercapnia
• Sleep Disorders
• Obesity
• Hypertension
• Coronary Artery Vasospasm
• Right Ventricular Overload
• Left Ventricular Function Systolic Dysfunction
• Ventricular Hypertrophy

Interventions

Type	Name	Description
OTHER	Clinically prescribed CPAP therapy	CPAP as prescribed by attending physician

Timeline

• Start date: 2011-03-01
• Primary completion: 2014-09-01
• Completion: 2014-12-01
• First posted: 2011-03-17
• Last updated: 2020-03-06

Locations

1 site across 1 country: United States