NCT04304339

Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 862 (actual)
• Sponsor: French Society for Intensive Care · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases. Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results. Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Conditions

• Intensive Care Unit Syndrome
• Hypercapnia
• Acute Respiratory Failure

Interventions

Type	Name	Description
OTHER	Hypercapnic respiratory failure	Patients with hypercapnic respiratory failure will be followed without any additional intervention

Timeline

• Start date: 2021-12-14
• Primary completion: 2022-07-13
• Completion: 2022-07-13
• First posted: 2020-03-11
• Last updated: 2025-09-18

Locations

3 sites across 1 country: France