NCT05441007

The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing

The Effect of Hypercapnia and Hypoxia on Physiological Parameters During Short-term Breathing Experiment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Czech Technical University in Prague · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Detailed description

Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Conditions

• Hypoxia
• Hypercapnia
• Cardiac Output, High

Interventions

Type	Name	Description
OTHER	Hypoxic	Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.
OTHER	Hypercapnic	Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.
OTHER	Hypoxic and Hypercapnic	Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.

Timeline

• Start date: 2022-06-22
• Primary completion: 2024-03-30
• Completion: 2024-06-30
• First posted: 2022-07-01
• Last updated: 2026-03-11

Locations

1 site across 1 country: Czechia