Trials / Completed
CompletedNCT01873612
Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 11 (actual)
- Sponsor
- Karolinska University Hospital · Academic / Other
- Sex
- Male
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
Detailed description
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study. 6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Hypoxic ventilatory response | |
| PROCEDURE | Hypercapnic ventilatory response |
Timeline
- Start date
- 2013-05-01
- Primary completion
- 2014-09-01
- Completion
- 2014-09-01
- First posted
- 2013-06-10
- Last updated
- 2016-02-26
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT01873612. Inclusion in this directory is not an endorsement.