NCT05505279

Ventilatory Effects of THRIVE During EBUS

Does High Flow Nasal Canula (HFNC) Prevent Hypercapnia During EBUS Under Procedural Sedation?

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Rijnstate Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

High flow nasal cannula (HFNC) is used in interventional procedures to prevent hypoxia during sedation. In patients with a patent airway, HFNC reduces dead space ventilation as well. It is unknown if dead space ventilation is also reduced by HFNC in an EndoBroncheal UltraSound procedure, in which the airway is partially blocked by the endoscope. Especially in patients with Chronic Obstructive Pulmonary Disease (COPD) the partial blocking of the airway may reduce ventilation. If HFNC is able to reduce dead space during an EBUS-procedure, it may facilitate CO2 clearance, which may lead to a reduction in work of breathing. This study aims to investigate if HFNC reduces dead space ventilation in patients undergoing an EBUS-procedure and if this is flow-dependent. A randomized, double-blinded, cross-over study is designed.

Conditions

• Hypercapnia
• Sedation Complication
• High Flow Nasal Cannula

Interventions

Type	Name	Description
DEVICE	THRIVE (High Flow Nasal Cannula)	2 different rates of nasal flow compared to each other and a baseline of level of nasal oxygen

Timeline

• Start date: 2022-10-05
• Primary completion: 2024-08-08
• Completion: 2024-08-08
• First posted: 2022-08-17
• Last updated: 2024-08-15

Locations

1 site across 1 country: Netherlands