| Not Yet Recruiting | Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac NCT07457307 | NYU Langone Health | Phase 1 |
| Not Yet Recruiting | Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) NCT07206849 | Nationwide Children's Hospital | Phase 2 |
| Not Yet Recruiting | Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 / Phase 2 |
| Recruiting | Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS NCT06528691 | St. Jude Children's Research Hospital | Phase 2 |
| Not Yet Recruiting | Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors NCT07424092 | Clinica Universidad de Navarra, Universidad de Navarra | Phase 2 |
| Not Yet Recruiting | APT-weighted and Diffusion MRI for Characterizing Tumor Infiltration in High-Grade Gliomas NCT07532031 | IRCCS Ospedale San Raffaele | — |
| Not Yet Recruiting | A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Gli NCT07472790 | Beijing Bio-Targeting Therapeutics Technology Co., Ltd | Phase 1 |
| Not Yet Recruiting | Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) NCT07210632 | Eben Rosenthal | EARLY_Phase 1 |
| Not Yet Recruiting | Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) NCT07389278 | Sabine Mueller, MD, PhD | Phase 1 / Phase 2 |
| Recruiting | Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma NCT07480941 | Beijing Biotech | Phase 1 |
| Not Yet Recruiting | A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors NCT06357377 | Neonc Technologies, Inc. | Phase 1 |
| Recruiting | Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas NCT06829173 | NYU Langone Health | EARLY_Phase 1 |
| Completed | Use of Fluorescence in Gliomas NCT07499141 | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria | — |
| Withdrawn | HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma NCT04482933 | Pediatric Brain Tumor Consortium | Phase 2 |
| Recruiting | Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899 | Nationwide Children's Hospital | EARLY_Phase 1 |
| Recruiting | STARLITE for Unresectable High-Grade Gliomas NCT06428045 | University of Miami | Phase 1 |
| Recruiting | MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas NCT06712875 | Ann & Robert H Lurie Children's Hospital of Chicago | Phase 1 / Phase 2 |
| Recruiting | Atovaquone Combined With Radiation in Children With Malignant Brain Tumors NCT06624371 | Emory University | Phase 1 |
| Active Not Recruiting | IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Pediatric High-grade Glioma (HGG) NCT06946680 | University of Florida | Phase 1 |
| Recruiting | Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells NCT04254419 | Nationwide Children's Hospital | Phase 1 |
| Recruiting | Study of Olutasidenib and Temozolomide in HGG NCT06161974 | Rigel Pharmaceuticals | Phase 2 |
| Recruiting | Concurrent Azeliragon With Craniospinal Irradiation NCT06724926 | NYU Langone Health | Phase 1 |
| Recruiting | Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma NCT06831773 | Gansu Wuwei Tumor Hospital | N/A |
| Recruiting | DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma NCT06504381 | University of California, San Francisco | Phase 1 / Phase 2 |
| Not Yet Recruiting | Study of MT027 in Patients with Recurrent or Progressive High-grade Glioma NCT06737146 | Suzhou Maximum Bio-tech Co., Ltd. | Phase 1 |
| Recruiting | A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (C NCT06519682 | Daniel Morgenstern | N/A |
| Recruiting | Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma. NCT06482905 | Tcelltech Inc. | Phase 1 |
| Recruiting | Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant NCT05843253 | Nationwide Children's Hospital | Phase 2 |
| Recruiting | 18F-Fluciclovine PET-MRI in High-grade Glioma NCT05553041 | Children's Hospital of Philadelphia | EARLY_Phase 1 |
| Recruiting | Targeted Pediatric High-Grade Glioma Therapy NCT05839379 | Nationwide Children's Hospital | — |
| Recruiting | PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medullobla NCT05096481 | Nationwide Children's Hospital | Phase 2 |
| Recruiting | Fluorescence Enhanced Stereotactic Surgery (FESS) NCT07286903 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Recruiting | DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glio NCT06264388 | Ashish Shah | Phase 2 |
| Recruiting | Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progre NCT05565118 | Case Comprehensive Cancer Center | Phase 1 |
| Recruiting | Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma NCT05632562 | University of Alabama at Birmingham | EARLY_Phase 1 |
| Recruiting | A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial NCT06215495 | Zhujiang Hospital | N/A |
| Active Not Recruiting | A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors NCT06209567 | Memorial Sloan Kettering Cancer Center | EARLY_Phase 1 |
| Not Yet Recruiting | Study of Adaptive Radiotherapy for High-grade Glioma Based on Interfraction MRI NCT06201351 | West China Hospital | — |
| Withdrawn | A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patien NCT05082493 | WPD Pharmaceuticals Sp. z o.o. | Phase 1 |
| Recruiting | A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma NCT06016452 | Tata Memorial Centre | Phase 2 |
| Recruiting | GD2-CAR T Cells for Pediatric Brain Tumours NCT05298995 | Bambino Gesù Hospital and Research Institute | Phase 1 |
| Recruiting | A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) P NCT06072586 | St. Joseph's Hospital and Medical Center, Phoenix | EARLY_Phase 1 |
| Active Not Recruiting | Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG NCT05610891 | Cellectar Biosciences, Inc. | Phase 1 |
| Recruiting | Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Glio NCT06002711 | RenJi Hospital | — |
| Recruiting | Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma NCT05954858 | Northwell Health | N/A |
| Not Yet Recruiting | 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gli NCT05850377 | Sociedad de Lucha Contra el Cáncer del Ecuador | — |
| Recruiting | Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG NCT05773326 | Nader Sanai | EARLY_Phase 1 |
| Unknown | Multispectral Bimodal Fluorescence Guided Surgery of High-grade Glioma With Cetuximab-800CW and 5-ALA (5-amino NCT05929456 | University Medical Center Groningen | Phase 1 |
| Recruiting | Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors NCT05835687 | St. Jude Children's Research Hospital | Phase 1 |
| Active Not Recruiting | Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma NCT05561374 | Oblato, Inc. | Phase 1 |
| Recruiting | Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) NCT05979064 | Northwell Health | N/A |
| Recruiting | 68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma NCT05644080 | St. Olavs Hospital | N/A |
| Recruiting | Surgical Suction Aspirates Fluorescence Measurement NCT06736470 | Kuopio University Hospital | — |
| Recruiting | A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With A NCT05538130 | Pfizer | Phase 1 |
| Recruiting | Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors NCT05278208 | Nationwide Children's Hospital | Phase 1 / Phase 2 |
| Unknown | Liquid Biopsy in High-grade Gliomas and Meningiomas NCT05630664 | IRCCS San Raffaele | — |
| Recruiting | MRI in High-Grade Glioma Patients Undergoing Chemoradiation NCT05212272 | Wake Forest University Health Sciences | N/A |
| Active Not Recruiting | Circulating Tumor DNA Collection From Patients With High Grade Gliomas NCT05925218 | University Health Network, Toronto | — |
| Unknown | How the Precise Habitats Can Predict the IDH Mutation Status and Prognosis of the Patients With High-grade Gli NCT04908267 | Weiguo Zhang | — |
| Completed | Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma NCT05362409 | Alpheus Medical, Inc. | Phase 1 |
| Recruiting | A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors NCT04865315 | Maastricht Radiation Oncology | — |
| Recruiting | The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 220 NCT06118723 | Jasper Gerritsen | — |
| Active Not Recruiting | A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Ad NCT04573140 | University of Florida | Phase 1 |
| Active Not Recruiting | Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Ponti NCT04911621 | University Hospital, Antwerp | Phase 1 / Phase 2 |
| Active Not Recruiting | Study of DSP-0390 in Patients With Recurrent High-Grade Glioma NCT05023551 | Sumitomo Pharma America, Inc. | EARLY_Phase 1 |
| Completed | SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue NCT04734444 | SonoClear AS | N/A |
| Terminated | NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced NCT04851834 | Xennials Therapeutics Australia Pty Ltd | Phase 1 / Phase 2 |
| Terminated | A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and You NCT04730349 | Bristol-Myers Squibb | Phase 1 / Phase 2 |
| Completed | Contribution of Cerebral 18F-DOPA PET-CT Scan in High-grade Recurrent Gliomas NCT04766632 | Central Hospital, Nancy, France | N/A |
| Recruiting | A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion NCT04655404 | Nationwide Children's Hospital | EARLY_Phase 1 |
| Recruiting | Study of Sonodynamic Therapy in Participants with Recurrent High-Grade Glioma NCT04559685 | Nader Sanai | EARLY_Phase 1 |
| Terminated | Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection NCT04608812 | OncoSynergy, Inc. | Phase 1 |
| Completed | BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and NCT05375318 | Juan M Garcia-Gomez | — |
| Terminated | Seizures During Radiotherapy for High-grade Gliomas NCT04552756 | University Hospital Schleswig-Holstein | N/A |
| Unknown | Glioma Supra Marginal Incision Trial NCT04737577 | Sunnybrook Health Sciences Centre | N/A |
| Suspended | Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559 | University of California, San Francisco | Phase 1 |
| Recruiting | Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors NCT04299191 | Laminar Pharmaceuticals | Phase 1 / Phase 2 |
| Withdrawn | Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma NCT04220892 | Jose Carrillo | EARLY_Phase 1 |
| Terminated | Neoadjuvant Chemoradiation for Resectable Glioblastoma NCT04209790 | Geisinger Clinic | Phase 2 |
| Recruiting | C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) NCT04099797 | Baylor College of Medicine | Phase 1 |
| Terminated | Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in P NCT03971734 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 1 |
| Suspended | Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR NCT03952598 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Efficacy of Nivolumab for Recurrent IDH Mutated High-Grade Gliomas NCT03925246 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Terminated | Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG NCT03973918 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Completed | Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed H NCT04267146 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 1 / Phase 2 |
| Active Not Recruiting | Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype NCT03718767 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Glioma and Exercising NCT03775369 | University Hospital, Basel, Switzerland | N/A |
| Completed | Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001 NCT02655601 | BioMimetix JV, LLC | Phase 1 / Phase 2 |
| Terminated | REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Saf NCT03690869 | Regeneron Pharmaceuticals | Phase 1 / Phase 2 |
| Active Not Recruiting | A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Gl NCT03605550 | Nationwide Children's Hospital | Phase 1 |
| Completed | Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery NCT05873946 | Hospital del Rio Hortega | — |
| Terminated | Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas NCT03334305 | University of Florida | Phase 1 |
| Completed | Nurse-led Family and Network Consultations NCT03458312 | Rigshospitalet, Denmark | N/A |
| Unknown | Combination of Immunization and Radiotherapy for Malignant Gliomas (InSituVac1) NCT03392545 | Beijing Tiantan Hospital | Phase 1 |
| Unknown | Accelerated Hypofractionated Intensity - Modulated Radiotherapy After Hyperbaric Oxygenation for Recurrent Hig NCT03411408 | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | N/A |
| Recruiting | Dabrafenib and/or Trametinib Rollover Study NCT03340506 | Novartis Pharmaceuticals | Phase 4 |
| Terminated | Study of Dasatinib in Combination With Everolimus for Children and Young Adults With Gliomas Harboring Platele NCT03352427 | University of Michigan Rogel Cancer Center | Phase 2 |
| Completed | A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied NCT03355794 | Children's Hospital Medical Center, Cincinnati | Phase 1 |
| Completed | Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas NCT02970448 | Case Comprehensive Cancer Center | EARLY_Phase 1 |
| Terminated | Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children NCT02885324 | Indiana University | Phase 2 |
| Completed | HUMC 1612: Optune NovoTTF-200A System NCT03128047 | Hackensack Meridian Health | Phase 1 |
| Completed | Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study) NCT03294434 | CCTU- Cancer Theme | — |
| Unknown | Apatinib and Irinotecan in Treating Patients With Recurrent High-grade Glioma NCT02848794 | The First People's Hospital of Lianyungang | Phase 1 / Phase 2 |
| Terminated | A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy NCT02607124 | Children's Hospital Medical Center, Cincinnati | Phase 1 / Phase 2 |
| Terminated | Topotecan in Glioma Undergoing A Clinically-Indicated Surgical Resection NCT02500459 | Michael Vogelbaum, MD, PhD | EARLY_Phase 1 |
| Unknown | HGG-TCP (High Grade Glioma - Tumor Concentrations of Protein Kinase Inhibitors) NCT02239952 | Amsterdam UMC, location VUmc | N/A |
| Completed | Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma NCT02022644 | University of California, San Francisco | Phase 1 |
| Terminated | Study of Tumor Metabolism by Isotopic Tagging in Patients With High-grade Glioma (CARBONOMIC) NCT02305056 | University Hospital, Grenoble | Phase 1 |
| Terminated | Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors NCT01902771 | Edward Ziga | Phase 1 |
| Completed | Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma NCT01808820 | Macarena De La Fuente, MD | Phase 1 |
| Completed | Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine G NCT01644773 | St. Jude Children's Research Hospital | Phase 1 |
| Completed | Low Dose Radiation Therapy for Glioblastoma Multiforme NCT01466686 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Completed | Prospective Evaluation of T-cell Immune Status in Patients With Newly Diagnosed High Grade Gliomas NCT02041611 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | N/A |
| Unknown | Permeability Map to Distinguish Progression From Pseudoprogression in High-Grade Glioma NCT01499823 | Seoul National University Hospital | — |
| Completed | A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Ado NCT01390948 | Hoffmann-La Roche | Phase 2 |
| Completed | Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab NCT01403610 | The University of Texas Health Science Center at San Antonio | Phase 2 |
| Completed | Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas NCT01222754 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Radiation Planning Study for High Grade Brain Tumors NCT01191346 | University of Cincinnati | — |
| Completed | Personalized Translational Platform for Biomarker Discovery in Brain Tumors NCT01240161 | Marcelo F. Di Carli, MD, FACC | — |
| Terminated | Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Pa NCT00826930 | Diffusion Pharmaceuticals Inc | Phase 1 |
| Completed | Borderzone Sampling NCT00780819 | Maastricht University Medical Center | N/A |
| Completed | Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP) NCT00624728 | University Hospital, Bordeaux | Phase 1 / Phase 2 |
| Completed | A Proof-of-concept Study to Assess the Ability of [18F]AH-111585 PET Imaging to Detect Tumours and Angiogenesi NCT00565721 | GE Healthcare | Phase 2 |
| Terminated | Gliadel Wafer, Temozolomide and Radiation Therapy for Newly Diagnosed GBM NCT00548938 | Methodist Healthcare | Phase 2 |
| Completed | Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma NCT00589875 | Candel Therapeutics, Inc. | Phase 2 |
| Completed | Tumor DNA and MRI/CT Scan Findings in Patients With Grade III or Grade IV Malignant Glioma NCT00897611 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | N/A |
| Completed | Nimotuzumab in Children With HGG NCT00561873 | Oncoscience AG | — |
| Terminated | Antineoplaston Therapy in Treating Children With Recurrent or Refractory High-Grade Glioma NCT00003535 | Burzynski Research Institute | Phase 2 |
| No Longer Available | Individual Patient Compassionate Use of GX-I7 NCT04289155 | Genexine, Inc. | — |
| Withdrawn | Minimized Time to Beam in Patients With High Grade Gliomas NCT00469534 | Alberta Health services | N/A |