| Withdrawn | HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Neoplasms, High Grade Glioma, Glioblastoma Multiforme | Phase 2 | 2025-09-01 |
| Suspended | Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumo Anaplastic Astrocytoma, Diffuse Brainstem Glioma, Glioblastoma Multiforme | — | 2023-07-12 |
| Active Not Recruiting | 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Recurrent Medulloblastoma, Recurrent Ependymoma | Phase 2 | 2022-04-04 |
| Completed | INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma | Phase 1 | 2020-07-27 |
| Active Not Recruiting | A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Ab Low Grade Glioma (LGG) of Brain With BRAF Aberration, High Grade Glioma (HGG) of the Brain With BRAF Aberration, Low Grade Glioma of Brain With Neurofibromatosis Type 1 | Phase 1 / Phase 2 | 2020-01-17 |
| Terminated | Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not H Medulloblastoma, Childhood, Medulloblastoma Recurrent, Medulloblastoma | Phase 1 / Phase 2 | 2019-07-25 |
| Active Not Recruiting | Phase I Study of APX005M in Pediatric Central Nervous System Tumors Glioblastoma Multiforme, High-grade Astrocytoma Not Otherwise Specified (NOS), CNS Primary Tumor, Not Otherwise Specified (NOS) | Phase 1 | 2018-03-01 |
| Completed | Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors CNS Embryonal Tumor, Not Otherwise Specified, Malignant Glioma, Recurrent Atypical Teratoid/Rhabdoid Tumor | Phase 1 | 2018-01-13 |
| Completed | Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma Glioma | Phase 1 | 2016-06-28 |
| Terminated | Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervou Childhood Choroid Plexus Tumor, Childhood Ependymoblastoma, Childhood Grade III Meningioma | Phase 1 | 2014-12-08 |
| Terminated | Peginterferon Alfa-2b in Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Sur Childhood Craniopharyngioma | Phase 2 | 2014-04-01 |
| Terminated | Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Rem Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood Anaplastic Oligoastrocytoma, Recurrent Childhood Anaplastic Oligodendroglioma | Phase 1 | 2013-12-01 |
| Completed | p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors Teratoid Tumor, Atypical, Choroid Plexus Neoplasms, Anaplastic Astrocytoma | Phase 1 | 2013-08-01 |
| Terminated | Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors Anaplastic Astrocytoma, Anaplastic Ependymoma, Astrocytoma, Grade II | Phase 2 | 2013-03-01 |
| Completed | PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Brain and Central Nervous System Tumors | Phase 1 | 2010-11-01 |
| Withdrawn | Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiatio Brain and Central Nervous System Tumors | N/A | 2010-05-01 |
| Terminated | MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer Brain and Central Nervous System Tumors | Phase 1 | 2008-07-01 |
| Completed | Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors Brain and Central Nervous System Tumors, Neuroblastoma | Phase 1 | 2007-06-01 |
| Withdrawn | Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Brain and Central Nervous System Tumors | — | 2006-08-01 |
| Completed | Capecitabine and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Nonmetastatic Brain Stem G Brain and Central Nervous System Tumors | Phase 1 | 2006-01-01 |
| Withdrawn | Immunotoxin Therapy in Treating Children With Recurrent Malignant Gliomas Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | 2005-10-01 |
| Terminated | Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Leukemia | Phase 1 | 2005-08-01 |
| Completed | VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors Brain and Central Nervous System Tumors | Phase 1 | 2005-02-01 |
| Terminated | TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | 2004-05-01 |
| Terminated | Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma Brain and Central Nervous System Tumors | Phase 1 | 2003-03-01 |
| Completed | Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroe Brain and Central Nervous System Tumors | Phase 2 | 2002-10-01 |
| Completed | SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors Brain and Central Nervous System Tumors | Phase 1 | 2002-01-01 |
| Completed | Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children Central Nervous System Embryonal Neoplasm | — | 2001-03-01 |
| Terminated | Genetic Study of Brain Tumors in Young Children Central Nervous System Tumor, Pediatric | — | 2001-03-01 |
| Completed | Busulfan in Treating Children and Adolescents With Refractory CNS Cancer Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Leukemia | Phase 1 | 2000-11-01 |
| Terminated | SU5416 in Treating Children With Recurrent or Progressive Brain Tumors Brain and Central Nervous System Tumors | Phase 1 | 2000-08-01 |