NCT05630664

Liquid Biopsy in High-grade Gliomas and Meningiomas

Prospective Observational Study for the Implementation of Liquid Biopsy in the Follow-up of Patients With High-grade Gliomas and Meningiomas

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: IRCCS San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The general objective of this project is to evaluate the value of cell-free DNA circulating in plasma as a marker of tumor evolution in patients with high-grade gliomas and meningiomas. To this end, we propose to longitudinally collect four samples of plasma at the following time points: * T0: before surgery; * T1: one month after surgery; * T2: one month after the end of radiotherapy; * T3 at the time of radiological progression. The goal is to evaluate whether changes in plasma concentration of circulating cell-free DNA can help predict progression-free survival, overall survival, and response to therapies.

Conditions

• High Grade Glioma
• High Grade Meningioma

Timeline

• Start date: 2022-10-01
• Primary completion: 2025-09-30
• Completion: 2025-09-30
• First posted: 2022-11-30
• Last updated: 2022-12-02

Locations

5 sites across 1 country: Italy