| Not Yet Recruiting | Central Pain Mechanisms and Clinical and Psychological Factors Associated With Pain Interference in Daily Life NCT07516730 | Investigación en Hemofilia y Fisioterapia | — |
| Not Yet Recruiting | Oral Health Status and Oral Health Related Quality of Life in a Group pf Egyptian Hemophilic Children NCT07161596 | Cairo University | N/A |
| Not Yet Recruiting | 3D Ultrasound in Hemophilic Ankles NCT07452575 | The Hospital for Sick Children | N/A |
| Not Yet Recruiting | Effectiveness of an Educational Program for Pain Management in Patients With Hemophilic Arthropathy NCT07420387 | Investigación en Hemofilia y Fisioterapia | N/A |
| Recruiting | PCC Treatment for Hemophilia Patients With Inhibitor（2022PCC-A） NCT07406139 | Institute of Hematology & Blood Diseases Hospital, China | Phase 4 |
| Not Yet Recruiting | Incidence of Ultrasonographically Detected Articular Damage in Initially Healthy Joints of Patients With Hemop NCT07420348 | Investigación en Hemofilia y Fisioterapia | — |
| Not Yet Recruiting | Validity and Reliability of the Two-minute Step Test in Hemophilia NCT07425327 | Hasan Kalyoncu University | — |
| Not Yet Recruiting | Adult and Adolescent Hemophilia Patients Treated With Marstacimab: a Patient Experience Registry NCT06992076 | Institute of Hematology & Blood Diseases Hospital, China | — |
| Recruiting | A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Th NCT07285460 | Sanofi | Phase 3 |
| Not Yet Recruiting | MRI Role in Knee Hemophilic Arthopathy NCT07233122 | Assiut University | — |
| Recruiting | Monitoring of Anti-TFPI in Hemophilia NCT07101926 | Hospices Civils de Lyon | — |
| Completed | Physiotherapy to Improve Balance and Walking Capacity in Hemophilia NCT07339410 | Yuzuncu Yil University | N/A |
| Recruiting | Intra-Articular Bevacizumab for Preventing Recurrent Hemarthrosis in Hemophilia With Chronic Synovitis NCT07187661 | Khyber Medical University Peshawar | N/A |
| Completed | Central Sensitisation in Patients With Haemophilia and Degenerative Arthropathy NCT07110675 | Investigación en Hemofilia y Fisioterapia | — |
| Recruiting | Association of Prophylactic Treatment With Treatment Burden and Psychosocial Variables in Patients With Hemoph NCT07099313 | Investigación en Hemofilia y Fisioterapia | — |
| Not Yet Recruiting | Isokinetic Strength Training On Functional Performance NCT07035080 | Kafrelsheikh University | N/A |
| Not Yet Recruiting | Predictors of Physical Activity in Adult Patients With Hemophilic Arthropathy NCT06960499 | Universidad Católica San Antonio de Murcia | — |
| Recruiting | Phase III Clinical Trial of STSP-0601 for Injection in Hemophilia Patients NCT06922045 | Jiangsu BioJeTay Biotechnology Co., Ltd. | Phase 3 |
| Completed | Examination of Physiotherapists' Knowledge, Awareness and Competence on Physical Activity and Exercise in Hemo NCT06879392 | Gulhane School of Medicine | — |
| Active Not Recruiting | A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa NCT06752850 | Swedish Orphan Biovitrum | Phase 4 |
| Active Not Recruiting | EPOCH-Economics and Patient Outcomes in China in Haemophilia NCT07454239 | Institute of Hematology & Blood Diseases Hospital, China | — |
| Enrolling By Invitation | ATHNdataset Registry NCT06820515 | American Thrombosis and Hemostasis Network | — |
| Enrolling By Invitation | Comparison of Upper Extremity Functional Performance in Hemophilic and Healthy Children NCT06826209 | Hacettepe University | — |
| Recruiting | Effectiveness of an Adapted Physical Activity Program for Subjects Suffering From Haemophilia NCT06580340 | Istituto Ortopedico Rizzoli | N/A |
| Enrolling By Invitation | Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia NCT07259356 | University Hospital, Bonn | N/A |
| Completed | Comparison of Pulmonary Function, Exercise Capacity, and Physical Activity Level Between Children With Hemophi NCT06636565 | Hacettepe University | — |
| Completed | Low-Cost Platelet-Rich Plasma for Hemarthropathy NCT06543368 | University of Utah | N/A |
| Not Yet Recruiting | Canadian CHO-KLAT/H-FIT Study - Quality of Life of, and Burden of Caring for, Persons With Hemophilia NCT06191068 | The Hospital for Sick Children | — |
| Recruiting | Topical and Local TXA in Facelifts - A Randomized Controlled Double Blinded Study NCT06345833 | University of Minnesota | EARLY_Phase 1 |
| Terminated | A Phase 3 Study of the Safety and Efficacy of Coagulation Factor VIIa (Recombinant) for the Prevention of Exce NCT05695391 | Laboratoire français de Fractionnement et de Biotechnologies | Phase 3 |
| Recruiting | Conditioned Pain Modulation in Patients With Hemophilia NCT06267209 | Investigación en Hemofilia y Fisioterapia | — |
| Completed | Blood Flow Restriction in Improving Muscle Strength of Patients With Hemophilic Ankle Arthropathy NCT06261593 | Investigación en Hemofilia y Fisioterapia | N/A |
| Completed | Safety and Efficacy of STSP-0601 in Adult Patients with Hemophilia a or B with Inhibitor NCT06289166 | Staidson (Beijing) Biopharmaceuticals Co., Ltd | Phase 2 |
| Completed | Changes in Intra-articular Parameters by Doppler Ultrasound in Patients With Hemophilic Ankle Arthropathy NCT06281340 | Investigación en Hemofilia y Fisioterapia | N/A |
| Unknown | Blood Flow Restriction in Improving Muscle Strength of Patients With Hemophilic Knee Arthropathy NCT06261632 | Investigación en Hemofilia y Fisioterapia | N/A |
| Completed | Resistance Training With Blood Flow Restriction in Hemophilia NCT05568524 | University of Valencia | N/A |
| Completed | Retrospective Experience Assessing the Real-World Utilization and Effectiveness of SEVENFACT® NCT05904210 | Laboratoire français de Fractionnement et de Biotechnologies | — |
| Completed | SS109 and NovoSeven ® PK / PD Profile, and Preliminary Efficacy and Safety of SS109 on Demand Treatment NCT06010953 | Jiangsu Gensciences lnc. | Phase 1 / Phase 2 |
| Unknown | Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease NCT06014320 | Stanford University | — |
| Completed | Restricting Blood Flow in Improving Muscle Strength in Patients With Hemophilic Arthropathy NCT05039008 | Investigación en Hemofilia y Fisioterapia | N/A |
| Recruiting | High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT) NCT07205523 | Yigeng Cao,MD,PhD | — |
| Unknown | Viscoelastic Properties of Lower Extremity Muscles in Patients With Hemophilia NCT05981313 | Hasan Kalyoncu University | — |
| Completed | A Proof-of-concept Study to Reduce Treatment Burden in Haemophilia Participants Receiving Factor VIII and Fact NCT05437211 | Takeda | N/A |
| Unknown | Reliability and Validity of the Turkish Version of the PedHAL NCT05889754 | Hasan Kalyoncu University | — |
| Active Not Recruiting | A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adoles NCT05662319 | Sanofi | Phase 3 |
| Recruiting | Embolization in Hereditary Coagulopathies NCT05629130 | University of Sao Paulo General Hospital | N/A |
| Completed | Safety and Efficacy of STSP-0601 in Adult Patients With Hemophilia A or B Without Inhibitor NCT05619926 | Staidson (Beijing) Biopharmaceuticals Co., Ltd | Phase 2 |
| Completed | Learning to Live With Non-severe Haemophilia NCT05314751 | Haemnet | — |
| Active Not Recruiting | He-move-philia, Lifestyle Intervention for Patients With Hemophilia NCT05608863 | Radboud University Medical Center | N/A |
| Completed | Manual Therapy in the Treatment of Hemophilic Arthropathy of the Ankle NCT05549843 | Investigación en Hemofilia y Fisioterapia | N/A |
| Completed | A Phase 1b Study to Assess the Safety, Tolerability, PK and PD of MG1113 in Hemophilia Patient NCT05493631 | GC Biopharma Corp | Phase 1 |
| Completed | KN057 Multiple Dose Study in Moderately Severe to Severe Hemophilia NCT05421429 | Suzhou Alphamab Co., Ltd. | Phase 2 |
| Completed | Impact of Moderate Intensity Physical Activities on PK-guided EHL FVIII Concentrates Prophylaxis Severe HA Pat NCT05728528 | Chulalongkorn University | Phase 4 |
| Unknown | Combination Regimen With Sodium Valproate for Severe Hemophilia: a Single-arm, Phase 1, Pilot Trial. NCT05920512 | Xue-chun Lu | Phase 1 / Phase 2 |
| Recruiting | Chronic Pain and Hemophilia NCT05202951 | University Hospital, Clermont-Ferrand | — |
| Not Yet Recruiting | The World Federation of Hemophilia Gene Therapy Registry NCT04883710 | World Federation of Hemophilia | — |
| Completed | Hemophilic Knee Arthropathy Virtual Reality NCT05802368 | Maged Basha | N/A |
| Completed | A Safety and Efficacy Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor NCT05027230 | Staidson (Beijing) Biopharmaceuticals Co., Ltd | Phase 1 / Phase 2 |
| Completed | In Vitro Correction of Thrombin Generation by Concizumab (Anti-TFPI) for Severe Hemophilia Patients NCT05617209 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Posture Analysis for Patients With Haemophilia NCT05173129 | Cukurova University | N/A |
| Completed | Safety and Efficacy in a ReAl-Life Study in Patients With Haemophilia Treated wIth NovoEight® for Surgery NCT04808349 | Nantes University Hospital | — |
| Completed | Are There Differences Between Carriers of Haemophilia A and B? NCT05217992 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | — |
| Recruiting | Trial of an Exercise Intervention for Children With Haemophilia NCT05895032 | East Kent Hospitals University NHS Foundation Trust | N/A |
| Completed | Protection of Knee Joints in Bleeding Disorder Patients NCT06039904 | Ramathibodi Hospital | N/A |
| Terminated | Therapeutic Exercise in Patients With Hemophilia NCT04114448 | University of Seville | N/A |
| Completed | Vitamin D Deficiency and Body Composition in the Patients With Hemophilia NCT05517070 | Tsung-Ying Li | — |
| Recruiting | National Longitudinal Cohort of Hematological Diseases NCT04645199 | Institute of Hematology & Blood Diseases Hospital, China | — |
| Recruiting | ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders NCT04398628 | American Thrombosis and Hemostasis Network | — |
| Completed | Self-myofascial Release in Hemophilic Ankle Arthropathy NCT05104164 | Investigación en Hemofilia y Fisioterapia | N/A |
| Completed | An Exploration of the Impact of Gene Therapy on the Lives of People With Haemophilia and Their Families NCT04723680 | Haemnet | — |
| Completed | Medication Exposure in Older Patients With Constitutional Hemorrhagic Disease NCT04282486 | Hospices Civils de Lyon | — |
| Unknown | Observational Study of Long-Term Joint Health Outcome in Hemophilia Patient NCT04618237 | Taipei Medical University Hospital | — |
| Recruiting | Haemophilia and Bone Loss - PHILEOS Study NCT04384341 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Unknown | A Study of Factor Inhibitors in Adult Patients With Hemophilia and Von Willebrand's Disease in Upper Egypt NCT04106323 | Safaa AA Khaled | — |
| Unknown | Movement Visualization in Patients With Hemophilic Arthropathy NCT04237766 | Real Fundación Victoria Eugenia | N/A |
| Unknown | The Effectiveness of Recombinant Coagulation Factor IX With Recombinant Albumin (rIX-FP) in Severe Hemophilia NCT04108260 | National Taiwan University Hospital | Phase 4 |
| Completed | COVID-19 Related Lockdown Effects On Chronic Diseases NCT04390126 | Centre Hospitalier Universitaire Dijon | — |
| Recruiting | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Stan NCT04278404 | Duke University | — |
| Completed | The Effects of Exercise Training in Children With Hemophilia NCT04703062 | Istanbul University - Cerrahpasa | N/A |
| Completed | Self-myofascial Release With Foam Roller in Patients With Hemophilic Ankle Arthropathy NCT03914287 | Investigación en Hemofilia y Fisioterapia | N/A |
| Active Not Recruiting | Fitusiran Prophylaxis in Male Pediatric Subjects Aged 1 to Less Than 12 Years With Hemophilia A or B NCT03974113 | Genzyme, a Sanofi Company | Phase 3 |
| Completed | A Safety Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor NCT04747964 | Staidson (Beijing) Biopharmaceuticals Co., Ltd | Phase 1 |
| Completed | Hemophilia and Bone Metabolism: Study of Monocytic Populations and Inflammatory Proteins NCT04206033 | Nantes University Hospital | — |
| Completed | MOTHIF II : THERAPEUTIC MANAGEMENT AND USE OF CLOTTING FACTORS IN HEMOPHILIA A & B IN FRANCE II NCT03596814 | Nantes University Hospital | — |
| Withdrawn | Study to Test the Safety of an Investigational Drug Given Repeatedly to Adult Men With Severe Hemophilia NCT03996486 | Bayer | Phase 1 |
| Completed | A Study to Investigate the Safety, Tolerability, PK and PD of MG1113 in Healthy Subjects and Hemophilia Patien NCT03855696 | Green Cross Corporation | Phase 1 |
| Active Not Recruiting | Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B, With or Without Inhibitor NCT03754790 | Genzyme, a Sanofi Company | Phase 3 |
| Completed | Sarcopenia and Osteoporosis in the Patients With Hemophilia NCT04535180 | Tri-Service General Hospital | — |
| Completed | ATHN 8: Previously Untreated Patients (PUPs) Matter Study NCT03818529 | American Thrombosis and Hemostasis Network | — |
| Completed | A Study of Fitusiran in Severe Hemophilia A and B Patients Previously Receiving Factor or Bypassing Agent Prop NCT03549871 | Genzyme, a Sanofi Company | Phase 3 |
| Completed | The Effects of Manual Therapy in Hemophilic Patients NCT04309903 | Necmettin Erbakan University | N/A |
| Completed | Gait Examination in Patients With Hemophilia in Austria NCT03541811 | FH Campus Wien, University of Applied Sciences | — |
| Completed | Effectiveness of Manual Therapy and Strengthening Exercises in Hemophilic Arthropathy of the Elbow Joint NCT04308876 | Necmettin Erbakan University | N/A |
| Completed | Imaging of Arthropathy in Boys With Hemophilia in China NCT03914716 | Andrea Doria | N/A |
| Completed | The Effects of Core Stabilization Exercises in Addition to Balance Exercises in Adult Hemophilia Patients on B NCT03574922 | Hacettepe University | N/A |
| Completed | Extended Half Life Factor (EHF) Products For Heavy Menstrual Bleeding in Hemophilia Carriers NCT03272568 | Emory University | EARLY_Phase 1 |
| Completed | Fascial Therapy in Elbow Hemophilic Arthropathy NCT03009591 | Real Fundación Victoria Eugenia | N/A |
| Completed | Evaluation of Static Postural Balance in Children With Hemophilia and Its Relationship With Joint Health NCT04406519 | Necmettin Erbakan University | — |
| Completed | What is the Feasibility of the ISTEP Exercise Test in Boys With Haemophilia NCT04076306 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Completed | PET Imaging of Hemophilic Arthropathy NCT03485170 | Tri-Service General Hospital | N/A |
| Completed | The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A a NCT03623295 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Patient Reported Outcomes Burdens and Experiences - Phase 3 NCT03549858 | McMaster University | — |
| Completed | Bleeding Risk Evaluation in Haemophilia Patients Under Antiplatelet Therapies NCT03157154 | Nantes University Hospital | — |
| Unknown | Hemophilia Mobile App Usability Pilot NCT03168685 | Healthcare Innovation Technology Lab | N/A |
| Unknown | Does the Thrombin Generation Test Performed During the Pharmacokinetic Profile of the Substitutive Factor VIII NCT02803502 | Brugmann University Hospital | N/A |
| Completed | Pharmacokinetic Characterization of the Hemophilia A Population in Spain Using myPKFiT® NCT03006965 | Spanish Society of Thrombosis and Haemostasis | — |
| Completed | LR769 in Congenital Hemophilia Patients With Inhibitors Undergoing Elective Surgery or Invasive Procedures NCT02548143 | Laboratoire français de Fractionnement et de Biotechnologies | Phase 3 |
| Withdrawn | Improved Factor VIII Inhibitor Evaluation NCT02726139 | Boston VA Research Institute, Inc. | — |
| Terminated | Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy NCT02569359 | Tri-Service General Hospital | N/A |
| Completed | Risk Models to Optimise Prophylaxis Schedules in Children With Haemophilia NCT02585635 | Neuroscience Research Australia | — |
| Completed | Health Practice of Hemophilia Patiente Care During Pregnancy, Delivery and Newborn Children NCT03360149 | University Hospital, Brest | — |
| Unknown | Myofascial Therapy in Patients With Hemophilic Arthropathy NCT02433782 | Universidad Católica San Antonio de Murcia | N/A |
| Unknown | Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia NCT02165592 | Universidad Católica San Antonio de Murcia | — |
| Terminated | Weight-based Dosing in Hemophilia A NCT02586012 | Craig Seaman | Phase 2 |
| Completed | Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy NCT02165462 | Universidad Católica San Antonio de Murcia | — |
| Completed | ATHN 2: Factor Switching Study NCT02546622 | American Thrombosis and Hemostasis Network | — |
| Completed | Patient Reported Outcomes Burdens and Experiences - Phase 2 NCT02439710 | McMaster University | — |
| Unknown | The Effect of Functional Activities and Balance Ability With Taping in Subjects of Hemophilia NCT02389205 | Tri-Service General Hospital | N/A |
| Recruiting | Global Haemostatic Methods Following Administration of Bypassing Agents to Patients With Haemophilia With Inhi NCT02453542 | Karolinska Institutet | — |
| Unknown | Outcomes of Prophylaxis and On-demand Treatment for Severe Hemophiliacs and Collection of Baseline Data in Hem NCT02908243 | Taiwan Society of Thrombosis and Hemostasis | — |
| Completed | Prospective Biomarkers of Bone Metabolism in Hemophilia A NCT02306694 | Oregon Health and Science University | Phase 3 |
| Terminated | A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipun NCT02402829 | Children's Mercy Hospital Kansas City | — |
| Unknown | Allogenic Bone Marrow Derived Mesenchymal Stem Cell Therapy in Cases of Hemophilia NCT02108132 | Cairo University | Phase 1 |
| Unknown | Individualized Prophylaxis for Severe Hemophilia A Children NCT02116855 | Beijing Children's Hospital | N/A |
| Completed | Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy NCT02601170 | Tri-Service General Hospital | N/A |
| Terminated | Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis NCT02060305 | National Taiwan University Hospital | Phase 1 |
| Completed | Motor Proficiency of People With Bleeding Disorders Using the BOT-2 (TM) NCT02279199 | Oregon Health and Science University | — |
| Completed | Comparison of Efficacy, Safety and Costs of Recombinant FVIII Products Between On-demand and Secondary Prophyl NCT01817868 | Bayer | — |
| Completed | Viral Kinetics in HCV Clearance in Subjects With Hemophilia NCT01704521 | Kenneth Sherman | Phase 1 |
| Completed | Efficacy of Strength Training in Improving Elbow Range of Motion and Function in Adults With Hemophilia NCT03842605 | Oregon Health and Science University | N/A |
| Completed | A Phase I Safety, Pharmacokinetics and Pharmacodynamics Study of Recombinant Factor VIIa in Adult Patients Wit NCT01708564 | rEVO Biologics | Phase 1 |
| Completed | Tissue Factor Pathway Inhibitor (TFPI) and Haemorrhagic Manifestations in Haemophilia A and B Patients NCT02540187 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care NCT01431326 | Daniel Benjamin | — |
| Terminated | First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients NCT01191372 | Baxalta now part of Shire | Phase 1 |
| Completed | Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles NCT01232634 | The Hospital for Sick Children | — |
| Unknown | Study of an Intervention to Improve Problem List Accuracy and Use NCT01105923 | Brigham and Women's Hospital | N/A |
| Completed | Bleeding Symptoms of Carriers of Hemophilia A and B NCT01029808 | Sahlgrenska University Hospital | — |
| Completed | Joint Outcome Study Continuation for Children With Severe Factor VIII Deficiency NCT01000844 | University of Colorado, Denver | — |
| Completed | Study Evaluating Liver Transplantation in Haemophilia Patients in Spain NCT00927992 | Wyeth is now a wholly owned subsidiary of Pfizer | — |
| Completed | A Feasibility Study to Collect Data in Patients With Haemophilia NCT00798499 | AstraZeneca | — |
| Completed | Pegasys® Plus Ribavirin in Hemophilic Patients With Hepatitis C Virus Infection NCT00707772 | Baqiyatallah Medical Sciences University | Phase 4 |
| Withdrawn | Kid Cards: Teaching Kids About Medicines NCT00127543 | Children's Mercy Hospital Kansas City | N/A |
| Completed | Genetic Susceptibility to Factor VIII Inhibitors NCT00344435 | National Cancer Institute (NCI) | — |
| Completed | BAY14-2222 Continuous Infusion in Surgeries NCT00606060 | Bayer | Phase 3 |
| Unknown | Musculoskeletal Function in Hemophilia NCT00324493 | Christian Medical College, Vellore, India | — |
| Completed | The Use of Cyclokapron for Treatment and Management of Women With Bleeding Disorders NCT00697385 | Mary M. Gooley Hemophilia Center | N/A |
| Terminated | Host Genetic Factors Influencing HIV1 and HCV Viral Loads and AIDS Clinical Progression in a Hemophilia Cohort NCT00340548 | National Cancer Institute (NCI) | — |
| Completed | Treatment of Hepatitis C in Hemophilic Patients With HIV NCT00055341 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | Clinical Trial of Factor XIII (FXIII) Concentrate NCT00640289 | Children's Hospital of Orange County | N/A |