Clinical Trials Directory

Trials / Sponsors / Baxalta now part of Shire

Baxalta now part of Shire

Industry · 111 registered clinical trials1 currently recruiting.

StatusTrialPhaseStarted
CompletedA Study of ADVATE in People With Hemophilia A in India
Hemophilia A
Phase 42022-01-14
CompletedA Study to Assess the Tolerability, Safety, and Pharmacokinetics of Subcutaneous Immune Globulin Infusion 10%
Healthy Volunteers
Phase 12020-10-27
CompletedA Study of Immune Globulin Subcutaneous (Human), 20% Solution (IGSC, 20%) in Japanese Participants With Primar
Primary Immunodeficiency Diseases (PID)
Phase 32020-08-11
Active Not RecruitingA Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia A
Hemophilia A
2020-07-09
TerminatedA Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects
Hemophilia B
Phase 1 / Phase 22020-05-13
CompletedA Study of Recombinant Von Willebrand Factor (rVWF) in Pediatric and Adult Participants With Severe Von Willeb
Von Willebrand Disease (VWD)
Phase 32019-04-01
CompletedFEIBA Reconstitution Volume Reduction and Faster Infusion Study (FEIBA STAR)
Hemophilia A or B With Inhibitors
Phase 32019-02-12
CompletedRIXUBIS PMS India (RIXUBIS PMS)
Hemophilia B
Phase 42018-12-07
CompletedReal-world CANadian CUvitru Non-Interventional Study in Subjects Transitioning From Subcutaneous Immunoglobuli
Primary Immunodeficiency Diseases (PID)
2018-09-24
CompletedProspective Psychometric Evaluation Study of a Patient-reported Outcomes (PRO) Instrument for Congenital Throm
Congenital Thrombotic Thrombocytopenic Purpura
2018-07-12
CompletedA Study of BAX 888 in Male Adults With Severe Hemophilia A
Hemophilia A
Phase 1 / Phase 22018-02-27
RecruitingA Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebr
Von Willebrand Disease
Phase 32017-11-06
CompletedA Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic Thrombocytopenic Purpura (TTP)
Phase 32017-10-13
CompletedEfficacy, Safety, Tolerability, Immunogenicity and Pharmacokinetic Evaluation of HYQVIA in Pediatric PIDD Subj
Primary Immunodeficiency Diseases (PID)
Phase 32017-09-25
CompletedGlobal Epidemiologic Study of Preexisting Immunity to AAV in Adults With Severe Hemophilia
Hemophilia A, Hemophilia B
2017-06-14
CompletedPost-Authorization Safety, Tolerability and Immunogenicity Evaluation of HyQvia in Pediatric PIDD Subjects
Primary Immunodeficiency Diseases (PID)
Phase 42017-05-30
TerminatedA Phase 2/3 Study of GLASSIA for the Treatment of Acute GvHD
Graft Versus Host Disease
Phase 2 / Phase 32017-04-26
CompletedNon-Interventional Study to Capture the Patient Experience on Gene Therapy for Hemophilia Within the AskBio009
Hemophilia B
2017-03-31
CompletedPost-Marketing Surveillance (Usage Results Study) of RIXUBIS in Adult and Pediatric Patients With Haemophilia
Hemophilia B
2017-01-06
TerminatedBAX 802 in CHA With Inhibitors
Hemophilia A
Phase 32016-12-22
CompletedProspective and Retrospective, Non-interventional Study to Evaluate the Safety and Effectiveness of Obizur in
Acquired Hemophilia A
2016-12-14
CompletedRIXUBIS Drug Use-Result Survey (Japan)
Hemophilia B
2016-11-16
CompletedLong-Term Tolerability and Safety of HYQVIA/HyQvia in CIDP
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Phase 32016-11-14
TerminatedStage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency
Chronic Obstructive Pulmonary Disease, Alpha1-antitrypsin Deficiency
Phase 32016-11-02
CompletedGAS-Hem Feasibility Study
Hemophilia A
2016-08-05
CompletedGLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study
Alpha1-antitrypsin Deficiency
Phase 32016-03-08
CompletedBAX 826 Dose-Escalation Safety Study
Hemophilia A
Phase 12016-03-03
WithdrawnEfficacy and Safety of SM101 in the Treatment of IgA Nephropathy
Immunoglobulin A Nephropathy
Phase 22015-12-31
CompletedPost-Marketing Non-Interventional Safety Evaluation of Obizur in the Treatment of Bleeding Episodes for Patien
Acquired Hemophilia A
2015-12-30
CompletedRetrospective Chart Review to Evaluate Safety and Tolerability of ADVATE Among Previously Untreated Patients i
Hemophilia A
2015-12-23
CompletedA Study of HyQvia and Gammagard Liquid (Kiovig) in Adults With Chronic Inflammatory Demyelinating Polyradiculo
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Phase 32015-12-15
CompletedPregnancy Registry to Collect Long-Term Safety Data From Women Treated With HyQvia
Exposure During Pregnancy
2015-12-04
WithdrawnA Phase II Non-Controlled, Open-Label, Efficacy, Safety, Pharmacokinetic, and Pharmacodynamic Study of Pacriti
Primary Myelofibrosis
Phase 22015-11-30
CompletedBAX 855 PK-guided Dosing
Hemophilia A
Phase 32015-11-23
CompletedA Study of PEGylated Recombinant Factor VIII (BAX855) in Previously Untreated Young Children With Severe Hemop
Hemophilia A
Phase 32015-11-12
CompletedNon-Interventional Post-Marketing Safety Study on the Long-Term Safety of HYQVIA (Global)
Primary Immunodeficiency Diseases (PID)
2015-11-12
TerminatedPhase 1/2a Two-Arm Dose-Escalation Study of BAX69 in Subjects With Malignant Ascites of Ovarian Cancer
Refractory Ovarian Cancer With Recurrent Symptomatic Malignant Ascites
Phase 1 / Phase 22015-11-02
TerminatedPhase 2a Study of BAX69 and 5-FU/Leucovorin or Panitumumab Versus Standard of Care in Subjects With Metastatic
Metastatic Colorectal Cancer
Phase 22015-06-15
CompletedRecombinant Von Willebrand Factor in Subjects With Severe Von Willebrand Disease Undergoing Surgery
Von Willebrand Disease
Phase 32015-04-01
CompletedBAX 855 Pediatric Study
Hemophilia A
Phase 32014-10-31
CompletedPhase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Throm
Hereditary Thrombotic Thrombocytopenic Purpura (TTP)
Phase 12014-09-30
CompletedStudy of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE
Hemophilia A, Hemophilia B
2014-07-22
CompletedChina ADVATE PTP Study
Hemophilia A
Phase 42014-06-26
CompletedPhase 3 Efficacy and Safety Study of BAX 855 in Severe Hemophilia A Patients Undergoing Surgical Procedures
Hemophilia A
Phase 32013-12-20
TerminatedEvaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease
Sickle Cell Disease
Phase 22013-12-03
CompletedBAX 855 Continuation
Hemophilia A
Phase 32013-10-15
CompletedADVATE 2 mL Post-Authorization Safety Surveillance (PASS)
Hemophilia A, Congenital Factor VIII (FVIII) Deficiency
2013-09-20
CompletedRecombinant Factor VIIa BI (rFVIIa BI) Treatment of Acute Bleeding Episodes Per an On-demand Regimen
Hemophilia A, Hemophilia B
Phase 32013-02-20
Active Not RecruitingOpen-Label Single Ascending Dose of Adeno-associated Virus Serotype 8 Factor IX Gene Therapy in Adults With He
Hemophilia B
Phase 1 / Phase 22013-02-11
CompletedStudy Investigating a PEGylated Recombinant Factor VIII (BAX 855) for Hemophilia A (PROLONG-ATE Study)
Hemophilia A
Phase 2 / Phase 32013-01-31
CompletedPhase 2/3 Study of IGSC, 20% in PIDD
Primary Immunodeficiency Diseases (PID)
Phase 2 / Phase 32013-01-28
TerminatedLong-Term Study of IGIV, 10% in Alzheimer´s Disease
Alzheimer´s Disease
Phase 32012-11-29
CompletedGLASSIA Infusion Rate Study
Alpha1-antitrypsin Deficiency, Healthy Volunteers
Phase 42012-07-31
CompletedPhase 1 Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Solid Tumors
Metastatic Adenocarcinoma of the Colon or Rectum, Malignant Solid Tumors
Phase 12012-06-14
CompletedA Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subje
Sickle Cell Disease
Phase 12012-05-12
TerminatedPhase 3 IGIV, 10% in Alzheimer´s Disease
Alzheimer´s Disease
Phase 32012-01-23
CompletedTolerability and Safety of IGI, 10% With rHuPH20 in PIDD
Primary Immunodeficiency Diseases (PID)
Phase 2 / Phase 32011-12-29
CompletedBAX 326 Pediatric Study
Hemophilia B
Phase 2 / Phase 32011-12-20
CompletedBAX 326 Surgery Study in Hemophilia B Patients
Hemophilia B
Phase 32011-12-19
TerminatedSafety Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Lupus Nephritis
Systemic Lupus Erythematosus
Phase 12011-11-28
CompletedPharmacokinetics, Safety and Efficacy of Recombinant Von Willebrand Factor (rVWF) in the Treatment of Bleeding
Von Willebrand Disease
Phase 32011-11-01
TerminatedOsteoporosis and MRI Study in Hemophilia
Bone Mineral Density, Hemophilia A, Hemophilia B
N/A2011-10-30
TerminatedStudy of Modified Recombinant Factor VIII (OBI-1) in Subjects With Congenital Hemophilia A
Hemophilia A
Phase 32011-10-03
CompletedBAX 855 Dose-Escalation Safety Study
Hemophilia A
Phase 12011-09-30
TerminatedEarly Prophylaxis Immunologic Challenge (EPIC) Study
Hemophilia A
Phase 32011-08-26
CompletedADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)
Hemophilia A
2011-06-28
CompletedImmune Globulin Subcutaenous (Human), 20%
Primary Immunodeficiency Diseases (PID)
Phase 2 / Phase 32011-06-20
CompletedBAX 326 (rFIX) Continuation Study
Hemophilia B
Phase 32011-04-12
CompletedPhase 1/2 Lyme Vaccine Study
Prophylaxis of Lyme Borreliosis
Phase 1 / Phase 22011-03-01
CompletedStudy of Modified Recombinant Factor VIII (OBI-1) in Subjects With Acquired Hemophilia A
Acquired Hemophilia A
Phase 2 / Phase 32010-11-10
TerminatedFirst-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients
Hemophilia
Phase 12010-09-15
CompletedPivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patients
Hemophilia B
Phase 32010-07-29
CompletedTolerability and Safety of Immune Globulin Subcutaneous Solution (IGSC) and rHuPH20 in PID
Primary Immunodeficiency Diseases (PID)
Phase 32010-07-28
CompletedEfficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal
Prothrombin Complex Factor Deficiency
Phase 42010-07-09
CompletedCeprotin Treatment Registry
Protein C Deficiency
2010-06-23
CompletedIMMUNINE Pre-Treatment Study
Hemophilia B
Phase 42010-05-31
CompletedPhase 1 Dosing Study of BAX 513 in Healthy Volunteers
Healthy Volunteers
Phase 12010-01-29
CompletedPharmacokinetic Study of ADVATE 3000 IU in Previously Treated Patients With Severe Hemophilia A
Hemophilia A
Phase 42009-06-29
CompletedEfficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia
Hemophilia A or B With Inhibitors, Hemophilia A, Hemophilia B
Phase 32009-03-31
CompletedA Phase 3 Study Evaluating Safety and Effectiveness of Immune Globulin Intravenous (IGIV 10%) for the Treatmen
Alzheimer´s Disease
Phase 32008-12-19
CompletedGammagard Liquid and rHuPH20 in PID
Primary Immunodeficiency Diseases (PID)
Phase 32008-12-18
CompletedPharmacokinetic, Safety and Tolerability Study of Recombinant Von Willebrand Factor / Recombinant Factor VIII
Von Willebrand Disease
Phase 12008-12-01
CompletedStudy of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropat
Multifocal Motor Neuropathy
Phase 32008-08-22
CompletedPharmacokinetic Study of ADVATE Reconstituted in 2 mL Sterile Water for Injection
Hemophilia A
Phase 12008-08-08
CompletedPharmacokinetic Comparison of Advate rAHF-PFM With Recombinate rAHF in Patients With Severe Hemophilia A
Hemophilia A
Phase 42008-03-31
CompletedA Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly
Healthy Volunteers
Phase 12007-12-01
CompletedComparison of Intravenous and Subcutaneous Administration of IGIV, 10% in Primary Immunodeficiency (PID) Subje
Primary Immunodeficiency Diseases (PID)
Phase 2 / Phase 32007-10-03
CompletedPharmacokinetic (PK) and Safety Study of Plasma-derived Human Butyrylcholinesterase Administered Intravenously
Healthy Volunteers, Chemical Terrorism, Chemical Warfare
Phase 12007-01-01
CompletedStudy to Determine the Dose of Recombinant Human Hyaluronidase Needed to Infuse a Full Dose of IGIV Subcutaneo
Primary Immunodeficiency Diseases (PID)
Phase 1 / Phase 22006-12-04
CompletedEfficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhib
Alpha 1-Antitrypsin Deficiency
Phase 42006-10-27
TerminatedAralast alpha1-proteinase Inhibitor Surveillance Study
Alpha1-antitrypsin Deficiency
Phase 42006-06-09
CompletedPhase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus
Hemophilia A
Phase 42006-05-29
CompletedDose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophili
Hemophilia A
Phase 42006-02-02
CompletedProphylaxis Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia
Hemophilia A
Phase 42006-01-04
CompletedPharmacokinetic Study of ARALAST (Human Alpha1- PI)
Alpha 1-Antitrypsin Deficiency
Phase 12005-12-20
CompletedRetrospective Study to Capture Dosing and Treatment Outcome Data in Participants With Severe Congenital Protei
Protein C Deficiency
2005-06-01
CompletedEfficacy and Safety Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Pediatric Patients in Ca
Hemophilia A
Phase 2 / Phase 32004-12-17
CompletedADVATE Post Authorization Safety Surveillance
Hemophilia A
2004-10-14
CompletedEfficacy and Safety Study of a Recombinant Protein-Free Manufactured Factor VIII (rAHF-PFM) in Previously Untr
Hemophilia A
Phase 32004-04-01
CompletedStudy of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Sub
Alpha1-antitrypsin Deficiency
Phase 1 / Phase 22004-03-01
CompletedEfficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C Deficiency
Protein C Deficiency
Phase 2 / Phase 32003-08-22
CompletedPharmacokinetics, Efficacy and Safety Study of IMMUNATE SD (Human Plasma-Derived Coagulation Factor VIII Conce
Hemophilia A
Phase 32003-03-31
CompletedEfficacy and Safety Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solution in Adult Subjec
Immune Thrombocytopenic Purpura (ITP)
Phase 22003-01-13
CompletedSafety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficienc
Alpha1-antitrypsin Deficiency
Phase 1 / Phase 22003-01-07
CompletedSafety and Efficacy Study of a 10% Intravenous Immune Globulin Solution in Subjects With Primary Immunodeficie
Primary Immunodeficiency Diseases (PID), Immune Thrombocytopenic Purpura (ITP), Kawasaki Syndrome
Phase 32002-06-25
CompletedSafety, Pharmacokinetic and Efficacy Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solutio
Primary Immunodeficiency Diseases (PID), Agammaglobulinemia, Hypogammaglobulinemia
Phase 22002-06-13
CompletedStudy of Pharmacokinetics, Efficacy, and Safety of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Pe
Hemophilia A
Phase 2 / Phase 32002-06-07
CompletedStudy of Pharmacokinetics, Efficacy and Safety of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Hem
Hemophilia A
Phase 2 / Phase 32001-11-22
CompletedSafety and Efficacy Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Hemophilia A Patients Un
Hemophilia A
Phase 2 / Phase 32001-02-12
TerminatedPrevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Pe
Leukemia, Lymphoma, Graft Versus Host Disease
Phase 31997-04-01
No Longer AvailableExpanded Access to B-Domain Deleted Recombinant Porcine Factor VIII (OBI-1) in the Treatment of Acquired Hemop
Acquired Hemophilia A