NCT07205523

High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)

High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT): A Prospective Real-World Cohort Study in the Qinghai-Tibet Plateau

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Yigeng Cao,MD,PhD · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT) study is the first prospective real-world cohort of hematologic diseases and transplantation in the Qinghai-Tibet Plateau. Patients undergoing hematopoietic stem cell transplantation (HSCT) at Qinghai University Affiliated Hospital, together with their donors, are systematically enrolled. The registry collects demographic, diagnostic, treatment, prognosis, and medical expense information, as well as biospecimens for future analyses. Historical data are incorporated, and prospective data collection is ongoing with long-term follow-up planned. The registry is designed as a sustainable research infrastructure to provide comprehensive data on disease incidence, treatment patterns, outcomes, and resource utilization in a high-altitude setting.

Detailed description

HALO-SCT is a prospective observational patient registry established at Qinghai University Affiliated Hospital, the first HSCT center in the Qinghai-Tibet Plateau. The registry aims to systematically capture patient and donor characteristics, transplant-related procedures, treatment outcomes, and long-term follow-up data in a high-altitude environment. Biospecimens, including peripheral blood and bone marrow samples, are collected at baseline and follow-up time points for future multi-omics studies. All clinical decisions follow routine practice; no experimental interventions are mandated by the protocol. The registry is intended as a long-term infrastructure project, with continuous data collection and integration into national and international collaborative research efforts.

Conditions

• Hematopoietic Stem Cell Transplantation (HSCT)
• Acute Myeloid Leukemia (AML)
• Leukemias, Acute Myeloid
• Myeloid Leukemias, Acute
• Hemophilia
• Myelodysplastic Syndrome
• MDS
• Lymphoma
• Leukemia
• Aplastic Anemia
• Bleeding Disorders
• Bone Marrow Transplantation
• Multiple Myeloma
• Myeloma, Multiple
• Immune Reconstitution

Timeline

• Start date: 2023-09-01
• Primary completion: 2060-12-31
• Completion: 2100-12-31
• First posted: 2025-10-03
• Last updated: 2025-10-03

Locations

1 site across 1 country: China