| Recruiting | Effect of Cannabis on E-Cigarette Use Behavior NCT06609109 | Johns Hopkins University | Phase 1 |
| Enrolling By Invitation | Nicotine and Cannabis Vape Labeling Experiment - Spring 2025 NCT06919276 | University of Southern California | N/A |
| Recruiting | Effects of E-cigarette Use on Health NCT06610838 | University of Wisconsin, Madison | — |
| Recruiting | The Avenues Study: Dual Use Cessation NCT06474299 | University of Wisconsin, Madison | Phase 4 |
| Completed | Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening NCT06472869 | Massachusetts General Hospital | N/A |
| Recruiting | Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use NCT06489249 | University of Iowa | EARLY_Phase 1 |
| Completed | Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC NCT05881304 | Massachusetts General Hospital | N/A |
| Unknown | Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan NCT06063421 | Strategic Health Research Limited | N/A |
| Unknown | Efficacy of Oral Hygiene Instructions on Proinflammatory Cytokines Among Cigarette Smokers and Individuals Vap NCT06177158 | University of Baghdad | N/A |
| Recruiting | Developing and Testing Health Warning Labels on the ENDS Device NCT04907136 | Florida International University | N/A |
| Completed | CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes NCT06087328 | Medical University of South Carolina | Phase 2 |
| Recruiting | Effects of Social Media Use on Young Adults' E-Cigarette Use NCT06142877 | University of Oklahoma | N/A |
| Completed | Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste) NCT05971823 | Virginia Commonwealth University | N/A |
| Completed | The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment NCT04522973 | Virginia Commonwealth University | N/A |
| Withdrawn | Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nico NCT04258852 | Yale University | N/A |
| Completed | Dual Use of ENDS and Combustible Cigarettes NCT05280535 | Brown University | N/A |
| Completed | Dual Use Approach Bias Training for Nicotine Addiction NCT05306158 | University of Houston | N/A |
| Completed | Nicotine Influence on the Retina Following the Use of Electronic Cigarette NCT05801419 | Christian Casanova | N/A |
| Recruiting | Effect of Menthol on ENDS Users' Addiction and Exposure NCT05338801 | Florida International University | N/A |
| Completed | Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems NCT05423340 | Roswell Park Cancer Institute | N/A |
| Completed | E-cigarettes for Harm Reduction in Adults With Asthma NCT05278065 | Brown University | N/A |
| Active Not Recruiting | Development of UP2UTobacco for High School Youth NCT05396911 | University of Virginia | N/A |
| Completed | Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures NCT05205382 | Florida International University | N/A |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2 NCT05958966 | University of Southern California | N/A |
| Active Not Recruiting | Methadone-Maintained Smokers Switching to E-Cigarettes NCT05206435 | Butler Hospital | Phase 4 |
| Completed | CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Del NCT05118139 | RAI Services Company | N/A |
| Completed | Cessation of Smoking Trial in the Emergency Department NCT04854616 | Norfolk and Norwich University Hospitals NHS Foundation Trust | N/A |
| Completed | Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury NCT05316727 | University of Pittsburgh | — |
| Recruiting | Vaping Adverse Lung and Heart Events Cohort NCT06291597 | Laval University | — |
| Completed | Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Cons NCT05134415 | Cheerain HK Limited | N/A |
| Completed | Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids NCT06602492 | Rochester Institute of Technology | EARLY_Phase 1 |
| Completed | The Impact of Vaping Ethanol in the Evaluation of Impairment NCT03826303 | Virginia Commonwealth University | N/A |
| Completed | E-cigarette Nicotine Study NCT04709471 | University of Vermont | Phase 2 |
| Completed | Assessing Electronic Cigarette Nicotine Flux NCT04378907 | Virginia Commonwealth University | N/A |
| Completed | Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study) NCT04332926 | Virginia Commonwealth University | N/A |
| Completed | Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by Smokers NCT04640285 | Cheerain HK Limited | N/A |
| Completed | Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery Sy NCT04708106 | Cheerain HK Limited | N/A |
| Completed | Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Co NCT04620616 | Cheerain HK Limited | N/A |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2 NCT05958992 | University of Southern California | N/A |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1 NCT05958979 | University of Southern California | N/A |
| Completed | PACE Vape Messaging Study NCT04450537 | University of Vermont | N/A |
| Completed | Factors That Impact the Relationship Between Pulmonary Status and Susceptibility to Electronic Cigarette Use NCT04151784 | University of Alabama at Birmingham | — |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1 NCT04399031 | University of Southern California | N/A |
| Completed | Study to Characterize Puffing Topography With Use of JUUL Electronic Nicotine Delivery Systems (ENDS) in Adult NCT04088175 | Juul Labs, Inc. | N/A |
| Completed | Evaluating Selected Constituents in the Exhaled Breath Samples NCT04143256 | Juul Labs, Inc. | N/A |
| Completed | Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems NCT04123041 | Juul Labs, Inc. | N/A |
| Completed | Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS NCT04107779 | Juul Labs, Inc. | N/A |
| Completed | Preventing Relapse to Smoking Among Prisoners After Release NCT04271371 | University of Nottingham | — |
| Terminated | Effects of Nicotine Salt Aerosol on Cigarette Smokers NCT03974152 | Eastern Virginia Medical School | N/A |
| Completed | Assessing the Effect of Flavor on ENDS Users' Experiences and Exposures NCT04192032 | Florida International University | N/A |
| Completed | Vaporized Nicotine and Autonomic Control NCT04613609 | Michigan Technological University | EARLY_Phase 1 |
| Completed | Acute Health Effects of Passive Vape Among COPD Patients NCT04316234 | University of Aarhus | N/A |
| Completed | Factors That Impact the Relationship Between Pulmonary Status and Actual Electronic Cigarette Use NCT04135404 | University of Alabama at Birmingham | — |