NCT04613609

Vaporized Nicotine and Autonomic Control

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Michigan Technological University · Academic / Other
• Sex: All
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

E-cigarettes are marketed as an alternative to smoking for those who want to decrease the health risks of tobacco. Tobacco cigarettes increase heart rate (HR) and arterial pressure, while reducing muscle sympathetic nerve activity (MSNA) through sympathetic baroreflex inhibition. The acute effects of e-cigarettes on arterial pressure and MSNA have not been reported: our purpose was to clarify this issue. Using a randomized crossover design, participants inhaled on a JUUL containing nicotine (59 mg/ml) and a similar placebo e-cigarette (0 mg/ml).

Conditions

• Electronic Cigarette Use

Interventions

Type	Name	Description
DEVICE	Electronic Cigarette containing nicotine	Non-smokers used an electronic cigarette containing nicotine
DEVICE	Electronic Cigarette without nicotine	Non-smokers used an electronic cigarette without nicotine

Timeline

• Start date: 2018-04-01
• Primary completion: 2019-07-01
• Completion: 2019-07-01
• First posted: 2020-11-03
• Last updated: 2020-11-03

Locations

1 site across 1 country: United States