NCT03974152

Effects of Nicotine Salt Aerosol on Cigarette Smokers

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Eastern Virginia Medical School · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This grant compares the effects of cigarette smoking, protonated nicotine ("salt") aerosol through an Electronic Nicotine Delivery System (ENDS), and unprotonated nicotine aerosol through an ENDS on nicotine delivery, nicotine craving, and other outcomes in cigarette smokers.

Detailed description

The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use a nicotine "salt" (protonated) aerosol, relative to an unprotonated aerosol or their own brand of cigarettes.

Conditions

• Electronic Cigarette Use

Interventions

Type	Name	Description
OTHER	Subox Mini C with Avail 18 mg nicotine salt (protonated)	Participants will be instructed to take one puff of the Subox Mini C with Avail 18 mg nicotine salt (protonated) liquid every 30 seconds for 5 minutes followed by a 2nd blood draw. Next, participants will be given 90 minutes to use the product ad lib, i.e., as much as desired.
OTHER	Subox Mini C with Avail 18 mg nicotine (unprotonated)	Participants will be instructed to take one puff of the Subox Mini C with Avail 18 mg nicotine (unprotonated) liquid every 30 seconds for 5 minutes followed by a 2nd blood draw. Next, participants will be given 90 minutes to use the product ad lib, i.e., as much as desired.
OTHER	Own brand cigarette	Participants will be instructed to take one puff of a cigarette matching their typical brand every 30 seconds for 5 minutes followed by a 2nd blood draw. Next, participants will be given 90 minutes to use the product ad lib, i.e., as much as desired.

Timeline

• Start date: 2019-06-10
• Primary completion: 2020-03-05
• Completion: 2020-03-05
• First posted: 2019-06-04
• Last updated: 2024-03-26
• Results posted: 2024-02-02

Locations

1 site across 1 country: United States