NCT05971823

Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users. The investigators will compare abuse liability indices between three FDA-authorized ECIG products that vary in nicotine flux (but are all tobacco flavor) and own brand cigarettes. The investigators will also test the influence of ECIG flavor availability (tobacco vs. menthol) within three ECIG product classes.

Conditions

• Electronic Cigarette Use

Interventions

Type	Name	Description
OTHER	Tobacco product administration and assessment	Subjective measures 1 is followed by product sampling that includes 5 self-directed ECIG/own brand cigarette puffs over 10 minutes. After sampling is complete participants complete subjective measures 2. Ten minutes after their sampling has been completed, they complete subjective measures 3 and the behavioral economic task(s). These activities are preceded and followed by cardiovascular response assessment.

Timeline

• Start date: 2023-07-31
• Primary completion: 2024-07-26
• Completion: 2024-07-26
• First posted: 2023-08-02
• Last updated: 2026-04-06
• Results posted: 2026-04-06

Locations

1 site across 1 country: United States