NCT04332926

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study aims to better understand how e-cigarettes (ECIG) nicotine flux impacts several behavioral economic measures of abuse liability.

Conditions

• Electronic Cigarette Use

Interventions

Type	Name	Description
OTHER	Tobacco product administration and assessment, own brand cigarettes	4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment
OTHER	Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine	4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment
OTHER	Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine	4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment
OTHER	Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine	4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment
OTHER	Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine	4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment

Timeline

• Start date: 2021-01-05
• Primary completion: 2023-06-01
• Completion: 2023-09-08
• First posted: 2020-04-03
• Last updated: 2025-02-13
• Results posted: 2025-02-13

Locations

1 site across 1 country: United States