Dry Eye Syndromes

271 registered clinical trials studyying Dry Eye Syndromes — 20 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Lacrima VR for Dry Eye Disease and Meibomian Gland Dysfunction NCT07415330	Demaod Ltd	N/A
Not Yet Recruiting	Blink Reminders and Meibomian Gland Loss in Digital Screen Users NCT07430137	Asociación para Evitar la Ceguera en México	N/A
Not Yet Recruiting	Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the NCT06379685	Laboratorios Sophia S.A de C.V.	Phase 1
Not Yet Recruiting	Switching From Xiidra to TRYPTYR NCT07267481	Southern College of Optometry	Phase 4
Not Yet Recruiting	Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye NCT05121493	University of Rochester	N/A
Not Yet Recruiting	Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Sever NCT06903611	Cambium Bio Limited	Phase 3
Recruiting	Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substa NCT07412860	FB Vision S.p.A	N/A
Active Not Recruiting	The Impact of Hypothyroidism on Tear Production and Dry Eye Symptoms: Implications for Optometric Care NCT06913465	Superior University	—
Active Not Recruiting	Comparison Of Blue Light Filter Feature and Blue Blocking Lenses in Digital Device Users With Dry Eye Patients NCT06913504	Superior University	N/A
Recruiting	Efficacy of Platelet-Rich Plasma Injection in Dry Eye Syndrome NCT06831253	Centre Hospitalier Universitaire de Nice	N/A
Completed	Laser Acupuncture for Dry Eye Disease Due to Visual Display Terminal Use NCT06688630	Indonesia University	N/A
Recruiting	Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD NCT06220474	The University of Hong Kong	N/A
Recruiting	Difference of Tear Ferning Between Women with and Without Menopausal. NCT06848829	Chung Shan Medical University	N/A
Recruiting	Protecting the Eyes of Gamers With Lubricating Eyedrops NCT06163989	Aston University	N/A
Not Yet Recruiting	iTear Single-center, Open-label, Single-arm Study NCT06525961	The University of Hong Kong	Phase 4
Recruiting	Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye NCT06543667	Iran University of Medical Sciences	Phase 1
Completed	Traditional Chinese Medicine Ultrasonic Atomization Treatment for Dry Eye Disease NCT06089317	Chinese University of Hong Kong	N/A
Completed	Preoperative iLux on Cataract Surgery Derived Dry Eye Disease Due to Meibomian Gland Dysfunction NCT06483750	George Washington University	N/A
Completed	To Evaluate the Efficacy and Safety of HUC3-053 in Patients With Dry Eye Syndrome NCT06388070	Huons Co., Ltd.	Phase 3
Not Yet Recruiting	Assessment of Tear Production, Corneal Staining, and Comfort Level Wearing Different Types of Contact Lenses NCT06351410	National University of Malaysia	N/A
Recruiting	Photobiomodulation With REd vs BluE Light (REBEL) NCT06371300	Aston University	N/A
Completed	Tear Ferning Test for Dry Eye Diagnosis NCT06364943	Chung Shan Medical University	N/A
Unknown	Evaluation of Dry Eye Disease's Signs in Patients Who Were Administered Intravitreal Anti-VEGF Injections NCT06317922	Francesco Bandello	N/A
Unknown	Dual-Polymer Hydroxypropyl Guar-and Hyaluronic Acid Lubricants in Rheumatoid Arthritis NCT06209879	Chang Gung Memorial Hospital	Phase 4
Unknown	BroadBand Light for the Treatment of Dry Eye Disease NCT06174064	University of Southern California	N/A
Completed	Efficacy of a New Nanoemulsion Artificial Tear Targeting Dry Eye Disease NCT06188260	The Hong Kong Polytechnic University	Phase 2
Completed	Lubricating Effectiveness of Carragelose Eye Drops in Patients Affected by Mild to Moderate Dry Eye NCT06262100	Marinomed Biotech AG	N/A
Active Not Recruiting	A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocul NCT06404541	Kasr El Aini Hospital	Phase 4
Recruiting	Efficacy and Safety of AJU-S56 5% in Dry Eye Syndrome Patients NCT06291194	AJU Pharm Co., Ltd.	Phase 3
Completed	Mechanisms of Light-based Therapies for Dry Eye Disease NCT06004895	Aston University	N/A
Terminated	A Study to Assess the Safety and Efficacy of IC265 Ophthalmic Solution for Dry Eye in Adult Participants NCT05992922	Iacta Pharmaceuticals	Phase 2
Completed	Preventive TREatment of Dry Eye in Patients Receiving Repeated Intravitreal Injections for Age-related Macular NCT06174181	Direction Centrale du Service de Santé des Armées	N/A
Active Not Recruiting	Therapeutic Effect of Stem Cell Eye Drops on Dry Eye Disease NCT05784519	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	EARLY_Phase 1
Unknown	The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and I NCT05990712	Uptown Eye Specialists	Phase 4
Completed	Feasibility of Dynamic Muscle Stimulation + Radiofrequency for Improving Blink Quality in Subjects with Dry Ey NCT05945069	Lumenis Be Ltd.	N/A
Completed	Comparing Efficacy and Safety of TJO-083 in Dry Eye Diseases Patients NCT06427031	Taejoon Pharmaceutical Co., Ltd.	Phase 3
Recruiting	Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome NCT06406933	Chang Gung Memorial Hospital	—
Completed	Efficacy and Safety Evaluation of Tavilermide Ophthalmic Solution for the Treatment of Dry Eye NCT05848128	Mimetogen Pharmaceuticals USA, Inc.	Phase 3
Unknown	Evaluation of Optical System in the Treatment of - Dry Eye Disease NCT05741398	Demaod Ltd	N/A
Completed	Intra-Nasal Mechanical Stimulation (INMEST) As a Treatment Method for the Relief of Symptoms of Dry Eye NCT05887336	Abilion Medical Systems AB	N/A
Completed	OTX-DED for the Short-term Treatment of the Symptoms of Dry Eye Disease (DED) NCT05814757	Ocular Therapeutix, Inc.	Phase 2
Unknown	Omega-3 Fatty Acid Supplementation and Tear Film Quality in Celiac Patients NCT05825976	Josip Juraj Strossmayer University of Osijek	N/A
Completed	Investigation of Preservative-Free Ophthalmic Solution in Ocular Dryness NCT05778942	SIFI SpA	—
Completed	A Feasibility Study to Evaluate the Tolerability of Oph1 Compared to Restasis in Healthy Volunteers NCT05184517	OphRx Ltd.	EARLY_Phase 1
Completed	Clinical Trial to Evaluate the Safety and Efficacy of SCAI-001 Compared to Restasis NCT05733624	SCAI Therapeutics	Phase 2
Suspended	Prospective Study to Validate the Imaging Biomarker for NCP (R33) NCT05653921	Tufts Medical Center	—
Completed	Lifitegrast Eye Drops in Healthy Subjects：Phase I Study NCT07040826	Qilu Pharmaceutical Co., Ltd.	Phase 1
Completed	Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction NCT04425551	Naval Hospital, Athens	N/A
Unknown	Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed With Dry Eye Disease in NCT05598437	Roweis adel youssef	—
Completed	to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysf NCT05162261	Novoxel Ltd.	N/A
Completed	Efficacy and Safety Safety of Nutritears® in Adults With Dry Eye Syndrome NCT05481450	Applied Science & Performance Institute	N/A
Active Not Recruiting	Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals NCT05763940	Western University of Health Sciences	N/A
Unknown	Effect of Exercises on Computer Vision Syndrome NCT05414799	Shifa Tameer-e-Millat University	N/A
Completed	Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome NCT05292755	University of Florida	Phase 4
Completed	A Clinical Trial to Evaluate the Safety and Efficacy of Rreproxalap in Adults With Dry Eye Disease NCT05424549	Aldeyra Therapeutics, Inc.	Phase 2
Unknown	A Usability Study of External Neuromodulation With iTEAR100 Generation 2 NCT05304650	Olympic Ophthalmics, Inc.	Phase 4
Completed	A Phase 3, Multi-Center Study Evaluating PL9643 in Patients with Dry Eye NCT05201170	Palatin Technologies, Inc	Phase 3
Completed	Efficacy and Safety of AJU-S56 in Dry Eye Syndrome Patients NCT06337981	AJU Pharm Co., Ltd.	Phase 2
Completed	Optimization of the Ocular Surface Prior to Cataract Surgery Using PROKERA NCT05148507	Jeff Wongskhaluang	N/A
Unknown	Effect of Topical Antioxidants in Dry Eye Disease and Diabetic Retinopathy NCT05429229	Adolfo Daniel Rodriguez-Carrizalez	Phase 2
Completed	Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Serum Vitamin D Level NCT05425914	University of Faisalabad	Phase 3
Completed	Evaluate the Safety and Effectiveness of The Tixel Fractional System in the Treatment of Meibomian Gland Disfu NCT04889950	Novoxel Ltd.	N/A
Unknown	The Proportion of Patients Diagnosed With Dry Eye by the Asia Dry Eye Society (ADES) Criteria in Taiwan (DECS- NCT05096546	Far Eastern Memorial Hospital	—
Unknown	Comparing Efficacy and Safety of TJO-083 in Dry Eye Disease Patients NCT05346783	Taejoon Pharmaceutical Co., Ltd.	Phase 1 / Phase 2
Completed	3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconj NCT04701086	Santen SAS	N/A
Completed	Computer Screen Properties Study NCT05042960	NYU Langone Health	N/A
Completed	CEQUA for Sjogren's Syndrome Dry Eye NCT04835623	Center for Ophthalmic and Vision Research, LLC	Phase 4
Active Not Recruiting	3 Month Study of Alocross Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjuncti NCT04685109	Santen SAS	N/A
Unknown	Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS Wit NCT04863742	Sight Medical Doctors PLLC	Phase 4
Unknown	Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of GLH8NDE in Patients With Dry Eye Disease NCT04679883	GL Pharm Tech Corporation	Phase 2
Unknown	Effect of Traditional Chinese Medicine on Basic Tear Secretion and Tear Cytokines in Patients With Dry Eye Dis NCT04785261	China Medical University Hospital	Phase 2
Completed	Treatment Regimens in Meibomian Gland Dysfunction NCT05594745	Tauber Eye Center	Phase 4
Withdrawn	Effect of Lifitegrast 5% on Tear Film Markers NCT03952481	Weill Medical College of Cornell University	Phase 4
Unknown	Quantum Molecular Resonance Effects on Patients With Dry Eye Disease NCT05469932	Assaf-Harofeh Medical Center	N/A
Completed	Management of Dry Eye Disease After Cataract Surgery With Topical Hyaluronic Acid and Gingko Biloba NCT05002036	University of Milan	Phase 4
Unknown	The Effect of 3% Diquafosol Ophthalmic Solution on Visual Display Terminal-associated Dry Eye NCT04668118	Peking University Third Hospital	Phase 4
Unknown	Mask-associated Dry Eye Symptoms in China NCT04744805	Tianjin Eye Hospital	—
Completed	Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye NCT04493658	Johns Hopkins University	—
Unknown	Platelet Rich Plasma Eye Drops for Treatment of Ocular Surface Disease NCT04608084	University Health Network, Toronto	Phase 4
Completed	Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fittin NCT04649177	Boston Sight	N/A
Completed	The TRANQUILITY Trial: Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease NCT04674358	Aldeyra Therapeutics, Inc.	Phase 2 / Phase 3
Completed	Topical Naloxone to Diagnose Ocular Pain NCT04454281	Seema Capoor	Phase 1
Completed	Effect of Ciclosporin Eyedrops on Sjögren Syndrome NCT04597762	Hospital Hietzing	N/A
Completed	The Effect of Cyclosporin Before Cataract Surgery NCT04426240	Samsung Medical Center	Phase 4
Unknown	Metabolomic Profile in Dry Eye Syndrome Patients. NCT05433428	Ifocus Oyeklinikk	Phase 4
Terminated	Xiidra vs. Xiidra + Dextenza Treatment for Dry Eye Disease NCT04413253	Eye Surgeons of Indiana	Phase 4
Completed	Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease NCT04413279	Eye Surgeons of Indiana	Phase 4
Unknown	CDSS of Traditional Chinese Medicine Intervention for Dry Eye Syndrome NCT04806256	Peking University Third Hospital	N/A
Unknown	Clinical Investigation to Assess the Efficacy and the Safety of VisuXL® Gel Administered in Patients Affected NCT04485533	VISUfarma SpA	N/A
Completed	Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients NCT04342988	Research Insight LLC	Phase 4
Completed	Clinical Effect of MiboFlo in Dry Eye Patients NCT04310969	Beijing Tongren Hospital	N/A
Withdrawn	Clinical Efficacy of Intense Pulsed Light(IPL) Procedure in Dry Eye Patient NCT04391907	Samsung Medical Center	N/A
Completed	[KSR-001-P02] Phase 2b/3 Study, Evaluate the Efficacy and Safety of KSR-001 in Patients With Dry Eye Syndrome NCT05017844	Kukje Pharma	Phase 2 / Phase 3
Completed	Efficacy and Safety of Ikervis Under Controlled Environmental Conditions Environment NCT04492878	Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA	Phase 4
Completed	Differences in Dry Eye Symptoms Related to Geographic Location in Spain and Impact of Artificial Tears Use NCT06499753	University of Valladolid	—
Terminated	Prospective Study To Assess The Safety And Effectiveness Of Tixel Treatment On Dry Eye Symptoms In Asian Patie NCT04260893	Novoxel Ltd.	N/A
Unknown	Umbilical Cord Serum Versus Conventional Eyedrops NCT04217785	National University of Malaysia	Phase 1 / Phase 2
Completed	ACCURATE Study for Subjects With Dry Eyes NCT04237012	The Eye Centers of Racine and Kenosha	Phase 4
Completed	Evaluating HA 0.15% Compared With Cyclosporine 0.05%, and Efficacy of Combination Therapy in Dry Eye Disease P NCT04127851	Taejoon Pharmaceutical Co., Ltd.	Phase 4
Terminated	Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease NCT04143841	Epitech Mag Ltd.	N/A
Completed	Intense Pulsed Light in Meibomian Gland Dysfunctions NCT04147962	Centre Hospitalier Universitaire de Saint Etienne	—
Completed	A Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of GLH8NDE After Sin NCT04104997	GL Pharm Tech Corporation	Phase 1
Completed	An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on th NCT04280653	Mati Therapeutics Inc.	N/A
Completed	Effect of Intraoperative Dexamethasone on Post-op Dry Eye NCT04184999	SR Cornea Consultants	Phase 4
Completed	Assessing the Impact of Tixel Treatment of Periorbital Wrinkles on Dry Eye Symptoms and Signs NCT04730336	Aston University	N/A
Completed	A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi® NCT03803748	SIFI SpA	N/A
Unknown	The Effect of Combination of Vitamin A, Vitamin E, Sodium Hyaluronate 0.15% Eye Drop Compared With Sodium Hyal NCT04000789	Dr Cipto Mangunkusumo General Hospital	N/A
Terminated	Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease NCT03827564	Allergan	N/A
Completed	Meibomian Gland Dysfunction Management With ZEST Protocol NCT03968731	University of the Incarnate Word	N/A
Completed	The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal Injection NCT03945071	University of Oklahoma	N/A
Completed	Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients NCT04063644	OPKO Health, Inc.	N/A
Completed	Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3 NCT03937882	ReGenTree, LLC	Phase 3
Completed	HU007 Eye Drops in Patients With Dry Eye Syndrome NCT04384991	Huons Co., Ltd.	Phase 3
Completed	Efficacy of T2259 in DED NCT03874429	Laboratoires Thea	N/A
Completed	Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects NCT05219461	Daewoong Bio Inc.	Phase 1
Completed	Amniotic Membrane Treatment for Hyposecretory Dry Eye NCT05598242	Hospital Nacional Profesor Alejandro Posadas	Phase 3
Completed	Corneal Epithelial Stem Cells and Dry Eye Disease NCT03302273	Sloan W. Rush, MD	N/A
Completed	Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome NCT03821415	Redwood Pharma AB	Phase 2
Completed	Pilot Study of TearCare System - Long-Term Extension NCT03804502	Sight Sciences, Inc.	N/A
Completed	Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops NCT03706443	Ohio State University	N/A
Completed	[KSR-001-P01]Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristic of KSR-001 NCT05017870	Kukje Pharma	Phase 1
Completed	TrueTear in Sjogren's Disease Patients NCT03719885	University of Pennsylvania	N/A
Completed	Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye Disease NCT04165785	First Affiliated Hospital of Harbin Medical University	N/A
Completed	Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel NCT03697876	Laboratorios Sophia S.A de C.V.	Phase 1
Completed	A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease NCT03527212	Senju Pharmaceutical Co., Ltd.	Phase 3
Completed	Effect of ADDE on Tear Interferometry NCT05456061	Yonsei University	N/A
Terminated	Management of Signs and Symptoms Associated With Dry Eye Disease NCT04015219	BioTissue Holdings, Inc	N/A
Completed	Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction NCT03518398	Chulalongkorn University	Phase 3
Terminated	Randomized Study of the Safety and Effectiveness of the TearCare System for the Signs and Symptoms of Dry Eye NCT03502447	Sight Sciences, Inc.	N/A
Completed	Evaluation of an Updated Version of the Program "BlinkBlink" for Alleviation of Dry Eye Symptoms Induced by Co NCT04637516	University of Applied Sciences and Arts Northwestern Switzerland	N/A
Unknown	Fingerprick Autologous Blood (FAB) in Severe Dry Eye Disease (DED) NCT03395431	Bedford Hospital NHS Trust	N/A
Completed	Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye NCT03417505	Tangible Science	N/A
Unknown	Wumeiwan Jiawei Fang Use in Patients With Blepharospasm NCT05618470	China Academy of Chinese Medical Sciences	Phase 2 / Phase 3
Completed	Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland Dysfunction NCT03162497	Medical University of Vienna	Phase 4
Unknown	Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders NCT03731624	Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation	—
Recruiting	Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALT NCT03358979	Fondation Ophtalmologique Adolphe de Rothschild	—
Completed	Clinical Study to Investigate the Efficacy and Safety of SJP002 Ophthalmic Solution in Patients With Dry Eye S NCT03723811	Samjin Pharmaceutical Co., Ltd.	Phase 2
Completed	Clinical Trial to Evaluate the Symptoms in Symptomatic Contact Lens Wearers Following Application of Intranasa NCT03325673	Allergan	N/A
Completed	Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye NCT03012698	Epitech Mag Ltd.	N/A
Completed	Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction NCT03318874	Oslo University Hospital	Phase 4
Terminated	Clinical Study to Evaluate Tear Characteristics Following Acute TrueTear™ Use NCT03274999	Allergan	N/A
Unknown	LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients NCT03140111	NHS Greater Glasgow and Clyde	N/A
Completed	Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye NCT03617315	University of Seville	N/A
Recruiting	Assessment of TFT by OCT in Healthy Subjects and Subjects With DES NCT02585414	Medical University of Vienna	—
Withdrawn	Punctal Plugs and Iodine Related Discomfort NCT03396809	University of New Mexico	N/A
Completed	Safety and Efficacy of TrueTear™ for the Treatment of Meibomian Gland Disease NCT03226769	Allergan	N/A
Completed	Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Su NCT03524157	Laboratorios Sophia S.A de C.V.	Phase 1
Unknown	Ocular Micro-vascular Research Base on Functional Slip Lamp Biomicroscopy NCT03747614	Zhongshan Ophthalmic Center, Sun Yat-sen University	Phase 4
Completed	A Randomized, Double Masked, Clinical Study of Subjects With Dry Eye Syndrome NCT03162783	Aldeyra Therapeutics, Inc.	Phase 2
Terminated	Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life NCT03296111	Fondation Ophtalmologique Adolphe de Rothschild	—
Completed	Effect of Lipid Based Eye Drops on Tear Film Lipid Layer Thickness NCT03399292	Medical University of Vienna	—
Completed	Dry Eye Symptom Relief Assessment With Use of TrueTear in a Controlled Adverse Environment NCT03097614	Oculeve, Inc.	N/A
Completed	Tear Lipid Layer Thickness With Emollient Eye Drops NCT03380624	Ohio State University	Phase 4
Completed	Lamelleye vs Comparator for the Treatment of Dry Eye Disease NCT03052140	Glasgow Caledonian University	N/A
Completed	Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dr NCT03161080	Medical University of Vienna	N/A
Completed	Comparison Between Rebamipide 2% Versus Autologous Serum NCT03608761	Hospital Nacional Profesor Alejandro Posadas	Phase 4
Terminated	Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye NCT02965846	Allergan	Phase 3
Completed	Topical Omega-3 Fatty Acids (REMOGEN® OMEGA) in the Treatment of Dry Eye NCT02908282	TRB Chemedica AG	N/A
Completed	Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation NCT02910713	Allergan	N/A
Terminated	Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye NCT02815293	Allergan	Phase 3
Completed	A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye NCT02871440	The University of New South Wales	Phase 3
Completed	Tear Production by Nasal Neurostimulation Compared to Active Control NCT02970799	Oculeve, Inc.	N/A
Unknown	Assessment of the Efficacy of Ocular Dipyridamole in the Treatment of Dry Eye Symptomology in Subjects With Pt NCT02782260	Ariel University	Phase 2
Completed	Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease NCT02819284	Kala Pharmaceuticals, Inc.	Phase 3
Completed	Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease NCT02813265	Kala Pharmaceuticals, Inc.	Phase 3
Unknown	Effect of Nursing Care on Prevention of Dry Eye NCT02767258	Diego Dias de Araújo	N/A
Completed	Effects of a Moisturizing Product on Dry Eye and Skin NCT02683382	Petra Larmo	N/A
Completed	Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and NCT02986750	Medical University of Vienna	Phase 4
Completed	Difference in the Frequency of Use of Lachrymal Substitutes in Patients With Moderate to Severe Dry Eye Syndro NCT02980913	Medical University of Vienna	N/A
Completed	Added Benefits of Lachrymal Substitute Gel During the Night in Patients With Moderate to Severe Dry Eye Syndro NCT02585648	Medical University of Vienna	N/A
Completed	A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease. NCT02553772	Allergan	Phase 3
Completed	CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED) NCT02617667	Novaliq GmbH	Phase 2
Completed	Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye NCT03183089	The Mentholatum Company	Phase 4
Completed	Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD NCT02621593	Lumenis Be Ltd.	N/A
Unknown	0.3% Sodium Hyaluronate in the Treatment of Dry Eye of Diabetic Patients NCT02595606	Sun Yat-sen University	Phase 4
Completed	Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator NCT02526290	Oculeve, Inc.	N/A
Unknown	Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients NCT02533154	Medical University of Vienna	Phase 4
Completed	Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Usi NCT02554981	Allergan	Phase 4
Completed	Safety, Efficacy, Tolerability and Pharmacokinetics of AGN-223575 Ophthalmic Suspension in Patients With Dry E NCT02435914	Allergan	Phase 2
Completed	Safety, Tolerability and Systemic Pharmacokinetics of AGN-232411 in Healthy Participants and Participants With NCT02420730	Allergan	Phase 1
Completed	Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation NCT02385292	Oculeve, Inc.	N/A
Completed	Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Synd NCT02585453	Medical University of Vienna	Phase 4
Completed	The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease NCT02802150	Chonbuk National University Hospital	N/A
Completed	NovaTears® Eye Drops Observational Study NT-003 NCT02356328	Novaliq GmbH	—
Completed	NovaTears® Eye Drops Observational Study NT-002 NCT02356341	Novaliq GmbH	—
Completed	A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Mod NCT02455050	Allergan	Phase 3
Completed	Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With NCT02313454	Allergan	N/A
Completed	A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease NCT02280473	Allergan	Phase 3
Completed	Interest of Eye Movement Measurements in the Comprehension of Dry Eyes Symptoms NCT02851654	Fondation Ophtalmologique Adolphe de Rothschild	—
Completed	A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye. NCT02205840	Seikagaku Corporation	Phase 2 / Phase 3
Completed	The Effect of Tear Supplements on Contact Lens Comfort NCT02956083	University of the Incarnate Word	N/A
Completed	Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease NCT02188160	Kala Pharmaceuticals, Inc.	Phase 2
Completed	A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye NCT02117687	Allergan	Phase 4
Terminated	Phase 2 Study of a New Ophthalmic Formulation of Cyclosporine (Restasis® X) in Patients With Dry Eye Disease NCT02013791	Allergan	Phase 2
Completed	Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy NCT02121847	Allergan	Phase 4
Unknown	Estrogen and the Outer Eye in Women During Fertility Treatment NCT02072122	Meir Medical Center	—
Terminated	Effects of Sustained Reading on the Ocular Surface NCT02031172	University of Rochester	—
Completed	Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery NCT02608489	Soonchunhyang University Hospital	N/A
Completed	Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes NCT02461719	Taejoon Pharmaceutical Co., Ltd.	Phase 3
Completed	A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN) NCT02014922	University of Waterloo	Phase 4
Completed	Study of Tisporin Eye Drops Group and Restasis Eye Drops Group After Treatment, Each Treatment Group Compariso NCT02229955	Hanlim Pharm. Co., Ltd.	Phase 3
Completed	A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye NCT01960010	Mimetogen Pharmaceuticals USA, Inc.	Phase 3
Completed	Ocular Surface Microbiome NCT02298881	University of Washington	—
Completed	A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal NCT01882413	Allergan	—
Completed	An Observational Study of Dry Eye Prior to Laser-Assisted in Situ Keratomileusis (LASIK) Therapy NCT01854905	Allergan	—
Completed	Paralysis of the Orbicularis Muscle of the Eye in the Treatment for Dry Eye NCT02403219	Instituto de Oftalmología Fundación Conde de Valenciana	Phase 1
Completed	Impairment of Reading Ability in Dry Eye Patients NCT01826812	Johns Hopkins University	—
Completed	A Pilot Study on the Use of a Sensory Panel to Assess Comfort Between Three Different Contact Lenses NCT01840787	University of Waterloo	N/A
Completed	A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Synd NCT02011776	Santen Pharmaceutical(China) Co.,LTD	—
Completed	Efficacy and Safety Study of Haporine-S for Treatment of Moderate to Severe Dry Eye Syndromes NCT01804361	DH Bio Co., Ltd.	Phase 3
Completed	Prevalence of Dry Eye Disease in Patients Diagnosed With Rheumatoid Arthritis NCT02252744	Western University of Health Sciences	—
Completed	An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease NCT01711424	Allergan	—
Completed	Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group NCT01768312	Hanlim Pharm. Co., Ltd.	Phase 3
Completed	Non Interventional Study to Evaluate the Efficacy and Tolerability of Ectoin Containing Ophthalmic Solution NCT01684852	Bitop AG	—
Completed	Comparison of the Efficacy and Safety of T2750 and Vismed® in the Treatment of Moderate to Severe Dry Eye Synd NCT01568593	Laboratoires Thea	Phase 3
Completed	A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye NCT01558999	Seikagaku Corporation	Phase 2
Completed	Safety Study of OPC-12759 Ophthalmic Solution NCT01471093	Otsuka Pharmaceutical Co., Ltd.	Phase 1
Completed	Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease NCT01459588	Allergan	Phase 3
Withdrawn	Treatment of Dry Eye With Supplements NCT01364311	Medical University of Vienna	N/A
Completed	A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms NCT02028754	Allergan	Phase 4
Completed	Repeatability and Agreement of Anterior Segment Optical Coherence Tomography (AS-OCT) and Thermography NCT01479790	Singapore National Eye Centre	N/A
Completed	Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease NCT01294384	Allergan	Phase 3
Completed	Safety Evaluation of a New Preservative in a Lubricating Eye Drop NCT01434277	Johnson & Johnson Consumer and Personal Products Worldwide	N/A
Unknown	Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms NCT01382810	Innovative Medical	Phase 4
Completed	The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients NCT01280110	University of Campinas, Brazil	Phase 4
Completed	Local Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers NCT01278784	Medical University of Vienna	Phase 1
Completed	Study of Two Formulations of Cyclosporine Ophthalmic Emulsion in Healthy Volunteers and in Patients With Dry E NCT01319773	Allergan	Phase 1
Completed	Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction NCT01202747	TearScience, Inc.	Phase 2 / Phase 3
Completed	Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers NCT01015209	Medical University of Vienna	Phase 1
Completed	A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease NCT01135511	Pfizer	Phase 2
Completed	TearLab Refractive Surgery Dry Eye Study NCT01176045	TearLab Corporation	—
Completed	Dry Eye Assessment and Management: Feasibility Study NCT01102257	Asbell, Penny, M.D.	Phase 2 / Phase 3
Completed	Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye NCT01027013	Kubota Vision Inc.	Phase 2
Completed	Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye NCT00987727	Allergan	Phase 4
Completed	Acupuncture for Dry Eye Syndrome NCT00969280	Korea Institute of Oriental Medicine	Phase 3
Completed	Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Si NCT00938704	Allergan	Phase 4
Completed	Confirmatory Study of OPC-12759 Ophthalmic Suspension NCT00885079	Otsuka Pharmaceutical Co., Ltd.	Phase 3
Completed	The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry NCT01268735	University of Zagreb	Phase 4
Completed	Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye NCT00832130	TearScience, Inc.	N/A
Completed	Long Term Administration Study of OPC-12759 Ophthalmic Suspension NCT00818324	Otsuka Pharmaceutical Co., Ltd.	Phase 3
Completed	A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects With Dry E NCT00784719	Pfizer	Phase 1 / Phase 2
Completed	Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome NCT00788229	Dhp Korea Co., Ltd.	Phase 2
Completed	Comparison of Evaporimetry With the Established Methods of Tear Film Measurement NCT01496482	University of Zagreb	—
Completed	Effects of Sea Buckthorn Oil on Dry Eye NCT00739713	University of Turku	N/A
Completed	Efficacy and Acceptability of Two Lubricant Eye Drops NCT00756678	Allergan	Phase 4
Completed	Validation of TearLab Osmometer - Human Factor Usability Report NCT00731484	TearLab Corporation	—
Completed	Diagnostic Evaluation of the Tear Film NCT00761917	TearScience, Inc.	—
Completed	Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refrac NCT00620893	Bp Consulting, Inc	Phase 4
Completed	Safety and Efficacy Study of Cyclosporine Ophthalmic Emulsion in Post-LASIK Patients NCT00611403	Allergan	Phase 2
Terminated	Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Di NCT01072526	University of Missouri-Columbia	Phase 2
Completed	Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms NCT00761202	Allergan	Phase 4
Completed	Refractive Surgery and Optive Compatibility Study NCT00469157	Innovative Medical	Phase 4
Completed	Late Phase 2 Study of OPC-12759 Ophthalmic Suspension NCT00475319	Otsuka Pharmaceutical Co., Ltd.	Phase 2
Recruiting	Clinical Applications of Advanced Ophthalmic Imaging NCT03135327	University of Miami	N/A
Unknown	Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus NCT00797030	Universidade Federal do Rio de Janeiro	Phase 4
Completed	Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome NCT00370747	Bausch & Lomb Incorporated	Phase 2
Completed	Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefracti NCT00349440	Innovative Medical	Phase 4
Completed	The Effect of Punctal Plugs on Tear Volume and Osmolality NCT00372034	The University of New South Wales	N/A
Completed	Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome NCT00198536	Bausch & Lomb Incorporated	Phase 2 / Phase 3
Completed	Dose-response Study of OPC-12759 Ophthalmic Suspension NCT00234078	Otsuka Pharmaceutical Co., Ltd.	Phase 2
Completed	Efficacy of T1675 Versus Placebo in Patients With Bilateral Treated Moderate Dry Eye Syndrome NCT00357201	Laboratoires Thea	Phase 2
Completed	Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITE™) Versus 0.5% NCT00386646	Chulalongkorn University	Phase 4
Completed	A Parallel Group Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes NCT01692145	Kissei Pharmaceutical Co., Ltd.	Phase 2
Completed	Soothe Versus Refresh NCT00284999	Pharmaceutical Research Network	Phase 4
Completed	Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007) NCT00548301	Sirion Therapeutics, Inc.	Phase 3
Completed	A Study of KCT-0809 in Patients With Dry Eye Syndromes NCT01211951	Kissei Pharmaceutical Co., Ltd.	Phase 2
Completed	A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes NCT01890941	Kissei Pharmaceutical Co., Ltd.	Phase 2
Completed	Phase 2 Study of KLS-0611 in Patients With Dry Eye Syndromes NCT00721656	Kissei Pharmaceutical Co., Ltd.	Phase 2
Completed	Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005) NCT00502073	Sirion Therapeutics, Inc.	Phase 3
Completed	A Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome NCT01427816	Kissei Pharmaceutical Co., Ltd.	Phase 2
Completed	Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-006) NCT00549289	Sirion Therapeutics, Inc.	Phase 3