| Not Yet Recruiting | Virtual Mindfulness and Breathing Training for Stress, Burnout, Sleep, and Cognition in Rotating-Shift Nurses NCT07028788 | Chang Shih-Chin | N/A |
| Not Yet Recruiting | ME/CFS Brain Fog: Cognitive Rehabilitation Trial NCT07523113 | University of Alabama at Birmingham | N/A |
| Recruiting | Brain Stimulation and Cognitive Training for MCI NCT07526740 | Medical University of South Carolina | N/A |
| Recruiting | taVNS + CCT for Neurocognitive Rehab NCT07517237 | Medical University of South Carolina | N/A |
| Recruiting | Stem Cell Therapy for Early Alzheimer's Disease NCT06775964 | Paul E Schulz | Phase 1 / Phase 2 |
| Recruiting | Cognitive Remediation NCT07171450 | Cutter Lindbergh | N/A |
| Not Yet Recruiting | Eye Movement Parameters and Cognitive Functions in Older Adults NCT07358598 | National Sun Yat-sen University | — |
| Recruiting | The Association Between Primary Aldosteronism and Cognitive Dysfunction NCT07304674 | Xinjiang Medical University | — |
| Recruiting | The Liver Cirrhosis Cognitive Decline Scale (LiCCoS) NCT07418008 | University of Malaya | — |
| Not Yet Recruiting | A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease NCT07254234 | Eli Lilly and Company | — |
| Recruiting | Microbiota Mediated Flavonoid Metabolites for Cognitive Health NCT07226674 | University of Ulster | N/A |
| Recruiting | Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Ne NCT07394504 | Foundation University Islamabad | N/A |
| Recruiting | HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer) NCT06930846 | Dartmouth-Hitchcock Medical Center | N/A |
| Active Not Recruiting | The Relationship Between Self-Awareness and Risk of Falls During Walking in Adults NCT07367763 | University of Haifa | — |
| Recruiting | Surviving Daily Life NCT07054723 | Thomas Jefferson University | — |
| Enrolling By Invitation | Preventing Loss of Independence Through Exercise in Community Living Centers NCT06972004 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients NCT07122856 | Centre Hospitalier de Gonesse | — |
| Recruiting | HOBSCOTCH-MS-Efficacy Trial NCT06951919 | Dartmouth-Hitchcock Medical Center | N/A |
| Not Yet Recruiting | Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1) NCT07087951 | Chang Gung Memorial Hospital | N/A |
| Withdrawn | Trifecta Research Study NCT06810765 | Johns Hopkins University | Phase 2 |
| Completed | Cognitive Stimulation in Older Adults With Alzheimer's Disease NCT07041008 | Rsocialform - Geriatria, Lda | N/A |
| Recruiting | Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glu NCT07073781 | Leeds Beckett University | N/A |
| Recruiting | Immersive Virtual Reality in Cognitive Rehabilitation of Patients With Post-Stroke Cognitive Impairment NCT07125170 | University of Chile | N/A |
| Not Yet Recruiting | (Neuro)Cognitive Remediation for Adults With OSIs NCT06813378 | Nova Scotia Health Authority | N/A |
| Recruiting | The Better, Harder, Faster, Stronger Study NCT07220512 | Wake Forest University Health Sciences | — |
| Not Yet Recruiting | Screening for Cognitive Disorders in Multiple Sclerosis NCT07030036 | Centre Hospitalier de Gonesse | — |
| Not Yet Recruiting | MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairm NCT06177028 | St. Joseph's Hospital and Medical Center, Phoenix | Phase 2 |
| Not Yet Recruiting | Minocycline in Neurocognitive Outcomes - Sickle Cell Disease NCT05605366 | University of Cincinnati | Phase 1 |
| Not Yet Recruiting | Stanford-Lucidify EEG Delirium Study NCT06999967 | Stanford University | — |
| Completed | Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Funct NCT07097220 | Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine, | N/A |
| Completed | Brain Fog and Life Quality in Menopause NCT06978218 | Merve Coskun | — |
| Not Yet Recruiting | Association Between Cognitive Impairment and the Presence of Hearing Problems and Precarious Conditions NCT06478888 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits NCT06728774 | Portland VA Medical Center | N/A |
| Recruiting | The Application of an AI-driven Multimodal Predictive Model for Cognitive Impairment in Patients With Type 2 D NCT07128186 | Tongji Hospital | — |
| Recruiting | Broccoli Sprout Extract for Cognitive Function NCT07334366 | Pusan National University Yangsan Hospital | N/A |
| Recruiting | Effect of Virtual Reality-Based Music Therapy on Cognitive and Motor Skills in Subacute Stroke Patients NCT07010536 | Suzan Aydın | N/A |
| Recruiting | Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation NCT06936397 | Beykoz University | N/A |
| Completed | Psychophysiological Effects of Green Exercise in Outdoor Green vs. Indoor Control NCT07379164 | Lincoln University College | N/A |
| Recruiting | Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT) NCT06817239 | Nanfang Hospital, Southern Medical University | N/A |
| Recruiting | Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patient NCT07413562 | Beijing Tiantan Hospital | N/A |
| Recruiting | Nutrition-based Interventions to Prevent Cognitive Decline NCT06853405 | Instituto de Saude Publica da Universidade do Porto | N/A |
| Completed | Ultrasound-Guided Stellate Ganglion Block for Alzheimer's Disease NCT07351773 | Taizhou Second People's Hospital | N/A |
| Recruiting | ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults NCT07392723 | Michal Schnaider Beeri, Ph.D. | Phase 2 |
| Recruiting | Polyphenols and Cognitive Decline NCT06507254 | University of California, Los Angeles | N/A |
| Recruiting | Effectiveness of TeleVR App in Cognitive Decline and MCI Patients NCT06793735 | IRCCS Centro Neurolesi Bonino Pulejo | N/A |
| Enrolling By Invitation | Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations NCT06572332 | Chinese University of Hong Kong | — |
| Completed | Humanity Neurotech Device Clinical Trial in Adults With Long COVID Cognitive Dysfunction NCT06739668 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Reme NCT06733714 | Universidade Federal do Rio de Janeiro | N/A |
| Completed | Supportive Psychotherapy as Adjunct to Risperidone for Cognitive Function and Inflammation in Schizophrenia NCT07477301 | Hasanuddin University | Phase 2 |
| Recruiting | Study on Aging and Cognitive Impairment in China NCT06679296 | First Affiliated Hospital of Wenzhou Medical University | — |
| Completed | Investigation of the Effects of Pilates Training in Patients With Drug-Resistant Epilepsy NCT06754124 | Recep Tayyip Erdogan University Training and Research Hospital | N/A |
| Recruiting | Metacognitive Interpersonal Therapy Across Transdiagnostic Eating Disorders, Including Underweight NCT06693089 | GLORIA FIORAVANTI | N/A |
| Recruiting | Memory Training in Insomnia With Cognitive Impairment NCT06969066 | Xuanwu Hospital, Beijing | N/A |
| Recruiting | PRospective Observation on CErebral microvaScular Structure and Function NCT06579677 | Beijing Tiantan Hospital | — |
| Recruiting | Non-randomized Clinical Trial on Cognitive Stimulation With Virtual Reality in Patients With Mild Cognitive Im NCT06977815 | Badalona Serveis Assistencials | N/A |
| Not Yet Recruiting | Computerized Cognitive Rehabilitation of Patients With Cognitive Deficits Due to the Human Immunodeficiency Vi NCT06603727 | Centre Hospitalier Universitaire Vaudois | N/A |
| Completed | Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhi NCT07242040 | Sinai University | — |
| Recruiting | Effects of Video Games and Ball Tossing on Eye Hand Coordination in Elderly With Mild Cognitive Impairment. NCT07182396 | Foundation University Islamabad | N/A |
| Withdrawn | Epilepsy Self-Management for Spanish Speakers: HOBSCOTCH - ESPANOL NCT06462911 | Dartmouth-Hitchcock Medical Center | N/A |
| Not Yet Recruiting | bWell-D Pilot Randomized Controlled Trial NCT06546917 | University of British Columbia | N/A |
| Recruiting | Sexual Dysfunction in Women With Multiple Sclerosis (MS) NCT07193823 | Ege University | — |
| Recruiting | Effects of Balance Training with and Without Gaze Stability Exercises on Cognitive Function Balance and Dynami NCT06672367 | Foundation University Islamabad | N/A |
| Recruiting | Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study NCT06452264 | Kessler Foundation | N/A |
| Recruiting | Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond NCT04109027 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Global Controlled Trial on Effects of an Online Self-Help Program for of Ambitious Altruists on Their Mental H NCT06442072 | Rethink Wellbeing | N/A |
| Recruiting | Impact of the Digital Multi-domain Cognitive Intervention in High-risk Populations for Dementia NCT06442943 | Fujian Provincial Hospital | N/A |
| Active Not Recruiting | HOBSCOTCH for People With Post Acute COVID-19 Syndrome (PACS) NCT06391489 | Dartmouth-Hitchcock Medical Center | N/A |
| Recruiting | Cognitive Leisure and Preclinical Alzheimer's Disease: Exploring Neural Mechanisms NCT06215274 | Yuanjiao Yan | — |
| Recruiting | Long COVID Brain Fog: Cognitive Rehabilitation Trial NCT06095297 | University of Alabama at Birmingham | N/A |
| Completed | Brain Vascular and Neurocognitive Health NCT06497413 | The University of Texas at Arlington | N/A |
| Recruiting | Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adult NCT05830942 | University of Florida | N/A |
| Not Yet Recruiting | Aerobic Dance During Chemotherapy in Breast Cancer Patients With Cognitive Impairment NCT06234150 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Recruiting | A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI NCT06238492 | Kessler Foundation | N/A |
| Recruiting | Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve NCT06279325 | Universidad de Zaragoza | N/A |
| Unknown | Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH NCT06346015 | Beijing Tiantan Hospital | N/A |
| Not Yet Recruiting | Trajectory of Frailty and Cognitive Dysfunction in Older Adults NCT06276166 | Zheng Li | — |
| Unknown | eHealth Interventions for Breast Cancer Cognitive Impairment NCT06103318 | Institut Català d'Oncologia | N/A |
| Completed | Cognitive Function and Glymphatic System in Children with Epilepsy NCT06143241 | Ege University | N/A |
| Not Yet Recruiting | Improving the Referral of Patients With Suspected Cognitive Impairment and Early Dementia NCT05890313 | Universidade do Porto | N/A |
| Completed | Impact of Sociodemographic, Psychological, and Quality of Life Factors on Dual-Task Performance in Elderly Ira NCT06476561 | Çankırı Karatekin University | — |
| Recruiting | Fatigue and Cognitive Dysfunction After Allogeneic Stemcell Transplantation, Prospective PET Study NCT06363396 | Karolinska Institutet | — |
| Recruiting | Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in P NCT06027632 | Centre Francois Baclesse | N/A |
| Recruiting | High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV NCT05965518 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults. NCT06239922 | University of Macau | — |
| Active Not Recruiting | HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH)-Parkinson's Disease (HOBSCOTCH-Par NCT06260228 | Dartmouth-Hitchcock Medical Center | N/A |
| Active Not Recruiting | HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS) NCT06145737 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 NCT06225115 | Kynexis B.V. | Phase 1 |
| Recruiting | Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain. NCT07365696 | Karolinska University Hospital | — |
| Unknown | Personalised Medicine in the Identification of Preclinical Cognitive Impairment. Development of a Predictive R NCT06114290 | Instituto de Salud Carlos III | — |
| Unknown | Electrophysiological Signatures of Cognitive Disorders Related to Intensive Care Unit (ICU) delirium_ BRAINSTO NCT06089538 | University Hospital, Toulouse | N/A |
| Completed | Development and Evaluation of Virtual Reality Experiences for Cognitive Stimulation at the Sociosanitary Cente NCT06155721 | Badalona Serveis Assistencials | N/A |
| Unknown | Minds Navigating the Diagnosis of Mild Cognitive Impairment NCT05690243 | Tuscaloosa Research & Education Advancement Corporation | N/A |
| Recruiting | Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers NCT05596760 | University of Washington | N/A |
| Completed | FitMi AD Home Therapy for Individuals With MCI or Mild Dementia Due to Alzheimer's Disease NCT05504811 | Flint Rehabilitation Devices, LLC | N/A |
| Completed | Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries NCT06793150 | Kocaeli University | Phase 4 |
| Completed | Urdu Translation and Psychometric Analysis of Lawton IADLS. NCT06059768 | Riphah International University | — |
| Completed | A Pilot Randomized Controlled Trial: CoINTEGRATE NCT05732285 | University of Michigan | N/A |
| Completed | Musical Attention Control and Executive Function Training for Adults With MDD NCT05694156 | Unity Health Toronto | N/A |
| Unknown | Prediction Model of Long-term Cognitive Dysfunction and Delirium After Cardiac Surgery NCT05972057 | RenJi Hospital | — |
| Completed | Intensive Aerobic and Resistance Exercise Program (IAREP) NCT06401733 | National University of Singapore | N/A |
| Unknown | Social Cognition and Language in Patients With Gliomas NCT05764460 | University Medical Center Groningen | — |
| Recruiting | Interventions in Mathematics and Cognitive Skills NCT05201534 | Stanford University | N/A |
| Completed | Sleep Disturbance in MCI: A Study of a Cognitive Behavioural Therapy Digital Intervention NCT05568381 | University of Sydney | N/A |
| Suspended | An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X Syndrome NCT05832255 | Nova Mentis Life Science Corp | Phase 2 |
| Unknown | Determination of the Effect of Puzzle Use in Elderly Patients NCT05796830 | Saglik Bilimleri Universitesi | N/A |
| Active Not Recruiting | Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COV NCT05690503 | New York State Psychiatric Institute | Phase 2 |
| Recruiting | Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project NCT05649800 | University of Leicester | — |
| Completed | Study on the Effectiveness of the MTT24.5 Cognitive Training Program on Cognitive Skills, Brain Volume, and Ac NCT06549517 | Institute for Biomedical Research, CONICET | N/A |
| Completed | Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Su NCT07361068 | Bursa Yuksek Ihtisas Training and Research Hospital | — |
| Completed | Feasibility Study on the Use of Redormin®500 on Day-time Cognition NCT05684523 | Max Zeller Soehne AG | Phase 4 |
| Recruiting | Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND) NCT05565833 | University of Virginia | Phase 2 |
| Unknown | The ACDC Study Assessing Cognitive Deterioration in COVID-19 NCT05855434 | NHS Grampian | — |
| Recruiting | Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Fibromyalgia NCT06948903 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | — |
| Withdrawn | Improving Beta-2 Adrenergic Signaling in Alzheimer's Disease NCT02500784 | Palo Alto Veterans Institute for Research | Phase 2 |
| Withdrawn | Goal Management Training in Individuals With PTSD NCT04457271 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Effects of Electroacupuncture on Cognitive Symptoms in Major Depressive Disorder NCT06239740 | Thammasat University | N/A |
| Completed | The Effect of Hypotensive Anesthesia on Cognitive Functions in Orthognatic Surgery NCT06925711 | Medipol University | — |
| Unknown | Efficacy of a Physical and Respiratory Rehabilitation Program for Patients With Persistent COVID-19 (SARS-CoV- NCT05629884 | Fundacin Biomedica Galicia Sur | N/A |
| Unknown | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence NCT05629793 | Fundacin Biomedica Galicia Sur | N/A |
| Completed | Effects of Intradialytic Cognitive and Physical Exercise Training on Functional Status of Hemodialysis Patient NCT05150444 | University Medical Centre Ljubljana | N/A |
| Unknown | Safety and Dosage of a Computerized Cognitive Training Program for Cognitive Dysfunction After COVID-19 NCT05582603 | Universidad Antonio de Nebrija | Phase 1 / Phase 2 |
| Unknown | Chewing Gum and Cognitive Function NCT05873023 | Inha University Hospital | N/A |
| Recruiting | Engaging Parents in Neuropsychological Rehabilitation for Childhood Cancer Survivors: The ImPACT Program - A P NCT05483166 | Aarhus University Hospital | N/A |
| Recruiting | MOBility Disorders Assessment in Patients With Mild COGnitive Disorders NCT05273125 | University Hospital, Lille | — |
| Completed | Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs NCT05912374 | University of Connecticut | N/A |
| Active Not Recruiting | ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings NCT04852601 | Northwestern University | N/A |
| Completed | A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research NCT05444244 | University of Wisconsin, Madison | N/A |
| Unknown | Effect of Epidural Analgesia on Burst Suppression NCT05688449 | Bezmialem Vakif University | Phase 4 |
| Recruiting | Longitudinal Neurocognitive, Psychosocial and Health-related Quality of Life Assessment in Advanced Cancer Sur NCT05667857 | Universitair Ziekenhuis Brussel | N/A |
| Active Not Recruiting | Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias NCT07224139 | Anne Murray | — |
| Completed | Effect of Individual Cognitive Stimulation on Memory and Executive Function in Older Adults With Alzheimer's D NCT05433493 | Rsocialform - Geriatria, Lda | N/A |
| Unknown | The Analysis of Gene Variants Related to POCD in Elderly Patients NCT05419596 | Istanbul University | — |
| Active Not Recruiting | Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke NCT05162781 | University of Alabama at Birmingham | N/A |
| Completed | A Study to Evaluate the Effects of SAGE-718 in Participants With Parkinson's Disease Cognitive Impairment NCT05318937 | Supernus Pharmaceuticals, Inc. | Phase 2 |
| Unknown | The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects Wit NCT06203015 | Lithuanian University of Health Sciences | — |
| Completed | The Effect of Cognitive Rehabilitation on Epileptic Pateints Under Treatment NCT06643559 | Gulhane Training and Research Hospital | N/A |
| Unknown | MICBT for Non-underweight Adults With Eating Disorders NCT05503745 | Centro Trattamento Integrato: Disturbi Alimentari e Obesita | N/A |
| Recruiting | Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Ribo NCT05245903 | Mclean Hospital | — |
| Completed | Rhythmically Entrained Exercise in Community-Dwelling Older Adults NCT05462977 | University of North Carolina, Greensboro | N/A |
| Completed | Eye Tracking Technology in the Diagnosis of Neurological Patients NCT05536921 | AssisTech Sp. z o.o. | — |
| Unknown | Efficacy of Gamified Cognitive Control Training Using de:)Press on Depression Severity add-on to Treatment as NCT05385614 | University Hospital Tuebingen | N/A |
| Completed | Computer Cognitive Training for Post-acute COVID-19 Syndrome NCT05338749 | Nova Southeastern University | N/A |
| Recruiting | Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls W NCT05445180 | Douglas Mental Health University Institute | N/A |
| Terminated | Speed of Processing (SoP) Training Plus α-tACS NCT05198726 | Portucalense University | N/A |
| Completed | Aerobic Exercise for Cognitive Functioning in Patients With Substance Use Disorder NCT05324085 | St. Olavs Hospital | N/A |
| Unknown | Trauma and Critical Care Exposure Examined With PET (TRAPETS) NCT05245253 | Karolinska University Hospital | — |
| Completed | Long-Covid: Treatment of Cognitive Difficulties NCT05167266 | University of Liege | N/A |
| Completed | Multimodal Investigation of Post COVID-19 in Females NCT05225220 | Casa Colina Hospital and Centers for Healthcare | N/A |
| Completed | Frequency of Cognitive Dysfunction in Patients With Chronic Low Back Pain NCT06278467 | Konya Beyhekim Training and Research Hospital | — |
| Withdrawn | Neurofeedback Effectiveness Trial in PTSD NCT04654130 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement) NCT05209555 | Catharina Ziekenhuis Eindhoven | — |
| Completed | Physical and Cognitive Impairments in People Suffering From Long COVID NCT05216536 | Laval University | — |
| Unknown | Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES NCT05140850 | Dunjin Chen | — |
| Completed | Individual Intervention of Cognitive Stimulation NCT05966207 | Escola Superior de Enfermagem de Coimbra | N/A |
| Recruiting | Redesigning the Surgical Pathway (PROMoTE) NCT05114876 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors NCT05258058 | Allison Magnuson | N/A |
| Unknown | Feasibility and Acceptability of a Virtual 'Coping With Brain Fog' Intervention for Young Adults With Cancer NCT05115422 | University of Manitoba | N/A |
| Recruiting | Tennessee Alzheimer's Project NCT05372172 | Vanderbilt University Medical Center | — |
| Unknown | Emotion and Cognitive Function and Brain Imaging Change in HD Patients NCT05137470 | Beijing Friendship Hospital | — |
| Completed | Effect of Raisins on Cognitive Function in Healthy Older Adults NCT04966455 | University of Salamanca | Phase 3 |
| Recruiting | Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy NCT05014399 | Joseph McCollom | — |
| Withdrawn | Cognitive Function and Health-related Quality of Life After Neuro-intensive Care NCT04881097 | Rigshospitalet, Denmark | — |
| Unknown | Open-label, Post-marketing, Prospective Study to Assess Impact of COVID-19 on Cognitive Function in Patients NCT04950673 | Cognivue, Inc. | — |
| Completed | Detection of Visual-Auditory Reaction Rates in Individuals With Type 2 Diabetes NCT05725889 | Baskent University | — |
| Completed | Improving Cognitive Health in COVID-19 Survivors NCT04843930 | Weill Medical College of Cornell University | Phase 2 |
| Active Not Recruiting | Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia NCT04951700 | University of Texas Southwestern Medical Center | — |
| Recruiting | Precision Medicine in the Depression Treatment NCT05616559 | Rigshospitalet, Denmark | — |
| Completed | Effect of Propfol Versus Sevoflurane on Auditory and Cognitive Function NCT04874545 | Beni-Suef University | Phase 4 |
| Completed | Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS) NCT04766554 | Instituto Nacional de Cardiologia de Laranjeiras | N/A |
| Completed | Post-operative Delirium (POD) in Patients Undergoing Hip Fracture Surgery NCT05105906 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Completed | Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme NCT04693611 | CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas | N/A |
| Completed | Transcranial Direct and Alternating Stimulation of the Prefrontal Cortex for Cognitive Improvement in Schizoph NCT05342727 | The National Brain Mapping Laboratory (NBML) | Phase 1 |
| Completed | Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1 NCT04645134 | Pennington Biomedical Research Center | — |
| Completed | DEEPTIME: Human Adaptation in Time Underground Isolation NCT05603780 | University Hospital, Caen | N/A |
| Recruiting | Intelligent Digital Tools for Screening of Brain Connectivity and Dementia Risk Estimation in People Affected NCT05159661 | Oslo University Hospital | — |
| Completed | Effect of Individual Reminiscence Therapy in the Elderly People With Neurocognitive Disorders NCT04658394 | Rsocialform - Geriatria, Lda | N/A |
| Completed | Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD NCT04600323 | University of Colorado, Denver | EARLY_Phase 1 |
| Recruiting | Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment NCT04558164 | University of California, Los Angeles | N/A |
| Unknown | Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketam NCT04134052 | Universidad de Colima | Phase 3 |
| Completed | EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition NCT04529304 | Oslo University Hospital | N/A |
| Terminated | A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease NCT04619420 | Janssen Research & Development, LLC | Phase 2 |
| Completed | Wellbeing After Stroke (WAterS): Supporting Adjustment and Wellbeing After Stroke NCT04655937 | University of Manchester | Phase 1 |
| Completed | Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction NCT04214496 | University of Chile | — |
| Withdrawn | Zinc and Post-Operative Cognitive Dysfunction NCT04369157 | University of Reading | — |
| Completed | The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectom NCT05652426 | Duzce University | — |
| Completed | Kinesiophobia, Quality of Life, and Cognitive Functions in Fibromyalgia Syndrome NCT04695288 | Bozyaka Training and Research Hospital | — |
| Enrolling By Invitation | Strategies for Proactive Health in People With Kidney Function Decline NCT07245186 | Huashan Hospital | — |
| Unknown | MIND-Matosinhos: Multiple Interventions to Prevent Cognitive Decline NCT05383443 | Instituto de Saude Publica da Universidade do Porto | N/A |
| Completed | A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or NCT04602624 | Supernus Pharmaceuticals, Inc. | Phase 2 |
| Unknown | Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease. NCT04569643 | I.M. Sechenov First Moscow State Medical University | — |
| Completed | Diabetic Retinopathy as a Marker of Cognitive Dysfunction and Depression NCT04610749 | Region of Southern Denmark | — |
| Completed | Modafinil for Wakefulness in the Critical Care Units NCT04751227 | King Faisal Specialist Hospital & Research Center | — |
| Completed | Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms NCT04611620 | Indiana University | — |
| Completed | Retinal and Cognitive Dysfunction in Type 2 Diabetes NCT04281186 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Completed | The Danish Neuropsychological Study of the Adverse Effects of ECT NCT04160286 | University of Copenhagen | — |
| Completed | The MentalPlus® for Assessment and Rehabilitation of Cognitive Function After Remission of the Symptoms of COV NCT04632719 | University of Sao Paulo | N/A |
| Unknown | A Multi-center RCT Study on the Efficacy and Mechanism of Multi-channel tDCS in Rehabilitation of Cognitive Fu NCT04133714 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | Changes of Cognitive Function and Orphanin FQ in Diabetic Patients Under General Anesthesia. NCT04576767 | Second Hospital of Shanxi Medical University | — |
| Completed | Lifestyle Physical Activity and Cognitive Training Interventions NCT04556305 | Rush University Medical Center | N/A |
| Completed | Postoperative Cognitive Dysfunction as Geriatric Syndrome NCT05648890 | Tomas Bata Hospital, Czech Republic | — |
| Unknown | Use of Electrophysiological Markers to Predict Post-operative Cognitive Dysfunction NCT04512989 | Rambam Health Care Campus | — |
| Completed | Validity and Reliability of a Self-evaluation Tool for Cognitive Deficits in the Acute Stage After Stroke NCT04624529 | KU Leuven | — |
| Completed | Evaluation of mediVR-KAGURA Guided Therapy NCT04562662 | Japan Society of Clinical Research | N/A |
| Completed | Eye Movement and Cognitive Dysfunction NCT04236375 | Sun Yat-sen University | — |
| Unknown | Online Cognitive Rehabilitation of Executive Dysfunction in Nonamnestic MCI NCT04503798 | Baycrest | N/A |
| Completed | Associations Between General Movements Assessments and Cognitive Development NCT05217056 | Kahramanmaras Sutcu Imam University | — |
| Completed | A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Parkinson's Disease Mild Cogn NCT04476017 | Supernus Pharmaceuticals, Inc. | Phase 2 |
| Completed | MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients NCT04032626 | St. Joseph's Hospital and Medical Center, Phoenix | Phase 2 |
| Completed | COgnitive Intervention to Restore Attention Using Nature Environment NCT04485507 | Indiana University | N/A |
| Completed | Care at 360º: A Long-term Individual Cognitive Stimulation Program NCT04417751 | CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas | N/A |
| Completed | Tai Chi Chuan as Rehabilitation Program for Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients NCT04416841 | Jing Tao | N/A |
| Recruiting | COMPuter-assisted Self-training to Improve EXecutive Function NCT04229056 | Bispebjerg Hospital | N/A |
| Active Not Recruiting | Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-Life Depression NCT05331599 | University of Illinois at Chicago | — |
| Completed | Augmentation of Depression Treatment by Gamified Network Retraining NCT04400162 | University Hospital Tuebingen | N/A |
| Completed | Effect of Dual Task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment NCT05855785 | Seoul National University Boramae Hospital | N/A |
| Completed | Integrative Therapy for Holistic, Natural Cognition and Lifestyle Rehabilitation NCT04284449 | National University of Natural Medicine | — |
| Recruiting | Cognitive Remediation in Forensic Mental Health Care NCT04610697 | The Royal Ottawa Mental Health Centre | N/A |
| Completed | Neuroimmune Dysfunction in Alcohol Use Disorder NCT04210713 | University of Maryland, Baltimore | Phase 1 |
| Completed | Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery NCT04250935 | Bozok University | — |
| Completed | Effects of Hypothermia on Delayed Neurocognitive Recovery (DNR): an Observational Trial Among Patients Undergo NCT03636074 | University of Padova | — |
| Recruiting | Cognitive Function and Fatigue After Brain Abscess NCT04938362 | University of Oslo | — |
| Unknown | From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesi NCT05755321 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | VR-based Intervention for Cognitive Restoration NCT05653596 | Chungnam National University | N/A |
| Recruiting | Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients NCT04289142 | Sunnybrook Health Sciences Centre | Phase 4 |
| Unknown | Predictors of Parkinson's Disease Progression NCT04062279 | Ain Shams University | — |
| Withdrawn | The Influence of Ventilation on Perioperative Neurocognitive Disorders NCT04106869 | Université Libre de Bruxelles | N/A |
| Completed | Telerehabilitation for Cognitive Impairment Following Acquired Brain Injury NCT03933475 | Hull University Teaching Hospitals NHS Trust | N/A |
| Completed | Change in Cognitive Function in Stimulant Users NCT04061941 | The University of Hong Kong | — |
| Unknown | Association Between qEEG Measure and Post-Operative Cognitive Dysfunction (POCD) and Postoperative Delirium (P NCT03977350 | Neuroindex Ltd. | — |
| Completed | The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease NCT04093882 | Charite University, Berlin, Germany | — |
| Active Not Recruiting | Improving Cognition After Cancer NCT04049695 | University of California, San Diego | N/A |
| Unknown | Multiple Interventions to Prevent Cognitive Decline NCT04079075 | Universidade do Porto | N/A |
| Completed | CAMCI: Advancing the Use of Computerized Screening in Healthcare NCT03512301 | Psychology Software Tools, Inc. | N/A |
| Unknown | Photobiomodulation to Improve Cognition in TBI, With fMRI NCT04230577 | Boston VA Research Institute, Inc. | EARLY_Phase 1 |
| Unknown | Acupressure on Cognitive Function and Quality of Life NCT04441645 | Taipei Medical University | N/A |
| Unknown | XO as a Screening Test of Cognitive Impairment in Multiple Sclerosis NCT03999034 | University Hospital, Clermont-Ferrand | N/A |
| Unknown | Transcutaneous Electrical Stimulation of the Vagus Nerve NCT03989375 | RenJi Hospital | N/A |
| Unknown | Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction NCT03892512 | Beni-Suef University | Phase 1 / Phase 2 |
| Unknown | Nutrition, gUT Microbiota, and BRain AgINg: the NutBrain Study NCT04461951 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Completed | Correlation of NLRP3 With Cognitive Dysfunction Early After Heart Valve Replacement Surgery NCT04191642 | General Hospital of Ningxia Medical University | — |
| Completed | Evaluation of Cognitive Functions by Cerebral Pulse Oximetry NCT03827083 | Tepecik Training and Research Hospital | — |
| Completed | Effects of Partial Sleep Deprivation on Cognitive Function of Anesthesiologists NCT03784560 | Cairo University | — |
| Terminated | A Study of Aducanumab in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease or With Mild A NCT03639987 | Biogen | Phase 2 |
| Terminated | EpxCogScreen -- A Phone-based Rapid Cognitive Screen (RCS) NCT03569722 | Theodore Malmstrom, PhD | — |
| Completed | Renew NCP-5 for the Treatment of Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild Dementia of NCT03721705 | Renew Research, LLC | Phase 3 |
| Unknown | The Influence of Cognitive Decline on Quality of Life After Coronary Bypass NCT03774342 | University Medical Center Groningen | — |
| Unknown | High Dose Omega 3 in People at Risk for Dementia NCT03926351 | University Hospital, Akershus | Phase 2 |
| Unknown | Guilingji Capsule for Mild-to-moderate Cognitive Impairment NCT03647384 | Xiyuan Hospital of China Academy of Chinese Medical Sciences | Phase 2 |
| Unknown | Cognitive Dysfunction in Patients With Cancer Pain NCT03641820 | Fujian Cancer Hospital | — |
| Completed | Effects of Dexmedetomidine on Cognitive Outcome and Brain Injury Markers NCT03585452 | Michał Kowalczyk | N/A |
| Recruiting | PREsurgical Cognitive Evaluation Via Digital clockfacEdrawing NCT03175302 | University of Florida | — |
| Completed | Noninvasive Brain Stimulation for Mild Cognitive Impairment NCT03331796 | Palo Alto Veterans Institute for Research | N/A |
| Withdrawn | Fluoxetine Prevention Trial NCT01615055 | University of California, Los Angeles | EARLY_Phase 1 |
| Completed | Efficacy Study of Yi-Zhi-An-Shen Granules For Older Adults With Amnestic Mild Cognitive Impairment NCT03601000 | Chengdu University of Traditional Chinese Medicine | Phase 1 / Phase 2 |
| Completed | Probing Cortical Excitability and Cognitive Function With TMS NCT03652012 | University of Arizona | N/A |
| Completed | Effect of an Antioxidants Mix on Cognitive Performance and Well Being: The Bacopa, Licopene, Astaxantina, Vita NCT03825042 | A. Menarini Industrie Farmaceutiche Riunite S.r.l. | N/A |
| Completed | The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions NCT03631238 | Assiut University | — |
| Completed | Cerebral Desaturation and Postoperative Dysfunction After Thoracic Surgery NCT03805880 | University of Roma La Sapienza | — |
| Completed | Cognitive and Physical Home-rehabilitation by Information and Communications Technology. Games for Older Adult NCT03383549 | Fondazione Don Carlo Gnocchi Onlus | N/A |
| Completed | Can a New EEG Based Tool Predict Post-operative Delirium and Cognitive Dysfunction? NCT03293550 | Rambam Health Care Campus | — |
| Completed | The Effectiveness of a Cognitive Training Program, Goal Management Training, on Reducing Cognitive Difficultie NCT04076839 | Homewood Research Institute | N/A |
| Completed | Effect of Intraoperative Dexmedetomidine on Early Postoperative Cognitive Dysfunction NCT03793751 | Tata Main Hospital | Phase 4 |
| Completed | BRS and Outcomes in Cardiothoracic Surgery NCT03243279 | Duke University | — |
| Completed | Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy NCT03863925 | Chang Gung Memorial Hospital | Phase 4 |
| Terminated | Evaluation to Assess Cognitive Training for the Prevention of Post-operative Cognitive Decline NCT02747784 | Charite University, Berlin, Germany | N/A |
| Completed | Characteristics and Outcomes of a Capacity-to-Consent Assessment Service NCT03258606 | National Institutes of Health Clinical Center (CC) | — |
| Unknown | Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia NCT03966950 | University of Sao Paulo | N/A |
| Completed | Efficacy and Safety of Cytoflavin® Used in Elderly Patients for the Prevention of Cognitive Decline After Majo NCT03849664 | POLYSAN Scientific & Technological Pharmaceutical Company | Phase 3 |
| Completed | Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil NCT02822573 | Wake Forest University Health Sciences | Phase 3 |
| Unknown | Cerebral Perfusion in the Beach Chair Position NCT03036345 | Brisbane Hand and Upper Limb Research Institute | N/A |
| Unknown | Shanghai Non-pharmacological Intervention of Mild Cognitive Impairment NCT03119051 | Ruijin Hospital | N/A |
| Terminated | Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation NCT03143894 | Johns Hopkins University | N/A |
| Completed | Effects Of An 8-Weeks Mindfulness-based Intervention In Individuals With Subjective Cognitive Decline NCT03005652 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | Near Infrared Spectroscopy for Detection of Cerebral Desaturation After Positioning for Neurosurgical Procedur NCT03093311 | University Hospital Hradec Kralove | N/A |
| Completed | Computerized Virtual Reality in Elderly NCT04984694 | Taipei Medical University | N/A |
| Active Not Recruiting | Risk Factors for Type 2 Diabetes Mellitus With Cognitive Impairment: a Cohort Study NCT05728567 | Peking University | — |
| Recruiting | China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study) NCT06650969 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | — |
| Unknown | Biomarkers in Cerebrospinal Fluid in Critical Care Patients With Delirium NCT02948374 | Sahlgrenska University Hospital | — |
| Unknown | Building the Path to Resilience in Preterm Infants: Mindfulness-based Intervention NCT04638101 | Pediatric Clinical Research Platform | N/A |
| Completed | Three-month Chan-Chung Qigong Improves Physical Function Performance and Quality of Life NCT04904991 | Tri-Service General Hospital | N/A |
| Enrolling By Invitation | Study on Cardiovascular Health, Nutrition and Physical Functioning in Older Adults in Spain NCT03541135 | Universidad Autonoma de Madrid | — |
| Completed | Study of a Daily Cognition Training Program NCT04041999 | University of Salamanca | N/A |
| Completed | Effectiveness of a Psycho-educational Group (PEG) Intervention on Supportive Care and Survivorship Issues in E NCT02600299 | National University of Singapore | Phase 2 |
| Completed | Docosahexaenoic Acid (DHA) To Prevent Development of Cognitive Dysfunction Due to Chemotherapy NCT02517502 | Carol Fabian, MD | EARLY_Phase 1 |
| Completed | Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder NCT02929979 | VA Office of Research and Development | N/A |
| Completed | PRIME: Cognitive Outcome Following Major Burns NCT03242395 | Chelsea and Westminster NHS Foundation Trust | — |
| Unknown | Aprepitant to Mitigate Opioids' Cognitive Side Effects NCT02226601 | University of Arizona | N/A |
| Recruiting | Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major NCT06704451 | First Affiliated Hospital of Kunming Medical University | — |
| Completed | Physical Activity and Neuropsychological Outcomes in a Cancer Population NCT02332876 | University of California, San Diego | N/A |
| Completed | Changes in Cerebral Oxygenation and Cognitive Functions NCT04948957 | Zonguldak Bulent Ecevit University | — |
| Completed | The Difference of Grey Matter Volume Among the Patients of Schizophrenia NCT05262790 | Shanghai Mental Health Center | — |
| Completed | Effect of VSL#3 (Original De Simone Formulation) on Cognitive Function, Risk of Falls and Quality of Life in P NCT01686698 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Phase 4 |
| Completed | Endurance-strength Training in Obese Women NCT04793451 | Poznan University of Medical Sciences | N/A |
| Unknown | Neuropsychological Profile of a Patient's Group With Multiple Sclerosis and Effect of a Cognitive Rehabilitati NCT02193906 | Aveiro University | N/A |
| Completed | Cerebral Oximetry With Near-infrared Spectroscopy and Negative Postoperative Behavioral Changes in Pediatric S NCT02773186 | Hospital Clínico Universitario de Valladolid | — |
| Recruiting | Vanderbilt Memory and Aging Project NCT05372159 | Vanderbilt University Medical Center | — |
| Completed | Combined Transcranial Magnetic Stimulation and Cognitive Treatment in Blast Traumatic Brain Injury NCT01596569 | Boston Medical Center | N/A |
| Completed | Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cogniti NCT01488929 | Targacept Inc. | Phase 2 |
| Active Not Recruiting | BRINK (BRain In Kidney Disease) Memory Study 2.0 NCT04975464 | Anne Murray | — |
| Unknown | The Effect of Physostigmine on Cognitive Functioning in the Immediate Period After Sedation for Colonoscopy NCT01121497 | Rabin Medical Center | N/A |