NCT04093882

The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 101 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

This study attempts to replicate the findings published in Nature Medicine by Nation and colleagues (2019). By using a large observational cohort (DZNE - Longitudinal Cognitive Impairment and Dementia Study; DELCODE) consisting of cognitively healthy individuals, individuals with subjective cognitive decline, mild cognitive impairment, and dementia due to Alzheimer's disease, an association between the blood-brain barrier and cognitive dysfunction is investigated. The integrity of the blood-brain barrier is investigated by using a novel MRI protocol as well as a novel biomarker in the cerebrospinal fluid.

Conditions

• Blood Brain Barrier
• Alzheimer Disease
• Cognitive Dysfunction
• Dementia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Contrast agent enhanced MRI using Gadovist	By using the contrast agent Gadovist we aim to visualize the blood-brain barrier. Furthermore, we aim to measure a newly developed biomarker of the blood-brain barrier in the cerebro-spinal fluid.

Timeline

• Start date: 2019-09-12
• Primary completion: 2021-09-30
• Completion: 2021-09-30
• First posted: 2019-09-18
• Last updated: 2021-11-11

Locations

1 site across 1 country: Germany