NCT05201534

Interventions in Mathematics and Cognitive Skills

Interventions in Math Learning Disabilities: Cognitive and Neural Correlates

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 6 Years – 12 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

Detailed description

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD). To achieve this goal, investigators will use a theoretically-motivated integrated symbolic/non-symbolic (iSNS) intervention with a randomized controlled design to enhance cross-format mapping between symbolic and nonsymbolic representations of quantities. The investigators will develop innovative computational models to investigate individual differences in latent cognitive processes and brain plasticity that contribute to learning, long-term retention, and transfer in children. The investigators will assess performance in several areas and investigate cognitive and neural mechanisms that support numerical skill acquisition in children with differing levels of math learning abilities.

Conditions

• Math Learning Disability
• Child Development
• Developmental Disability
• Learning Disabilities
• Learning Disabled
• Learning Curve
• Mathematics Disorder
• Dyscalculia
• Dyscalculia, Primary
• Dyscalculia, Acquired
• Specific Learning Disorder, With Impairment in Mathematics
• Individuality
• Behavior, Child
• Behavior and Behavior Mechanisms
• Behavior
• Decision Making
• Neuronal Plasticity
• Cognition
• Cognition Disorder
• Cognitive Dysfunction
• Cognitive Change
• Cognitive Impairment, Mild
• Cognitive Developmental Delay
• Cognitive Orientation
• Cognitive Delay, Mild
• Cognitive Deficits, Mild
• Cognitive Abnormality
• Neuroscience

Interventions

Type	Name	Description
OTHER	Interventions in Mathematics and Cognitive Skills - Experimental	After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program.
OTHER	Interventions in Mathematics and Cognitive Skills - Active Comparator	After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program.

Timeline

• Start date: 2023-05-05
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2022-01-21
• Last updated: 2025-08-15

Locations

1 site across 1 country: United States