Trials / Active Not Recruiting
Active Not RecruitingNCT05728567
Risk Factors for Type 2 Diabetes Mellitus With Cognitive Impairment: a Cohort Study
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 3,820 (actual)
- Sponsor
- Peking University · Academic / Other
- Sex
- All
- Age
- 45 Years – 80 Years
- Healthy volunteers
- —
Summary
The aim of this study was to analyze the risk factors for the development of type 2 diabetes mellitus (T2DM) with mild cognitive impairment (MCI) and its pathogenesis associated with gut microbiota. A prospective cohort study was conducted to recruit 3820 participants aged 45 years and above who attended health checkups at the checkup center of Linyi City People's Hospital, Shandong Province. A follow-up survey was conducted identifying whether the participant had T2DM as an exposure factor group. Socio-demographic characteristics, blood, urine, and stool samples, lifestyle surveys, dietary status, and neuropsychological tests were collected at baseline and follow-up, exploring the association between clinical characteristics and gut microbiota and the risk for the development of T2DM with MCI.
Detailed description
The aim of this study was to analyze the risk factors for the development of type 2 diabetes mellitus (T2DM) with mild cognitive impairment (MCI) and its pathogenesis associated with gut microbiota. A prospective cohort study was conducted to recruit 3820 participants aged 45 years and above who attended health checkups at the checkup center of Linyi City People's Hospital, Shandong Province. A follow-up survey was conducted identifying whether the participant had T2DM as an exposure factor group. Socio-demographic characteristics, blood, urine, and stool samples, lifestyle surveys, dietary status, and neuropsychological tests were collected at baseline and follow-up, exploring the association between clinical characteristics and gut microbiota and the risk for the development of T2DM with MCI. Therefore, it is important to explore the factors affecting T2DM with MCI and screen for intervening factors, further elucidate its pathogenesis, and search for specific biological markers of early cognitive impairment in T2DM. This is socially and economically important for screening individuals susceptible to T2DM with MCI so that measures can be taken for early intervention and early treatment to improve the quality of life of patients while reducing medical costs.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | whether the participants had T2DM | whether the participants had T2DM |
Timeline
- Start date
- 2017-01-01
- Primary completion
- 2020-12-31
- Completion
- 2032-01-01
- First posted
- 2023-02-15
- Last updated
- 2023-02-15
Source: ClinicalTrials.gov record NCT05728567. Inclusion in this directory is not an endorsement.