NCT04558164

Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 55 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.

Conditions

• Cognitive Dysfunction
• Memory Disorders in Old Age

Interventions

Type	Name	Description
DEVICE	Active Theta Burst Stimulation	Theta burst transcranial magnetic stimulation (TBS) will be delivered at 80-100% of motor threshold (MT).
DEVICE	Sham Theta Burst Stimulation	Sham stimulation will be delivered at 0-10% of motor threshold (MT), with all other parameters matching the active TBS condition.

Timeline

• Start date: 2021-01-26
• Primary completion: 2026-05-30
• Completion: 2026-06-30
• First posted: 2020-09-22
• Last updated: 2025-03-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study