NCT04645134

Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 25 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 65 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The investigators are conducting a cross-sectional, observational study to investigate whether plasma GPLD1 concentrations are associated with higher cognitive function and better brain structure and function in two groups of older adults with high or low levels of physical activity.

Detailed description

This is a cross-sectional, observational study which will enroll up to 28 healthy, older adults (65-85 y, BMI 20-35 kg/m2), and stratify by current self-reported physical activity level (equal inactive vs. equal highly active). Aim 1: Investigate whether physical activity level is associated with GPLD1. Aim 2: Investigate whether cognitive function and brain structure/function are associated with GPLD1.

Conditions

• Aging
• Cognitive Dysfunction

Interventions

Type	Name	Description
BEHAVIORAL	Brain Health Assessments	The investigators are enrolling up to 28 healthy, older adults (ages 65-85 y, BMI 20-35 kg/m2) stratified by current physical activity level (equal inactive vs. equal highly active). Each physical activity group (inactive and highly active) will undergo a blood draw, body composition, resting metabolic rate, cognitive testing, and magnetic resonance (MR) imaging.

Timeline

• Start date: 2021-04-01
• Primary completion: 2022-03-17
• Completion: 2022-03-17
• First posted: 2020-11-27
• Last updated: 2022-11-16

Locations

1 site across 1 country: United States