NCT05331599

Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-Life Depression

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 210 (estimated)
• Sponsor: University of Illinois at Chicago · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

Late-life depression (LLD) is associated with disability, increased risk for cognitive decline and dementia, elevated suicide risk, and greater all-cause mortality. These outcomes are related to depression being a recurrent disorder, with repeated episodes over a patient's lifetime. Recurrence rates (defined as including both relapse and recurrence) are high in LLD. The goals of this study are to identify neurobiological factors that predict recurrence risk, and examine how cognitive performance changes are both influenced by these neurobiological factors and also predict recurrence risk.

Conditions

• Depression in Old Age
• Recurrence
• Cognitive Dysfunction

Timeline

• Start date: 2020-06-01
• Primary completion: 2025-05-15
• Completion: 2026-01-15
• First posted: 2022-04-15
• Last updated: 2025-09-04

Locations

1 site across 1 country: United States