| Suspended | Safety Profile of Psilocybin for Cocaine Use Disorder NCT06102434 | University of California, Los Angeles | EARLY_Phase 1 |
| Not Yet Recruiting | rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder NCT05974202 | New York State Psychiatric Institute | N/A |
| Not Yet Recruiting | Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disord NCT05529927 | Parnassia Addiction Research Centre | Phase 2 |
| Not Yet Recruiting | LDART for Stimulant Use Disorder NCT07221396 | Yale University | N/A |
| Recruiting | Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder NCT07318480 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder NCT07313371 | University of Sao Paulo General Hospital | Phase 4 |
| Recruiting | Repurposing Semaglutide for the Treatment of Cocaine Use Disorder NCT07227948 | The University of Texas Health Science Center, Houston | Phase 2 |
| Recruiting | Cocaine and Pentoxifylline (BED IN 47) NCT07086794 | William Stoops | EARLY_Phase 1 |
| Not Yet Recruiting | Impact of Cocaine Use and Withdrawal on Sleep NCT07119567 | Hôpital le Vinatier | — |
| Recruiting | Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV NCT06691243 | University of Maryland, Baltimore | Phase 2 |
| Recruiting | CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations NCT06050304 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | A Study to Investigate the Interaction Between TMP-301 and Cocaine. NCT06648668 | Tempero Bio, Inc. | Phase 1 |
| Recruiting | Cocaine Cue-reactivity Incubation Study NCT07091877 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder NCT05986578 | The University of Texas Health Science Center, Houston | N/A |
| Completed | SXC-2023 Cocaine Interaction Study NCT06343532 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Recruiting | Role of Pavlovian Mechanisms for Control Over Substance Use NCT06701487 | Technische Universität Dresden | — |
| Withdrawn | Exenatide For Reducing the Reinforcing Effects of Cocaine NCT06252623 | Christopher D. Verrico | Phase 1 |
| Completed | Phase1, STP7 Cocaine Drug-Drug Interaction Study NCT06273540 | Stalicla SA | Phase 1 |
| Recruiting | Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction NCT06125054 | Dr. med. Marcus Herdener | Phase 2 |
| Recruiting | Treating Polysubstance Use Using a Novel Digital Technology NCT05766631 | Friends Research Institute, Inc. | Phase 3 |
| Recruiting | Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders NCT06434818 | Evon Medics LLC | Phase 2 |
| Active Not Recruiting | Targeting Drug Memories With Methylphenidate NCT05978167 | Icahn School of Medicine at Mount Sinai | EARLY_Phase 1 |
| Completed | Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories NCT05902819 | Psychiatric University Hospital, Zurich | N/A |
| Recruiting | Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder NCT05833529 | Thomas Lehoux | N/A |
| Active Not Recruiting | Contingency Management for Drug Use: Does Age Matter? NCT05521854 | Wake Forest University Health Sciences | N/A |
| Completed | Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2) NCT05262270 | University of Texas Southwestern Medical Center | Phase 2 |
| Unknown | Low-Intensity Focused Ultrasound for Cocaine Use Disorder NCT05857852 | University of Virginia | N/A |
| Completed | Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot NCT05631548 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Multiple Ascending Dose Study of TMP-301 in Healthy Subjects NCT06025396 | Tempero Bio, Inc. | Phase 1 |
| Recruiting | Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine) NCT05610072 | William Stoops | EARLY_Phase 1 |
| Completed | Temporal Window and Episodic Future Thinking in CUD NCT05507814 | Virginia Polytechnic Institute and State University | N/A |
| Completed | Cariprazine for Comorbid Cocaine and Opioid Use Disorder NCT05063201 | Kyle Kampman | Phase 2 |
| Completed | rTMS for Stimulant Use Disorders NCT04907357 | Medical University of South Carolina | N/A |
| Completed | Cocaine and Zolmitriptan NCT05019430 | William Stoops | EARLY_Phase 1 |
| Recruiting | Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives NCT04927143 | Wake Forest University Health Sciences | N/A |
| Completed | Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention NCT04843046 | The University of Texas Health Science Center, Houston | Phase 2 |
| Withdrawn | Study to Assess Safety, Tolerability, and Interactions of Cocaine and Oral AFQ056 NCT04771143 | Novartis Pharmaceuticals | Phase 1 |
| Recruiting | Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study NCT04721418 | Yale University | — |
| Completed | Exenatide for Treating Cocaine Use Disorder NCT04941521 | The University of Texas Health Science Center, Houston | Phase 1 / Phase 2 |
| Unknown | Improvement of Cocaine Use Disorder Treatment Through Cognitive Behavioral Therapy Web-based Treatment (CBT4CB NCT05207228 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Completed | Virtual Reality Exposure and Respiratory Relaxation-Based Coping With Cocaine Craving in Cocaine Users NCT05557149 | Laboratoire de Psychologie des Cognitions | N/A |
| Recruiting | [C-11]NPA PET-amphetamine in Cocaine Use Disorders NCT05011760 | Rajesh Narendran | EARLY_Phase 1 |
| Completed | Neurobehavioral Mechanisms of Cocaine Choice NCT04296006 | Joshua A. Lile, Ph.D. | EARLY_Phase 1 |
| Recruiting | Imaging CRF X NOP Interactions in CUD NCT05008146 | Rajesh Narendran | EARLY_Phase 1 |
| Completed | TDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study NCT04994821 | Soterix Medical | Phase 2 |
| Completed | A Study to Evaluate EMB 001 in Subjects With Cocaine Use Disorder NCT04501874 | Embera NeuroTherapeutics, Inc. | Phase 2 |
| Completed | Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project NCT03799341 | VA Office of Research and Development | N/A |
| Completed | The Effect of Self-Forgiveness on Self-Stigma in Addiction. NCT03971097 | University of Pittsburgh | N/A |
| Completed | Suvorexant and Cocaine NCT03937986 | William Stoops | EARLY_Phase 1 |
| Terminated | Vitamin D and Cocaine Administration NCT04826133 | Yale University | EARLY_Phase 1 |
| Completed | TDCS for Cocaine Addiction Craving NCT03833583 | Soterix Medical | N/A |
| Unknown | Imagery-based Coping for Cocaine Use Disorder NCT03656653 | King's College London | N/A |
| Completed | Feasibility and Validation of a Standard Phenotyping Assessment Battery NCT03495869 | Virginia Commonwealth University | — |
| Completed | Behavioral Effects of Drugs: Inpatient (35) NCT03519022 | Craig Rush | EARLY_Phase 1 |
| Terminated | Cariprazine Effects on Brain and Behavior in Cocaine Use Disorder NCT03430544 | Anna Rose Childress, Ph.D. | Phase 2 |
| Completed | Single Dose Crossover Comparative Bioavailability and Food Effect Study of Two EMB-001 Formulations NCT03404817 | Embera NeuroTherapeutics, Inc. | Phase 1 |
| Completed | Efficacy of Repetitive Transcranial Magnetic Stimulation in Reducing Cocaine Intake in Addicted Patients NCT03607591 | Azienda Ospedaliero-Universitaria Careggi | N/A |
| Terminated | Treatment With Lorcaserin for Cocaine Use: The TLC Study NCT03192995 | Glenn-Milo Santos | Phase 2 |
| Suspended | Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders NCT03344419 | New York State Psychiatric Institute | Phase 3 |
| Completed | Cocaine Use Reduction and Health NCT03224546 | William Stoops | N/A |
| Completed | Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting NCT03662529 | Hunter Holmes Mcguire Veteran Affairs Medical Center | N/A |
| Terminated | Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use NCT02927236 | National Institute on Drug Abuse (NIDA) | N/A |
| Completed | A Study of Metyrapone and Oxazepam Combination Product (EMB-001) and Cocaine NCT02856854 | Embera NeuroTherapeutics, Inc. | Phase 1 |
| Completed | Trial Of NS2359 For The Treatment of Cocaine Dependence NCT02798627 | University of Pennsylvania | Phase 2 |
| Completed | Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use NCT02785406 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | Navigation Services to Avoid Rehospitalization (NavSTAR) NCT02599818 | Friends Research Institute, Inc. | N/A |
| Completed | Methylphenidate-Duloxetine Combinations for Cocaine Dependence NCT02700711 | University of Kentucky | Phase 1 |
| Completed | Reinforcing Effects of Cocaine During Phendimetrazine Maintenance NCT02522325 | William Stoops | Phase 1 |
| Completed | Neural Substrates of Emotion: Impact of Cocaine Dependence NCT02682784 | Medical University of South Carolina | Phase 2 |
| Completed | Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder NCT02537873 | Virginia Commonwealth University | Phase 1 |
| Completed | A Feasibility Trial for Inhibitory-Control Training to Reduce Cocaine Use NCT02444208 | University of Kentucky | N/A |
| Completed | The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy NCT02174614 | Yale University | Phase 1 |
| Completed | Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001) NCT02406066 | Embera NeuroTherapeutics, Inc. | Phase 1 |
| Completed | Predicting Relapse After Cocaine Inpatient Cessation NCT02416050 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Subjective Sleep Quality in CUD TMS-Treated NCT03733821 | Fondazione Novella Fronda | — |
| Completed | [11C]NOP-1A and Cocaine Use Disorders NCT03348384 | University of Pittsburgh | EARLY_Phase 1 |
| Completed | Treatment Outcome in CBT for Cocaine Use NCT03538548 | New York State Psychiatric Institute | N/A |
| Completed | Topiramate-Phentermine Combinations for Cocaine Dependence NCT02239913 | University of Kentucky | Phase 1 |
| Completed | Phendimetrazine and Cocaine NCT02233647 | William Stoops | EARLY_Phase 1 |
| Completed | Extending Long-term Outcomes Through an Adaptive Aftercare Intervention NCT02143063 | UConn Health | N/A |
| Completed | Cocaine Opioid Oxytocin Option - Limited NCT02028533 | University of California, San Francisco | Phase 1 |
| Completed | Occupational Therapy-Based Cognitive Rehabilitation of Cocaine Abusers: A Pilot Study NCT01684293 | University of California, San Francisco | N/A |
| Completed | PPARγ Agonist Treatment for Cocaine Dependence NCT02774343 | The University of Texas Health Science Center, Houston | Phase 1 / Phase 2 |