NCT04721418

Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Detailed description

Healthy controls (HC) will be studied as outpatients and undergo one MRI and one 11C-UCB-J PET scan, along with neurocognitive tasks. Individuals with Cocaine Use Disorder (CUD) will complete the study as inpatients on our unit and undergo one MRI and two 11C-UCB-J PET scans, along with neurocognitive tasks. Participants will complete sleep studies (to evaluate sleep architecture); the first two nights after admission and the last two nights before discharge. Cocaine users will be asked to complete outpatient follow-ups twice a week for up to nine weeks following their inpatient stay.

Conditions

• Cocaine Use Disorder
• Healthy Controls

Interventions

Type	Name	Description
RADIATION	11C-UCB-J	11C-UCB-J PET scan

Timeline

• Start date: 2021-07-20
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2021-01-22
• Last updated: 2025-09-11

Locations

1 site across 1 country: United States