NCT02239913

Topiramate-Phentermine Combinations for Cocaine Dependence

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: University of Kentucky · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will determine the influence of topiramate (Topamax®) and phentermine (Adipex®), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.

Conditions

• Cocaine Use Disorder

Interventions

Type	Name	Description
DRUG	Cocaine	The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and topiramate.
DRUG	Placebo	The pharmacodynamic effects of placebo will be determined during maintenance on placebo and topiramate.
DRUG	Phentermine	The pharmacodynamic effects of phentermine maintenance will be determined during maintenance on placebo and topiramate.
DRUG	Topiramate	The pharmacodynamic effects of chronic topiramate will be determined.

Timeline

• Start date: 2014-09-01
• Primary completion: 2019-09-01
• Completion: 2019-09-01
• First posted: 2014-09-15
• Last updated: 2019-11-27

Locations

1 site across 1 country: United States