| Not Yet Recruiting | Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who NCT07288489 | VarmX B.V. | Phase 3 |
| Recruiting | Prophylactic Intravenous Calcium Gluconate to Decrease Blood Loss at Time of Cesarean Delivery in Pregnant Pat NCT07217899 | University of Michigan | Phase 2 |
| Recruiting | Patient Blood Management in Patients Scheduled for Cardiac Surgery NCT06637137 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score NCT06725732 | Assiut University | EARLY_Phase 1 |
| Not Yet Recruiting | Delivering Transcutaneous Auricular Neurostimulation to Reduce Blood Loss During Dialysis AV Graft Placement P NCT06647017 | University Surgical Vascular | N/A |
| Recruiting | Role of TXA in Patients Undergoing Breast Free Flap Reconstruction NCT06428682 | University of Virginia | Phase 4 |
| Recruiting | B-lynch Transverse Compression Suture NCT06359886 | Alexandria University | N/A |
| Terminated | MisOpRostol Effect on Second Trimester Abortion Blood Loss NCT06078501 | Stanford University | Phase 3 |
| Completed | Dose-Dependent Effects of Intraoperative Tranexamic Acid on Surgical Bleeding and Transfusion Requirements in NCT07288697 | Dr. Lutfi Kirdar Kartal Training and Research Hospital | N/A |
| Completed | Comparative Study Between Preoperative and Postoperative Rectal Misoprostol NCT06049160 | Egymedicalpedia | N/A |
| Completed | Do Anesthesiologists Follow Guidelines on Perioperative Use of Tranexamic Acid? NCT05783648 | Erasme University Hospital | — |
| Unknown | Methods Decreasing Bleeding in Open Myomectomy NCT05806307 | Cairo University | Phase 4 |
| Completed | Efficacy of Carbetocin Versus Oxytocin Plus Misoprostol in Decreasing Blood Loss During Cesarean Section NCT05664659 | Ain Shams Maternity Hospital | Phase 4 |
| Enrolling By Invitation | Reducing Hypotensive Anesthesia Use with TXA During Orthognathic Surgery NCT05474027 | University of Alabama at Birmingham | Phase 4 |
| Withdrawn | Mediastinal Temperature and Post-operative Bleeding NCT04933253 | Virginia Commonwealth University | N/A |
| Unknown | Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy NCT05490147 | Seoul National University Hospital | N/A |
| Active Not Recruiting | Intraoperative Estimated Blood Loss, Blood Transfusion, and Postoperative Clinical Outcomes in Patients Underg NCT05430659 | Siriraj Hospital | — |
| Completed | Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement NCT05391607 | Insel Gruppe AG, University Hospital Bern | Phase 4 |
| Unknown | Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient NCT05427513 | Shaukat Khanum Memorial Cancer Hospital & Research Centre | EARLY_Phase 1 |
| Recruiting | Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in Brazil NCT06601582 | Instituto Materno Infantil Prof. Fernando Figueira | N/A |
| Completed | Comparison Study of Oxytocin Versus Tranexamic Acid and Etamsylaye Versus Placebo(Saline) NCT05273632 | Egymedicalpedia | N/A |
| Terminated | Safe and Timely Antithrombotic Removal - Direct Oral Anticoagulants Apixaban & Rivaroxaban (STAR-D) NCT05093504 | CytoSorbents, Inc | N/A |
| Unknown | Tranexamic Acid During Excisional Burn Surgery NCT05507983 | Maasstad Hospital | Phase 3 |
| Unknown | Effect of Electrosurgery on Blood Loss and Intraoperative Transfusions in Musculoskeletal Tumor Surgery NCT05164809 | University Hospital Muenster | — |
| Recruiting | Safe and Timely Antithrombotic Removal (STAR) Registry NCT05077124 | CytoSorbents, Inc | — |
| Completed | Safe and Timely Antithrombotic Removal - Ticagrelor (STAR-T) NCT04976530 | CytoSorbents, Inc | N/A |
| Unknown | Blood Loss Quantification During Major Abdominal Surgery NCT05316649 | University of Defence, Faculty of Military Health Sciences | — |
| Completed | Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study NCT05522153 | Virtua Health, Inc. | Phase 1 |
| Unknown | Local Subfascial and Intramuscular Tranexamic Acid Administration in Pediatric Patient Undergoing Scoliosis Su NCT04622397 | Cairo University | N/A |
| Completed | Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida NCT04635007 | Cairo University | Phase 3 |
| Unknown | Retransfusion or Not of Cardiotomy Blood NCT04574128 | Örebro University, Sweden | N/A |
| Unknown | ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine Le NCT04519593 | Mother and Child Clinic Saint-Petersburg | N/A |
| Completed | Portal Pressure Effects of Phlebotomy Combined to Vasopressin Use in Cirrhotic Patients Undergoing Liver Trans NCT04472312 | Centre hospitalier de l'Université de Montréal (CHUM) | — |
| Unknown | Suction Drainage in the Management of Peri-operative Bleeding in Total and Unicomcompartmental Knee Arthroplas NCT04508101 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Withdrawn | ROTEM-guided Transfusion Protocol in Attempt to Reduce Blood Transfusions in Major Oncological Surgery NCT03993977 | Tampere University Hospital | N/A |
| Completed | Comparative Study Between Oxytocin Versus Tranexamic Acid and Ethamsylate NCT04656067 | Egymedicalpedia | Phase 1 / Phase 2 |
| Completed | Can Trajectory Nor-epinephrine Infiltration Reduce Blood Loss During Percutaneous Nephrolithotomy (PCNL)? NCT05035303 | Benha University | N/A |
| Completed | Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement NCT04187014 | Carlos A Acosta-Olivo | Phase 2 |
| Completed | Blood Loss Evaluation Using a Novel Device NCT04245995 | Johann Wolfgang Goethe University Hospital | — |
| Completed | Tranexamic Acid for Total Knee Arthroscopy NCT04443920 | The Miriam Hospital | Phase 4 |
| Completed | QStat in Liver Transplant NCT04114253 | HemoSonics LLC | — |
| Completed | Evaluation of the Quantra System in a Surgical Oncological Population NCT04116385 | HemoSonics LLC | — |
| Completed | HemoSonics - UTMB Cardiac Surgery Study NCT03988465 | HemoSonics LLC | — |
| Withdrawn | Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty NCT06638749 | University of Kansas Medical Center | Phase 3 |
| Completed | The Comparison of the Effect of Different Oxytocin Administrations on the Blood Loss During Cesarean Delivery NCT03967171 | Bezmialem Vakif University | N/A |
| Completed | Pre-surgical Evaluation for the Quantra System in Adult Patients Undergoing Cardiac Surgery NCT03931031 | HemoSonics LLC | — |
| Completed | Impact of Hyperoncotic Albumin to Support Blood Loss Replacement NCT03848507 | Insel Gruppe AG, University Hospital Bern | Phase 4 |
| Completed | Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy NCT05108597 | Pak Emirates Military Hospital | Phase 3 |
| Completed | Use of Tranexamic Acid in Liposculpture NCT04430777 | Total Definer Research Group | Phase 2 / Phase 3 |
| Active Not Recruiting | Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections NCT03651154 | Ottawa Hospital Research Institute | N/A |
| Recruiting | Tranexamic Acid in Adult Spinal Deformity Surgery NCT03553186 | Hospital for Special Surgery, New York | Phase 3 |
| Completed | Investigation of the Transfusion Practices in Surgical Patients in Turkey NCT03468738 | Diskapi Teaching and Research Hospital | — |
| Completed | Effects of Intraoperative Blood and Blood Product Consumption on Postoperative Results in Pediatric Cardiac Su NCT03291769 | Cukurova University | — |
| Completed | Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane NCT03379103 | University of Sao Paulo General Hospital | N/A |
| Terminated | Ideal Time of Oxytocin Infusion During Cesarean Section NCT03246919 | Loyola University | Phase 4 |
| Completed | Evaluation of the Clinical Performance of the Quantra System With the Quantra Surgical Cartridge NCT03152461 | HemoSonics LLC | — |
| Completed | Effect of Equal Ratio Ventilation on Blood Loss During Posterior Lumbar Interbody Fusion Surgery NCT03030963 | Gangnam Severance Hospital | N/A |
| Completed | Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery NCT03037515 | Henry Ford Health System | Phase 4 |
| Completed | Non-invasive Perioperative Hb Monitoring in Spinal Surgery NCT02908412 | Tehran University of Medical Sciences | Phase 4 |
| Completed | Estimated Blood Loss: Novel Model for Estimating Surgical Blood Loss. NCT03249038 | Hospital Clinic of Barcelona | — |
| Completed | IV Tranexamic Acid Prior to Hysterectomy NCT02911831 | Northwestern University | EARLY_Phase 1 |
| Unknown | Intravenous vs. Topical Tranexamic Acid in Revision THA (VITALITY-X) NCT02938962 | Mount Sinai Hospital, Canada | Phase 4 |
| Completed | PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding NCT02557672 | Mayo Clinic | Phase 4 |
| Unknown | Effect of High vs. Low MAP Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic Surgery NCT02857153 | Hu Anmin | N/A |
| Unknown | Study to Assess the Effectiveness of Transcollation Technology to Reduce Bleeding in Lung Surgery NCT02631889 | University of Roma La Sapienza | N/A |
| Completed | Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty NCT03044041 | Thammasat University | Phase 4 |
| Completed | Comparison of CABG Related Bleeding Complications in Patients Treated With Ticagrelor or Clopidogrel NCT04431349 | Ajou University School of Medicine | — |
| Completed | Evaluation of Thromboelastometry (ROTEM) During Spinal Surgery NCT02740374 | Ohio State University | N/A |
| Unknown | Intraoperative Volume Management and QT Interval NCT02441751 | Technische Universität Dresden | — |
| Unknown | Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery NCT02438566 | The New England Baptist Hospital | Phase 3 |
| Completed | Prospective, Multicenter, Multidisciplinary, Controlled Clinical Investigation Evaluating the Safety and Effic NCT02359994 | Artivion Inc. | N/A |
| Completed | Tranexamic Acid in Major Vascular Surgery NCT02335359 | IRCCS San Raffaele | Phase 4 |
| Withdrawn | Pilot Study Differential Dissector™ for Blunt Dissection NCT02382952 | University of North Carolina, Chapel Hill | N/A |
| Recruiting | Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury NCT01731444 | University of Manitoba | Phase 1 |
| Unknown | Ultrasonic Scalpel vs. Monopolar Electrocautery for D2 Distal Gastric Carcinoma Surgery NCT02130752 | West China Hospital | N/A |
| Completed | TRANEXAMIC ACID IN PATIENTS UNDERGOING TOTAL HIP ARTHROPLASTY IN A BRAZILIAN REFERENCE ORTHOPEDIC CENTER: A RA NCT03019198 | Instituto Nacional de Traumatologia e Ortopedia | Phase 4 |
| Completed | Tranexamic Acid in Reverse Total Shoulder Arthroplasty NCT02043132 | Corewell Health East | Phase 2 / Phase 3 |
| Unknown | Single Dose of Tranexamic Acid and Blood Loss, in Elderly Patients With Hip Fracture NCT03251469 | National and Kapodistrian University of Athens | Phase 2 |
| Completed | Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial NCT01393704 | Brigham and Women's Hospital | Phase 4 |
| Completed | Observational Study of Prophylaxis and Treatment of Acute Perioperative Bleeding With Beriplex® P/N (Probe Stu NCT01053169 | CSL Behring | — |
| Completed | Safety and Immunogenicity Study of Recombinant Thrombin (rThrombin) in Pediatric Participants NCT00859547 | ZymoGenetics | Phase 4 |
| Completed | Immunogenicity and Safety Study of rThrombin in Surgical Hemostasis NCT00813904 | ZymoGenetics | Phase 4 |
| Withdrawn | Prospective Double-blind Study for the Use of Aspirin During Transurethral Surgery of the Bladder or the Prost NCT00861367 | University Hospital, Basel, Switzerland | N/A |
| Terminated | Tranexamic Acid Versus Placebo to Reduce Perioperative Bleeding After Major Hepatectomy NCT00657384 | University Hospital, Strasbourg, France | Phase 3 |
| Completed | Point of Care Coagulation Testing in Patients Undergoing Major Surgery NCT00656396 | University of Bern | Phase 3 |
| Withdrawn | Haemate HS in Patients With Severe Bleeding Undergoing Valve Replacement Due to Aortic Stenosis NCT00618293 | Heinrich-Heine University, Duesseldorf | Phase 2 |
| Terminated | Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafti NCT00448864 | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 2 |
| Completed | Desmopressin in Cardiac Surgery NCT00337766 | Università Vita-Salute San Raffaele | Phase 4 |
| Terminated | Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Elective Spinal Fusion Surgery NCT00327379 | Bayer | Phase 3 |
| Completed | Evaluation of Fibrin Sealant 2 in Retroperitoneal or Intra-Abdominal Surgery NCT00307515 | Ethicon, Inc. | Phase 3 |
| Terminated | Study to Investigate the Effect of Aprotinin of Transfusion Requirements in Patients Undergoing Surgical Proce NCT00306137 | Bayer | Phase 3 |
| Completed | Observational Cohort Study of TachoSil (TC-018-IN) NCT00285623 | Nycomed | — |
| Terminated | Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectom NCT00306150 | Bayer | Phase 3 |
| Completed | OSHES - Observational Study on Hemostasis in Surgery (TC-022-IT) NCT00279383 | Nycomed | — |
| Completed | Safety Study of Hemospan® in Prostatectomy Patients NCT00425334 | Sangart | Phase 2 |
| Completed | Ergot and Oxytocin During Cesarean Delivery Following Failure to Progress in Labour NCT00481533 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | N/A |
| Completed | Effect of Aprotinin on Transfusion Requirements and Blood Loss in Patients Undergoing Elective Primary Total H NCT00668031 | Bayer | Phase 3 |
| Completed | An Observational Study of Blood Management Techniques in Oncology Surgical Treatment NCT00264095 | Janssen-Cilag B.V. | — |
| Completed | Fresh Frozen Plasma in Cardiac Surgery: Descriptive and Prognostic Study NCT00221741 | University Hospital, Bordeaux | — |