NCT01731444

Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury

Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury - A Randomized Control Trial

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The standard of care for treatment of burn injury is to inject a solution of epinephrine under the skin of the injured site in order to reduce blood loss during skin grafting. This solution of epinephrine has been shown to have effects on the body outside the donor site. Some people have increases in heart rate and blood pressure. We will study the effect of a phenylephrine solution in place of an epinephrine solution to control blood loss. We think that phenylephrine will help decrease blood loss and not change blood pressure or heart rate. The injured area will be injected under the skin and a skin graft will be taken in the same way as we usually do. The only change will be the use of phenylephrine in the solution instead of epinephrine. Our goal is to find whether or not phenylephrine or epinephrine solution results in a reduction of blood loss without affecting the rest of the body.

Conditions

• Blood Loss, Surgical

Interventions

Type	Name	Description
DRUG	Phenylephrine

Timeline

• Start date: 2014-12-01
• Primary completion: 2026-06-01
• Completion: 2027-12-01
• First posted: 2012-11-21
• Last updated: 2024-12-05

Locations

1 site across 1 country: Canada