NCT00657384

Tranexamic Acid Versus Placebo to Reduce Perioperative Bleeding After Major Hepatectomy

Tranexamic Acid Versus Placebo to Reduce Perioperative Bleeding After Major Hepatectomy : a Prospective Randomized Double-blinding Study

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 130 (actual)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Blood loss was reported as a prognostic risk factor of morbidity and overall survival after hepatic resection. The aim of this study prospective randomized was compare the efficacy of the administration of tranexamic acid versus placebo to reduce perioperative bleeding after major hepatectomy (\> 3 hepatic segments).

Conditions

• Blood Loss, Surgical

Interventions

Type	Name	Description
DRUG	acid tranexamic	10 mg/kg Iv after randomization of the patient in the study,follow-up by continuous infusion of 10 mg/kg/h up to the end of the intervention.
DRUG	Nacl 0.9%	10 mg/kg Iv after randomization of the patient in the study,follow-up by continuous infusion of 10 mg/kg/h up to the end of the intervention

Timeline

• Start date: 2008-08-20
• Primary completion: 2013-08-20
• Completion: 2013-11-01
• First posted: 2008-04-14
• Last updated: 2021-03-01

Locations

4 sites across 1 country: France