NCT04933253

Mediastinal Temperature and Post-operative Bleeding

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate how chest temperature relates to blood loss and blood clotting. Researchers will use infra-red thermometers to measure the temperature of the chest at the end of surgery see if this relates to the amount of blood collected from the surgical drains. In addition, researchers will test if warm irrigation of the chest increases the temperature of the chest and if this impacts blood loss.

Detailed description

Low body temperature during surgery, defined as a temperature below 34 °C, occurs commonly in patients undergoing cardiac surgery due to the bypass machine and an open chest. Low body temperature has been associated with blood loss, but the relevant published data are inconclusive. Nevertheless, evidence suggests that blood loss during and after surgery are higher in low body temperature patients than in the normal body temperature patients. In addition, low body temperature can impair blood clotting. The clinical significance of this is high as it is well established that blood transfusion increases mortality after surgery.

Conditions

• Blood Loss, Surgical

Interventions

Type	Name	Description
PROCEDURE	Saline irrigation	Mediastinal irrigation with 2 L of 37 degree Celsius saline prior to chest closure

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-08-01
• Completion: 2025-08-01
• First posted: 2021-06-21
• Last updated: 2022-10-28

Locations

1 site across 1 country: United States