NCT03246919

Ideal Time of Oxytocin Infusion During Cesarean Section

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Loyola University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate if the timing of oxytocin administration in cesarean deliveries will affect the amount of maternal blood loss. Half of participants will receive oxytocin after delivery of the fetal anterior shoulder and the other half will receive oxytocin after delivery of the placenta. We hypothesize that administering oxytocin after delivery of the shoulder, will result in less overall maternal blood loss.

Detailed description

Oxytocin is a routinely administered medication for both vaginal and cesarean deliveries in the third stage of labor, as part of standard of care in the United States. This medication helps to reduce overall blood loss, by functioning as a uterotonic. Currently evidence is lacking to direct timing of oxytocin administration in cesarean deliveries. This study will evaluate both estimated and quantitative blood loss for both groups of patients. It will also compare the change from pre-operative to post-operative hemoglobin levels.

Conditions

• Blood Loss, Surgical
• Postpartum Hemorrhage
• Bleed Pregnancy
• Pregnancy Related
• Cesarean Section Complications

Interventions

Type	Name	Description
DRUG	Oxytocin	Oxytocin is administered after delivery of the fetal anterior shoulder, rather than being administered after delivery of the placenta
DRUG	Placebo	Placebo will be administered after delivery of the placenta

Timeline

• Start date: 2017-09-13
• Primary completion: 2020-02-24
• Completion: 2020-02-24
• First posted: 2017-08-11
• Last updated: 2020-06-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study