| Withdrawn | Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome NCT04725110 | University of Minnesota | Phase 2 |
| Withdrawn | AllogeneiC Expanded Human MSC Therapy in Patients Recovering From COVID-19 Acute Respiratory Distress Trial NCT05491681 | BioCardia, Inc. | Phase 1 |
| Not Yet Recruiting | Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Ret NCT06444750 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Withdrawn | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for ARDS NCT05127122 | Direct Biologics, LLC | Phase 1 / Phase 2 |
| Recruiting | Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot NCT05847634 | University of Manitoba | — |
| Recruiting | Digital Early Warning System for Acute Lung Injury in Liver Surgery NCT07070362 | Beijing Tsinghua Chang Gung Hospital | — |
| Recruiting | Non-invasive Phrenic Nerve Stimulation in ARDS Patient NCT06572280 | Southeast University, China | N/A |
| Not Yet Recruiting | Echocardiographic Evaluation of RV Injury in the ICU NCT05525936 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study. NCT06119516 | Assistance Publique - Hôpitaux de Paris | N/A |
| Not Yet Recruiting | Renal Doppler to Predict Acute Kidney Injury (AKI) in ARDS Patients. (RED-AKI Study) NCT06302192 | Policlinico Hospital | — |
| Completed | Exhaled Nitric Oxide : Biomarker of Acute Respiratory Distress Syndrome NCT06250348 | University Hospital, Grenoble | — |
| Recruiting | Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury NCT06321497 | Peninsula Health | — |
| Recruiting | Regional Assessment of the Risk of Lung Injury in Ventilated Patients NCT06486259 | Hospital El Cruce | — |
| Enrolling By Invitation | Potential Biomarkers and Pathogenic Mechanism for Reflux Aspiration-induced Lung Injury. NCT06164639 | Shanghai Zhongshan Hospital | — |
| Recruiting | Pulmonary Immune Cell-microbiome Interactions in ARDS NCT05795257 | Hvidovre University Hospital | — |
| Completed | Effect of Electric Impedance Tomography-Guided PEEP Titration NCT05736185 | Southeast University, China | N/A |
| Unknown | Effect of Chest Compression on Respiratory Mechanics in ARDS Patients NCT05598476 | Central Hospital, Nancy, France | — |
| Terminated | Efficacy and Safety Evaluation of BZ371B in ARDS Patients NCT05384379 | Biozeus Biopharmaceutical S.A. | EARLY_Phase 1 |
| Unknown | Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation NCT05306392 | Central Hospital, Nancy, France | N/A |
| Recruiting | Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome NCT05492344 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Completed | First-In-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALT-100 NCT05426746 | Aqualung Therapeutics Corp. | Phase 1 |
| Completed | PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial NCT05307913 | Peking Union Medical College Hospital | N/A |
| Completed | Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration Accor NCT05337059 | University Hospital, Angers | N/A |
| Completed | Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS NCT05442073 | Peking Union Medical College Hospital | — |
| Unknown | Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS NCT05524558 | Bicetre Hospital | — |
| Unknown | The Diagnosis of Superinfections in Mechanically Ventilated Covid-19 Patients NCT05148975 | Brno University Hospital | — |
| Unknown | Characterization of the microVAScular Dysfunction in Covid-19 ARDS NCT05074758 | Assistance Publique - Hôpitaux de Paris | — |
| Withdrawn | LIght Sedation Pressure Support NCT03783468 | University Hospital, Lille | N/A |
| Unknown | MRG-001 as an Immunoregulatory and Regenerative Therapy for COVID-19 Patients NCT04646603 | MedRegen LLC | Phase 2 |
| Recruiting | Regional Citrate Anticoagulation for RRT During V-V ECMO NCT05148026 | University of Milano Bicocca | N/A |
| Unknown | The Mechanism of Extracellular Vesicles Containing Mitochondrial DNA in ARDS Lung Injury Caused by Extrapulmon NCT05061212 | Southeast University, China | — |
| Completed | Factors Associated With Decisions to Withhold or Withdraw Intensive Care NCT05394961 | Uppsala University | — |
| Completed | Universal Anti-Viral Vaccine for Healthy Elderly Adults NCT04441047 | Mirror Biologics, Inc. | Phase 1 / Phase 2 |
| Completed | Assessing the Role of Inclined Positioning in Acute Respiratory Distress Syndrome Patients Recovery NCT04612608 | Peter Morris | N/A |
| Completed | Therapeutic Plasma Exchange to Alleviate Hyperinflammatory Condition During Severe Covid-19 Infections NCT04751643 | Hospices Civils de Lyon | N/A |
| Active Not Recruiting | Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning NCT04744298 | University of Calgary | N/A |
| Completed | Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator NCT04729075 | Northwell Health | — |
| Unknown | Management of Cytokine Storms in Severe COVID-19 Patients With Autologous Activated Platelet-rich Plasma Thera NCT04715360 | Hayandra Peduli Foundation | Phase 1 / Phase 2 |
| Completed | Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury NCT04511923 | University College Hospital Galway | Phase 1 / Phase 2 |
| Completed | London's Exogenous Surfactant Study for COVID19 NCT04375735 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 1 / Phase 2 |
| Completed | Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS NCT06224010 | University of Turin, Italy | — |
| Unknown | Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS NCT04530188 | Bicetre Hospital | Phase 3 |
| Unknown | Hemodynamic Impact on Critical Care Patients With Lung Damage Secondary to COVID-19 NCT04556864 | Juan Victor Lorente | — |
| Completed | Use of Prone Position Ventilation in Danish Patients With COVID-19 Induced Severe ARDS Treated With VV-ECMO NCT05693051 | Rigshospitalet, Denmark | — |
| Completed | Practice of Adjunctive Treatments in Intensive Care Unit Patients With COVID-19 NCT04719182 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Terminated | Pilot Study of Single Dose Bevacizumab as Treatment for Acute Respiratory Distress Syndrome (ARDS) in COVID-19 NCT04954014 | Maimónides Biomedical Research Institute of Córdoba | Phase 2 |
| Completed | Advisory Lead ARDS Respirator Management NCT04274296 | Mathias Maleczek | — |
| Withdrawn | Early Versus Late ECMO Therapy in COVID-19 Induced ARDS (ECMO-VID) NCT04341285 | University Hospital Tuebingen | N/A |
| Unknown | Regenerative Medicine for COVID-19 and Flu-Elicited ARDS Using Lomecel-B (RECOVER) NCT04629105 | Longeveron Inc. | Phase 1 |
| Terminated | Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE NCT04347941 | University College Hospital Galway | N/A |
| Unknown | MSC-based Therapy in COVID-19-associated Acute Respiratory Distress Syndrome NCT04525378 | D'Or Institute for Research and Education | Phase 1 |
| Completed | Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS NCT04359290 | Philipps University Marburg | Phase 2 |
| Unknown | Respiratory Mechanics and Gas Exchange Characteristics in Patient With SARS-CoV-2 NCT04486729 | Sanatorio Anchorena San Martin | — |
| Unknown | PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort NCT04444609 | Imperial College London | — |
| Active Not Recruiting | Mesenchymal Stromal Cell Therapy For The Treatment Of Acute Respiratory Distress Syndrome NCT04447833 | Uppsala University | Phase 1 |
| Terminated | Glycine Supplement for Severe COVID-19 NCT04443673 | Instituto Nacional de Enfermedades Respiratorias | N/A |
| Completed | External Dead Space in Ventilated COVID-19 Patients NCT04424082 | Karolinska Institutet | N/A |
| Unknown | Capnography Monitoring in Ventilated Children NCT04354220 | Vincenzo Cannizzaro | — |
| Terminated | Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 NCT04327505 | Karolinska Institutet | Phase 2 / Phase 3 |
| Completed | Using GM-CSF as a Host Directed Therapeutic Against COVID-19 NCT04400929 | Singapore General Hospital | Phase 2 |
| Unknown | Electrical Impedance Tomography Monitoring and Invasive Mechanical Ventilation During Pronation in Acute Respi NCT04605133 | Azienda Sanitaria-Universitaria Integrata di Udine | — |
| Terminated | Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury NCT04397510 | Frederick Health | Phase 4 |
| Unknown | Curosurf® in Adult Acute Respiratory Distress Syndrome Due to COVID-19 NCT04384731 | Dr Christophe LENCLUD | Phase 2 |
| Unknown | Prone Positioning Short-term Effects on Tissue Oxygen Saturation in Critical COVID-19 Patients NCT04692129 | Corporacion Parc Tauli | — |
| Completed | Inhaled Iloprost for Suspected COVID-19 Respiratory Failure NCT04445246 | Hamad Medical Corporation | Phase 2 |
| Unknown | Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19) NCT04397497 | Ospedale San Raffaele | Phase 2 |
| Terminated | Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms NCT04382391 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Completed | Cardiac Dysfunction in Critically Ill Covid-19 Patients NCT06197256 | Region Stockholm | — |
| Unknown | Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS NCT04503057 | Lund University Hospital | — |
| Completed | Use of UC-MSCs for COVID-19 Patients NCT04355728 | Camillo Ricordi | Phase 1 / Phase 2 |
| Unknown | Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency NCT04594668 | University of Aarhus | Phase 2 |
| Unknown | The Critical Care Response to the COVID-19 Pandemic in Madrid NCT04393324 | Hospital San Carlos, Madrid | — |
| Completed | Sevoflurane in COVID-19 ARDS (SevCov) NCT04355962 | University of Zurich | Phase 3 |
| Completed | WeanINg From Mechanical Ventilation for ARDS CovId-19 Patients Guided by Combined Thoracic UltraSound. NCT04372680 | University Hospital, Toulouse | N/A |
| Withdrawn | The Use of Tadalafil in Confirmed COVID-19 Pneumonia. NCT04946162 | Santa Barbara Cottage Hospital | Phase 4 |
| Unknown | Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19 NCT04456361 | Instituto de Medicina Regenerativa | EARLY_Phase 1 |
| Terminated | Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection NCT04356443 | Massachusetts General Hospital | — |
| Unknown | European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO NCT04366921 | Maastricht University Medical Center | — |
| Active Not Recruiting | Treatment of ARDS With Instilled T3 NCT04115514 | University of Minnesota | Phase 2 |
| Completed | Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome NCT04323592 | University of Trieste | — |
| Unknown | Evaluation of Von Willebrand Factor as a Marker For Early Diagnosis of Acute Respiratory Distress Syndrome (A. NCT04317469 | Ain Shams University | — |
| Withdrawn | Echocardiography in Patients With Covid-19 NCT04412460 | University Hospital Tuebingen | — |
| Completed | Adverse Events Related to Treatments Used Against Coronavirus Disease 2019 NCT04314817 | Groupe Hospitalier Pitie-Salpetriere | — |
| Completed | EIT in Patient Ventilator Asynchrony NCT04442815 | National Cheng-Kung University Hospital | — |
| Unknown | Smartphone Application for Initiation of Protective Ventilation. Clinical Impact of Instrumental Dead Space Re NCT04390360 | Laval University | N/A |
| Unknown | Optimal PEEP Titration Combining Transpulmonary Pressure Measurement and Electric Impedance Tomography NCT04174014 | Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged | N/A |
| Completed | Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning (TheraPPP) Pathway NCT04070053 | University of Calgary | N/A |
| Terminated | Decrease of Lesions Induced by Mechanical Ventilation During ARDS NCT03918603 | Assistance Publique Hopitaux De Marseille | N/A |
| Unknown | A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamic NCT04020003 | Shenzhen Second People's Hospital | Phase 3 |
| Terminated | Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients NCT03202641 | Massachusetts General Hospital | N/A |
| Unknown | Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis NCT03854565 | Southeast University, China | — |
| Unknown | ECCO2R - Mechanical Power Study NCT03939260 | University of Milan | — |
| Recruiting | Alveolar Macrophage Programming Following Endotoxin Exposure NCT03859050 | National Jewish Health | N/A |
| Unknown | Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist NCT03868982 | Fu Jen Catholic University | N/A |
| Unknown | Predictors of Intracranial Hemorrhage in ARDS Patients on ECMO NCT04142775 | Charite University, Berlin, Germany | — |
| Unknown | Clinical Study of Titrating PEEP of Different Methods on Right Heart Function NCT03845556 | Southeast University, China | — |
| Completed | Hemoglobin Concentration in Patients With an Acute Respiratory Distress Syndrome NCT03871166 | Charite University, Berlin, Germany | — |
| Terminated | Enhanced Lung Protective Ventilation With ECCO2R During ARDS NCT03525691 | Hôpital Européen Marseille | N/A |
| Completed | Application of Indicator Based-electrical Impedance Tomography Method Assess Lung Regional Perfusion in ICU Pa NCT04081142 | Yun Long | — |
| Completed | The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome NCT04542538 | Uppsala University | — |
| Completed | Driving Pressure and Mortality: in the Pediatric Intensive Care Unit (PICU) NCT04419376 | Dr. Behcet Uz Children's Hospital | — |
| Completed | Effect of Lung Protective One-lung Ventilation With Fix and Variable PEEP on Oxygenation and Outcome NCT03968120 | University of Debrecen | N/A |
| Recruiting | Fulminant Severe CAP - an Observational Study NCT06516601 | University of Trieste | — |
| Unknown | Hemodynamic Effects of PEEP in ARDS NCT03896802 | University of Milan | N/A |
| Completed | The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium NCT03337373 | Mahidol University | Phase 4 |
| Completed | Prone Position Impact in ARDS Patients on the Incidence of Central Venous Catheter Colonization NCT03405038 | Centre Hospitalier Régional Metz-Thionville | — |
| Completed | Screening Expiratory Flow Limitation by Flow-time Curve NCT03215316 | Unity Health Toronto | — |
| Withdrawn | Hemodynamic Effects of Changes in Transpulmonary Pressure During Recruitment Maneuver in Patients Under Pressu NCT04141293 | Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged | N/A |
| Completed | Cytokine Hemoadsorption in ECMO Patients NCT04901338 | University Medical Centre Ljubljana | — |
| Completed | Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume NCT03364465 | University of Debrecen | N/A |
| Completed | The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality NCT04508296 | Northern State Medical University | N/A |
| Completed | Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuc NCT04008225 | Rennes University Hospital | — |
| Completed | Functional Respiratory Imaging of Airways in ARDS NCT03309085 | University Hospital, Antwerp | N/A |
| Completed | Predictive Factors, Demographics and Mortality for ARDS in Burn Patients NCT03807232 | University of Zurich | — |
| Unknown | Steroids in Patients With Early ARDS NCT00562835 | Catholic University of the Sacred Heart | Phase 2 / Phase 3 |
| Completed | Prone-Supine Study II: The Effect of Prone Positioning for Patients Affected by Acute Respiratory Distress Syn NCT00159939 | Policlinico Hospital | Phase 3 |
| No Longer Available | Compassionate Use Open-Label Anti-CD14 Treatment in Patients With SARS-CoV-2 (COVID-19) NCT04346277 | Implicit Bioscience | — |