NCT03854565

Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

Predictive Value of Glycocalyx Biomarkers in Mechanical Ventilation of Patients With ARDS for Clinical Prognosis and Long-term Pulmonary Fibrosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 336 (estimated)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury. Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Conditions

• ARDS, Human
• Endothelial Dysfunction
• Mechanical Ventilation Pressure High

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Glycocalyx measurement，respiratory mechanics measurement	ELASA measure glycocalyx, measure plateau pressure, driving pressure

Timeline

• Start date: 2019-05-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2019-02-26
• Last updated: 2019-02-26

Locations

1 site across 1 country: China