NCT06250348

Exhaled Nitric Oxide : Biomarker of Acute Respiratory Distress Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to see if endogenous exhaled Nitric Oxyde (eNO) concentrations measured are significantly higher in ARDS patients admitted in ICU ; compared to control subjects in good health with no lung disease or global inflammation, operated under general anesthesia (i.e. intubated and ventilated) for thyroid or parathyroid.

Detailed description

The measurement of endogenous exhaled NO is monitored using a laser spectrometer machine connected to the expiratory circuit of the respirator. The measure is non-invasive and made by sampling expiratory gaz like for capnography. In control subjects, the measurement period corresponds to the first ten minutes after induction of anesthesia (with intubation) before surgical incision. In ARDS patients in intensive care, the measurement of eNO is made in the first twenty-four hours after intubation and ventilation of the patient with mechanical respirator. The primary endpoint is a significantly higher eNO concentration in patients suffering from Acute Respiratory Distress Syndrome (ARDS). Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria: PaO2/FiO2; ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days.

Conditions

• ARDS, Human
• Nitric Oxyde

Interventions

Type	Name	Description
OTHER	Non invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer	A sample of exhaled gases is taken from the expiratory part of the respirator circuit (same way as a capnometry measurement). A laser spectrometer continuously and non-invasively monitors online the concentrations of endogenous NO exhaled by patients.

Timeline

• Start date: 2024-02-15
• Primary completion: 2024-09-01
• Completion: 2025-01-05
• First posted: 2024-02-09
• Last updated: 2025-03-30

Locations

1 site across 1 country: France