NCT05442073

Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

Effect of Initial Empirical Positive End-Expiratory Pressure (PEEP) Setting on the Esophageal Pressure-guided PEEP Titration in Acute Respiratory Distress Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

Conditions

• ARDS, Human
• PEEP, Occult
• Esophageal and Pleural Pressure

Interventions

Type	Name	Description
OTHER	PEEP adjustment	adjusting PEEP about 3-5cmH2O (increase or decrease)

Timeline

• Start date: 2022-03-01
• Primary completion: 2022-05-31
• Completion: 2022-06-29
• First posted: 2022-07-01
• Last updated: 2022-07-01

Locations

1 site across 1 country: China